1.14.19.41: sterol 22-desaturase

This is an abbreviated version!
For detailed information about sterol 22-desaturase, go to the full flat file.

Word Map on EC 1.14.19.41

1.14.19.41

ergosterol

stigmasterol

azole

desaturases

ketoconazole

phytosterols

campesterol

beta-sitosterol

withanolides

withania

somnifera

xanthophyllomyces

dendrorhous

brassicasterol

14alpha-demethylase

sitosterol

Reaction

+ 2 H2O

Synonyms

C-22 sterol desaturase, CTP61, CYP61, CYP710A, CYP710A1, CYP710A11, CYP710A13, CYP710A14, CYP710A2, CYP710A4, cytochrome P-450 sterol DELTA22-desaturase, cytochrome P-45061, cytochrome P45061, DELTA22-desaturase, ERG5, Erg5p, P450 61, Sd1, sterol 22-desaturase, sterol C-22 desaturase, sterol C22 desaturase, sterol C22-desaturase, sterol DELTA22-desaturase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.19.41 sterol 22-desaturase

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Results	in table
16	AA Sequence
3	Cloned(Commentary)
15	Cofactor
1	Expression
6	General Information
6	IC50 Value
24	Inhibitors
2	kcat/KM [mM/s]
1	Ki Value [mM]
8	KM Value [mM]
10	Localization
8	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
31	Organism
5	Pathway
1	Protein Variants
3	Purification (Commentary)
1	Reaction
27	Reference
2	Source Tissue
29	Substrates and Products (Substrate)
11	Subunits
50	Synonyms
1	Systematic Name
5	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.14.19.41 - sterol 22-desaturase

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22,23-dihydrobrassicasterol + NADPH + H+ + O2

brassicasterol + NADP+ + H2O

Saccharomyces cerevisiae

highest activity

733242

24-epi-campesterol + NADPH + H+ + O2

brassicasterol + crinosterol + NADP+ + H2O

Arabidopsis thaliana

O64697, O64698

substrate for isoform CYP710A2 but not CYP710A1

733311

brassicasterol is the major product

24-epi-campesterol + NADPH + H+ + O2

brassicasterol + NADP+ + H2O

Arabidopsis thaliana

734886

24-methylcholesterol + NADPH + H+ + O2

brassicasterol + NADP+ + H2O

Arabidopsis thaliana

O64697, Q9ZV28

734989

beta-sitosterol + NADPH + H+ + O2

stigmasta-5,22-dien-3beta-ol + NADP+ + H2O

Solanum lycopersicum

734014

beta-sitosterol + NADPH + H+ + O2

stigmasterol + NADP+ + H2O

5 entries

clionasterol + NADPH + H+ + O2

poriferasterol + NADP+ + H2O

Saccharomyces cerevisiae

733242

ergosta-5,7,24(28)-trien-3beta-ol + NADPH + H+ + O2

ergosta-5,7,22,24(28)-tetraen-3-beta-ol + NADP+ + 2 H2O

Saccharomyces cerevisiae

744282

ergosta-5,7,24(28)-trien-3beta-ol + NADPH + H+ + O2

ergosta-5,7,22,24(28)-tetraen-3-beta-ol + NADP+ + H2O

2 entries

ergosta-5,7-dien-3beta-ol + NADPH + H+ + O2

ergosterol + NADP+ + H2O

5 entries

ergosta-5,7-dienol + NADPH + H+ + O2

ergosterol + NADP+ + H2O

3 entries

sitosterol + NADPH + H+ + O2

stigmasterol + NADP+ + H2O

Saccharomyces cerevisiae

733242

additional information

6 entries