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1.14.19.33: DELTA12 acyl-lipid conjugase (11E,13E-forming)

This is an abbreviated version!
For detailed information about DELTA12 acyl-lipid conjugase (11E,13E-forming), go to the full flat file.

Reaction

a gamma-linolenoyl-[glycerolipid]
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
an alpha-parinaroyl-[glycerolipid]
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

DELTA12 desaturase, DELTA12 oleate desaturase, FADX, FADX-1A, FADX-1B, FADX-2, fatty acid DELTA12-conjugase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.33 DELTA12 acyl-lipid conjugase (11E,13E-forming)

General Information

General Information on EC 1.14.19.33 - DELTA12 acyl-lipid conjugase (11E,13E-forming)

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
tung FADX is grouped with DELTA12 fatty acid desaturases and hydroxylases rather than conjugases, which is consistent with its desaturase activity
physiological function
FADX converts linoleic acid into alpha-eleostearic acid. in the plant seed oil
additional information
incubation of yeast cells expressing FADX with exogenously supplied palmitoleicacid leads to substantial incorporation of thisfatty acid into yeast cells, accounting for approximately79% of total fatty acids. Oleic acid is reduced to only 3% under these growth conditions