1.14.19.30: acyl-lipid (8-3)-desaturase
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For detailed information about acyl-lipid (8-3)-desaturase, go to the full flat file.
Word Map on EC 1.14.19.30
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1.14.19.30
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arachidonic
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polyunsaturated
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linoleic
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desaturation
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phospholipid
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desaturases
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pufas
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delta-6
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docosahexaenoic
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eicosapentaenoic
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dihomo-gamma-linolenic
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delta6-desaturase
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elongase
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monounsaturated
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alpha-linolenic
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gamma-linolenic
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stearoyl-coa
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mortierella
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omega-6
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alpina
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8-hydroxyoctanoic
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lc-pufas
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sesamin
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eicosatrienoic
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medicine
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agriculture
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diagnostics
- 1.14.19.30
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arachidonic
-
polyunsaturated
-
linoleic
-
desaturation
- phospholipid
-
desaturases
-
pufas
-
delta-6
-
docosahexaenoic
-
eicosapentaenoic
-
dihomo-gamma-linolenic
- delta6-desaturase
- elongase
-
monounsaturated
-
alpha-linolenic
-
gamma-linolenic
- stearoyl-coa
-
mortierella
-
omega-6
- alpina
-
8-hydroxyoctanoic
-
lc-pufas
- sesamin
-
eicosatrienoic
- medicine
- agriculture
- diagnostics
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 + 2 H2O
Synonyms
acyl-lipid 5-desaturase, AL21, C20 DELTA5cis-desaturase, D5b, D5D, D5des, delta 5 desaturase, DELTA 5 fatty acid desaturase, delta-5 desaturase, DELTA-5-desaturase, DELTA5 desaturase, DELTA5 fatty acid desaturase, DELTA5-Des, DELTA5-desaturase, DELTA5-fatty acid desaturase, DELTA5-fatty-acid desaturase, DES5, desat7, FadA, FadB, FADS1, fads2b, FAT-4, fatty acid desaturase, PPDES5, PsD5Des
ECTree
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General Information
General Information on EC 1.14.19.30 - acyl-lipid (8-3)-desaturase
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malfunction
metabolism
physiological function
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the lower dienoic acid content of the fadA mutant results in a tolerance of elevated temperatures during development, but not during the growth phase
malfunction
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the lower dienoic acid content of the fadA mutant results in a tolerance of elevated temperatures during development, but not during the growth phase
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delta 5 desaturase plays a role in the eicosapentaenoic acid biosynthetic pathway
metabolism
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the DELTA5-desaturase is involved in the last step of arachidonic acid (20:4n-6) biosynthesis from dihomo-gamma-linolenic acid (20:3n-6), contributing to the balance between the prostanoids of the 1- and 2-series
metabolism
the C-peptide (a protein cleaved from pro-insulin) may function in regulating DELTA-5 desaturase enzyme activity. Relationship between body mass index, C-peptide, and DELTA-5-desaturase enzyme activity estimates in adult males
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isoforms FadA and FadB are involved in temperature adaptation. Isoform FadA is mainly responsible for the production of dienoic fatty acids, whereas isoform FadB has a supplementary function
physiological function
Fads1 is an effector of LXR agonist-driven transcriptional control of fatty acid and cholesterol metabolic programs in the liver. Fads1 reciprocally regulates hepatic inflammation and lipogenesis. Fads1 knockdown promotes Dyslipidemia and Atherosclerosis in a diet-specific manner
physiological function
investigation of the effects of DELTA-5 and DELTA-6 desaturase on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhances polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity
physiological function
involved in moth pheromone biosynthesis
physiological function
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isoforms FadA and FadB are involved in temperature adaptation. Isoform FadA is mainly responsible for the production of dienoic fatty acids, whereas isoform FadB has a supplementary function
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