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1.14.19.30: acyl-lipid (8-3)-desaturase

This is an abbreviated version!
For detailed information about acyl-lipid (8-3)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.30

Reaction

an (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid]
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid]
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

acyl-lipid 5-desaturase, AL21, C20 DELTA5cis-desaturase, D5b, D5D, D5des, delta 5 desaturase, DELTA 5 fatty acid desaturase, delta-5 desaturase, DELTA-5-desaturase, DELTA5 desaturase, DELTA5 fatty acid desaturase, DELTA5-Des, DELTA5-desaturase, DELTA5-fatty acid desaturase, DELTA5-fatty-acid desaturase, DES5, desat7, FadA, FadB, FADS1, fads2b, FAT-4, fatty acid desaturase, PPDES5, PsD5Des

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.30 acyl-lipid (8-3)-desaturase

IC50 Value

IC50 Value on EC 1.14.19.30 - acyl-lipid (8-3)-desaturase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000034
2-amino-5-chloro-N-(3-chlorophenyl)benzamide
Mus musculus
-
pH and temperature not specified in the publication
0.000067
2-amino-N-(3-chlorophenyl)-5-fluorobenzamide
Mus musculus
-
pH and temperature not specified in the publication
0.000058
2-amino-N-(3-chlorophenyl)benzamide
Mus musculus
-
pH and temperature not specified in the publication
0.000516
2-amino-N-(3-fluorophenyl)benzamide
Mus musculus
-
pH and temperature not specified in the publication
0.000843
2-amino-N-[3-(propan-2-yl)phenyl]benzamide
Mus musculus
-
pH and temperature not specified in the publication
0.000021
5-bromo-N-(3-chlorophenyl)-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000005
5-chloro-N-(3-chlorophenyl)-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000084
N-(3-chlorophenyl)-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000173
N-(3-chlorophenyl)-2,3-dihydro-1H-inden-1-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000015
N-(3-chlorophenyl)-2-hydroxy-5-methoxybenzamide
Mus musculus
-
pH and temperature not specified in the publication
0.000174
N-(3-chlorophenyl)-2-hydroxybenzamide
Mus musculus
-
pH and temperature not specified in the publication
0.003
N-(3-chlorophenyl)-5-(trifluoromethoxy)-1H-indazol-3-amine
Mus musculus
-
IC50 above 0.003 mM, pH and temperature not specified in the publication
0.000254
N-(3-chlorophenyl)-5-(trifluoromethyl)-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000925
N-(3-chlorophenyl)-5-ethoxy-2-hydroxybenzamide
Mus musculus
-
pH and temperature not specified in the publication
0.000058
N-(3-chlorophenyl)-5-fluoro-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000008
N-(3-chlorophenyl)-5-methoxy-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000006
N-(3-chlorophenyl)-5-methyl-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000371
N-(3-chlorophenyl)furo[3,2-c]pyridin-4-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000017
N-(3-chlorophenyl)naphthalen-1-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000011
N-(3-chlorophenyl)quinazolin-4-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000018
N-(3-chlorophenyl)quinolin-4-amine
Mus musculus
-
pH and temperature not specified in the publication
0.00026
N-(3-chlorophenyl)thieno[2,3-d]pyrimidin-4-amine
Mus musculus
-
pH and temperature not specified in the publication
0.00005
N-(3-chlorophenyl)thieno[3,2-d]pyrimidin-4-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000059
N-(3-fluorophenyl)-1H-indazol-3-amine
Mus musculus
-
pH and temperature not specified in the publication
0.000058
sesamin
Mus musculus
-
pH and temperature not specified in the publication