Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.19.4: acyl-lipid (11-3)-desaturase

This is an abbreviated version!
For detailed information about acyl-lipid (11-3)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.4

Reaction

an (11Z,14Z)-icosa-11,14-dienoyl-[glycerolipid]
+ 2 ferrocytochrome b5 +
O2
 + 2 H+ =
an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid]
 + 2 ferricytochrome b5 + 2 H2O

Synonyms

AtSLD1, AtSLD2, Boofd8, Ca-SLDp, D8A, DELTA6-desaturase, DELTA8 acyl-CoA-dependent desaturase, DELTA8 desaturase, DELTA8 sphingobase desaturase, Delta8 sphingolipid desaturase, DELTA8-desaturase, DELTA8-fatty-acid desaturase, DELTA8-sphingolipid desaturase, FADS2, SLD, SlSLD, sphingolipid delta8 desaturase, sphingolipid DELTA8 LCB desaturase, sphingolipid DELTA8 long-chain base desaturase, sphingolipid DELTA8-desaturase, TpdesB

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.4 acyl-lipid (11-3)-desaturase

Substrates Products

Substrates Products on EC 1.14.19.4 - acyl-lipid (11-3)-desaturase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S,3R)-2-aminoicosane-1,3-diol + reduced acceptor + O2
(E)-(2S,3R)-2-aminoicos-8-ene-1,3-diol + (Z)-(2S,3R)-2-aminoicos-8-ene-1,3-diol + acceptor + H2O
show the reaction diagram
-
-
-
-
?
(E)-sphing-4-enine + reduced acceptor + O2
(2S,3R,4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol + acceptor + H2O
show the reaction diagram
(R)-9-fluorophytosphinganine + reduced acceptor + O2
(Z)-9-fluoro-8-phytosphingenine + acceptor + H2O
show the reaction diagram
-
exclusively produces (Z)-9-fluoro-8-phytosphingenine. This result is explained by an initial attack onto the C8-HR and syn-elimination of two vicinal hydrogen atoms via an anti-conformation of the substrate. An initial attack on the C9-F is excluded and generates no product
-
-
?
(S)-8-fluorophytosphinganine + reduced acceptor + O2
(Z)-8-fluoro-8-phytosphingenine + acceptor + H2O
show the reaction diagram
-
product predominantly transformed to (Z)-8-fluoro-8-phytosphingenine along with only trace amounts of the (E)-8-fluoro-8-phytosphingenine (ratio 95:5). This ratio indicates that the fluorinated substrate strongly favors the anti-configuration at the active center of the desaturase
-
-
?
(S)-9-fluorophytosphinganine + reduced acceptor + O2
(E)-9-fluoro-8-phytosphingenine + acceptor + H2O
show the reaction diagram
-
produces (E)-9-fluoro-8-phytosphingenine as the sole reaction product. Only the initial attack on the C9-HR in combination with the gauche-conformation of the substrate is productive
-
-
?
11,14,17-eicosatrienoic acid + reduced acceptor + O2
8,11,14,17-eicosatetraenoic acid + acceptor + H2O
show the reaction diagram
-
-
-
?
11,14,17-eicosatrienoic acid + reduced acceptor + O2
?
show the reaction diagram
20:3n-3, yield 20:4n-3
-
-
?
11,14-eicosadienoic acid + reduced acceptor + O2
8,11,14-eicosatrienoic acid + acceptor + H2O
show the reaction diagram
-
-
-
?
11,14-eicosadienoic acid + reduced acceptor + O2
?
show the reaction diagram
20:2n-6, yield 20:3n-6
-
-
?
11-eicosenoic acid + reduced acceptor + O2
8,11-eicosadienoic acid + acceptor + H2O
show the reaction diagram
-
-
-
?
4-hydroxysphinganine + reduced acceptor + H2O
4-hydroxy-trans-8-sphingenine + acceptor + H2O
show the reaction diagram
DELTA4-sphingenine + reduced acceptor + O2
DELTA4,8-sphingadienine + acceptor + 2 H2O
show the reaction diagram
-
production of two water molecules in the reaction
-
?
phytosphinganine + reduced acceptor + O2
(8E)-4-hydroxy-8-sphingenine + (8Z)-4-hydroxy-8-sphingenine + acceptor + H2O
show the reaction diagram
-
reaction in a in a stereospecific manner by syn elimination of two vicinal hydrogen atoms
production of two water molecules in the reaction
-
?
phytosphinganine + reduced acceptor + O2
DELTA8-phytosphingenine + acceptor + H2O
show the reaction diagram
-
production of two water molecules in the reaction
-
?
phytosphinganine + reduced acceptor + O2
trans-8-sphingenine + cis-8-sphingenine + acceptor + H2O
show the reaction diagram
sphinganine + reduced acceptor + O2
DELTA8-sphingenine + acceptor + 2 H2O
show the reaction diagram
-
production of two water molecules in the reaction
-
?
additional information
?
-