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1.14.19.47: acyl-lipid (9-3)-desaturase

This is an abbreviated version!
For detailed information about acyl-lipid (9-3)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.47

Reaction

a linoleoyl-[glycerolipid]
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a gamma-linolenoyl-[glycerolipid]
+
ferricytochrome b5
+ 2 H2O

Synonyms

acyl-lipid 6-desaturase, AL1, D-6 desaturase, D6D, D6Des, DELTA 6-desaturase, DELTA-6 desaturase, DELTA-6-desaturase, DELTA6 desaturase, DELTA6-desaturase, DELTA6-fatty acid desaturase, DELTA6fad, DES6, FADS2, fadsd6, fatty acyl DELTA6 desaturase, PyDes6

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.47 acyl-lipid (9-3)-desaturase

Cloned

Cloned on EC 1.14.19.47 - acyl-lipid (9-3)-desaturase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Anabaena sp.
-
expressed in Arabidopsis thaliana
expressed in Aspergillus oryzae
expressed in HEK-293 cells
-
expressed in Nicotiana tabacum leaf and Arabidopsis thaliana seed
expressed in Pichia pastoris
-
expressed in Saccharomyces cerevisiae
expressed in Saccharomyces cerevisiae DBY746 cells
expressed in Saccharomyces cerevisiae strain W303-1A and Arabidopsis thaliana
expressed in Solanum lycopersicum
heterologous expression in yeast
heterologous expression of native and codon-optimized PyDes6 cDNAs in Saccharomyces cerevisiae
investigation of the effects of these proteins on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhance polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity