1.14.19.3: acyl-CoA 6-desaturase
This is an abbreviated version!
For detailed information about acyl-CoA 6-desaturase, go to the full flat file.
Word Map on EC 1.14.19.3
-
1.14.19.3
-
polyunsaturated
-
arachidonic
-
desaturation
-
pufas
-
phospholipid
-
docosahexaenoic
-
eicosapentaenoic
-
gamma-linolenic
-
unsaturated
-
cholesterol
-
alpha-linolenic
-
elongase
-
triglyceride
-
la
-
lc-pufas
-
palmitic
-
elovl5
-
adipose
-
delta-5
-
monounsaturated
-
triacylglycerols
-
stearoyl-coa
-
linolenic
-
prostaglandin
-
phosphatidylcholine
-
dihomo-gamma-linolenic
-
eicosanoids
-
omega-6
-
delta5-desaturase
-
5-desaturase
-
linseed
-
borage
-
evening
-
stearic
-
primrose
-
teleost
-
palmitoleic
-
stearidonic
-
eczema
-
mortierella
-
seabream
-
alpina
-
srebf1
-
eicosatrienoic
-
synthesis
-
nutrition
-
safflower
-
desaturase-1
-
gilthead
-
aurata
-
flaxseed
-
stearoyl
-
diagnostics
-
drug development
- 1.14.19.3
-
polyunsaturated
-
arachidonic
-
desaturation
-
pufas
- phospholipid
-
docosahexaenoic
-
eicosapentaenoic
-
gamma-linolenic
- unsaturated
- cholesterol
-
alpha-linolenic
- elongase
- triglyceride
- la
-
lc-pufas
-
palmitic
- elovl5
- adipose
-
delta-5
-
monounsaturated
- triacylglycerols
- stearoyl-coa
-
linolenic
- prostaglandin
- phosphatidylcholine
-
dihomo-gamma-linolenic
-
eicosanoids
-
omega-6
- delta5-desaturase
-
5-desaturase
-
linseed
-
borage
-
evening
-
stearic
- primrose
-
teleost
-
palmitoleic
-
stearidonic
- eczema
- mortierella
- seabream
- alpina
-
srebf1
-
eicosatrienoic
- synthesis
- nutrition
- safflower
-
desaturase-1
-
gilthead
- aurata
-
flaxseed
-
stearoyl
- diagnostics
- drug development
Reaction
Synonyms
acyl-CoA DELTA6-desaturase, acyl-CoA desaturase, acyl-CoA-dependent DELTA6-desaturase, AsD6DES, D6 desaturase, d6-des, D6D, D6Des, DEALTA6I, delta 6 desaturase, DELTA 6-desaturase, delta 6-fatty acid desaturase, DELTA-6 desaturase, delta-6 fatty acid desaturase, DELTA-6-desaturase, DELTA6 desaturase, DELTA6 fatty acid desaturase, DELTA6 fatty acyl desaturase, DELTA6-acyl CoA desaturase, DELTA6-acyl-group desaturase, DELTA6-desaturase, DELTA6-desaturase II, DELTA6-fatty acid desaturase, DELTA6-fatty acyl-CoA desaturase, delta61, DELTA6fad_b, DES6, desaturase, fatty acid DA6-, desaturase, linoleate, DesI, EaD6DES, EC 1.14.99.25, FA desaturase 2, FADS2, FADS6, fadsd6, FAT-3, fatty acid 6-desaturase, fatty acid DA6-desaturase, fatty acid DELTA 6-desaturase, fatty acid delta-6 desaturase, fatty acid DELTA6-desaturase, fatty acid desaturase 2, fatty acid desaturase-2, GcFADS2, linoleate desaturase, linoleic acid desaturase, linoleic desaturase, linoleoyl CoA desaturase, linoleoyl-coenzyme A desaturase, long-chain fatty acid DELTA6-desaturase, MaFADS6, MaFADS6-I, Md6, MpFADS6, PiDesD6, TpFADS2
ECTree
1.14.19.3 acyl-CoA 6-desaturaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.14.19.3 - acyl-CoA 6-desaturase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid + AH2 + O2
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoic acid + A + H2O
-
-
-
-
?
alpha-linolenic acid + AH2 + O2
(6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraenoic acid + A + 2 H2O
preferred substrate
-
-
?
alpha-linolenic acid + AH2 + O2
octadeca-6,9,12,15-tetraenoic acid + A + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
gamma-linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
39% conversion efficiency
-
-
?
gamma-linolenic acid + AH2 + O2
cis-6,9,12,15-octadecatetraenoic acid + A + H2O
-
-
-
-
?
heptadec-9-enoic acid + AH2 + O2
heptadec-6,9-dienoic acid + A + H2O
-
conversion rate is 17%
-
-
?
linoleoyl phosphatidylcholine + AH2 + O2
gamma-linolenoylphosphatidylcholine + A + H2O
-
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
octadec-9,12-dienoic acid + AH2 + O2
octadec-6,9,12-trienoic acid + A + H2O
-
conversion rate is 11.5%
-
-
?
octadec-9-enoic acid + AH2 + O2
octadec-6,9-dienoic acid + A + H2O
-
conversion rate is 19.1%
-
-
?
palmitoyl-[acyl-carrier protein] + reduced acceptor + O2
6-hexadecenoyl-[acyl-carrier protein] + acceptor + H2O
-
-
-
?
stearoyl-[acyl-carrier protein] + reduced acceptor + O2
6-octadecenoyl-[acyl-carrier protein] + 9-octadecenoyl-[acyl-carrier protein]acceptor + H2O
-
-
ratio of activity: 2/1
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
conversion rate: 7.0
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
conversion rate: 31.5
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
-
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
-
conversion rate: 59.5
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
alpha-linolenic acid + AH2 + O2
octadec-6,9,12,15-tetraenoic acid + A + 2 H2O
conversion rate: 23.1
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
-
-
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
-
conversion rate is 19%
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
conversion rates of 45.9%
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
conversion rates of 45.9%
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
-
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
-
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
-
-
-
?
alpha-linolenic acid + AH2 + O2
stearidonic acid + A + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
?
alpha-linolenoyl-CoA + ferrocytochrome b5 + O2 + H+
stearidonoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
alpha-linoleoyl-CoA + AH2 + O2
stearidonoyl-CoA + A + 2 H2O
-
-
-
-
?
gamma-linolenic acid methyl ester + O2
?
-
7% conversion efficiency
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
conversion rate: 1.5
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
key enzyme localized in the endoplasmic reticulum
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
DELTA6-desaturase reaction is the rate-limiting step in the conversion of linoleic acid and alpha linoleic acids to the longer, more highly unsaturated members of the n-6 and n-3 polyunsaturated fatty acids, metabolic pathway in mammalian cells
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
conversion rates of 14.2%
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
conversion rates of 14.2%
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
DELTA6-desaturase reaction is the rate-limiting step in the conversion of linoleic acid and alpha linoleic acids to the longer, more highly unsaturated members of the n-6 and n-3 polyunsaturated fatty acids, metabolic pathway in mammalian cells
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
conversion rate: 3.6
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
important for the generation of unsaturated fatty acids, DELTA6-desaturase required for the conversion of dietary linoleic acid to arachidonic acid
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
DELTA6-desaturase reaction is the rate-limiting step in the conversion of linoleic acid and alpha linoleic acids to the longer, more highly unsaturated members of the n-6 and n-3 polyunsaturated fatty acids, metabolic pathway in mammalian cells
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
14.4% conversion rate
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
conversion rate: 31.2
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
the enzyme is responsible for the first and rate-limiting step in biosynthesis of highly unsaturated fatty acids
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
conversion rate: 12.2
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
preferred substrate
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
preferred substrate
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
preferred substrate
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
linoleoyl-CoA + ferrocytochrome b5 + O2 + H+
gamma-linolenoyl-CoA + ferricytochrome b5 + H2O
-
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
-
-
-
?
octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
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octadeca-9,12-dienoic acid + AH2 + O2
gamma-linolenic acid + A + H2O
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palmitate + AH2 + O2
sapienate + A + H2O
the enzyme is a component of the lipid metabolic pathway that converts the essential fatty acids linoleate and alpha-linolenate into long-chain polyunsaturated fatty acids. The DELTA-6 desaturase/FADS2 expressed in human sebocytes catalyzes the conversion of palmitate into sapienate
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palmitic acid + AH2 + O2
hexadec-6-enoic acid + A + H2O
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key enzyme required for numerous vital functions involving distinct polyunsaturated fatty acids and polyunsaturated fatty acid-derived bioactive lipids. It seems that the biological importance of DELTA6-desaturase activity should also be considered for its newly identified role in the control of the biosynthesis of a monoenoic fatty acid (C16:1 n-10), particularly in tissues with low DELTA9-desaturase activity
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additional information
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low activity with C15:1DELTA9 fatty acid and C16:1DELTA9 fatty acid
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additional information
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the zebrafish enzyme is a bifunctional DELTA5/DELTA6 desaturase
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additional information
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the enzyme is essential for the formation of long-chain metabolites from dietary linoleic acid and alpha-linolenic acid, but shows a slow activity in humans. A defect in the activity of DELTA6 and DELTA5 desaturases decreases the formation of gamma-linolenic acid, dihomo-gamma-linoleic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid from dietary linoleic acid, and alpha-linolenic acid. This, in turn, leads to inadequate formation of prostaglandins E1 and I3, prostacyclin, lipoxins resolvins, neuroprotectin D1, NO, and nitrolipids that have anti-inflammatory and platelet anti-aggregatory actions, inhibit leukocyte activation, augment wound healing, and resolve inflammation and thus, leads to the initiation and progression of atheroslcerosis, metabolism of essential fatty acids, overview, enzyme activity is decreased in diabetes mellitus, hypertension, hyperlipidemia, and metabolic syndrome X
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additional information
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alpha-linoleic acid is converted to eicosapentaenoic acid by the enzyme, the enzyme is also active with linoleic, which is converted to gamma-linoleic acid, and oleic acid
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additional information
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D6D activity in preterm, term, and post-natals is estimated by the 20:3n-6/18:2n-6 ratio
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additional information
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PiDes6 desaturates both omegax6 and omega3 substrates, substrate specificity in comparison to other fatty acid desaturases, overview
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additional information
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delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
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additional information
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delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
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additional information
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the enzyme MpFADS6 shows a substrate preference for alpha-linolenoyl-CoA, sequences between the histidine boxes I and II plays a pivotal role in substrate preference, mutational analysis, substrate specificities of wild-type and mutant enzymes, overview. MpFADS6 has a preference for the alpha-linolenoyl-CoA substrate with a 66.5% conversion rate
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additional information
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the enzyme MpFADS6 shows a substrate preference for alpha-linolenoyl-CoA, sequences between the histidine boxes I and II plays a pivotal role in substrate preference, mutational analysis, substrate specificities of wild-type and mutant enzymes, overview. MpFADS6 has a preference for the alpha-linolenoyl-CoA substrate with a 66.5% conversion rate
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additional information
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delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
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additional information
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the enzyme MpFADS6 shows a substrate preference for alpha-linolenoyl-CoA, sequences between the histidine boxes I and II plays a pivotal role in substrate preference, mutational analysis, substrate specificities of wild-type and mutant enzymes, overview. MpFADS6 has a preference for the alpha-linolenoyl-CoA substrate with a 66.5% conversion rate
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additional information
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delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
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additional information
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delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
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additional information
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polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
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additional information
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polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
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additional information
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the enzyme MaFADS6-I shows a substrate preference for linoleoyl-CoA, sequences between the histidine boxes I and II plays a pivotal role in substrate preference, mutational analysis, substrate specificities of wild-type and mutant enzymes, overview. When a single substrate is added, linoleoyl-CoA and alpha-linolenoyl-CoA are catalyzed by MaFADS6 with conversion rates of 45.6% and 19.6%, respectively. When linoleoyl-CoA and alpha-linolenoyl-CoA are added at the same time, the linoleoyl-CoA conversion rate reaches 58.4%, but alpha-linolenoyl-CoA conversion decreases to 2.0%
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additional information
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the enzyme MaFADS6-I shows a substrate preference for linoleoyl-CoA, sequences between the histidine boxes I and II plays a pivotal role in substrate preference, mutational analysis, substrate specificities of wild-type and mutant enzymes, overview. When a single substrate is added, linoleoyl-CoA and alpha-linolenoyl-CoA are catalyzed by MaFADS6 with conversion rates of 45.6% and 19.6%, respectively. When linoleoyl-CoA and alpha-linolenoyl-CoA are added at the same time, the linoleoyl-CoA conversion rate reaches 58.4%, but alpha-linolenoyl-CoA conversion decreases to 2.0%
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additional information
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delta 6 desaturase (FADS6) is a key bifunctional enzyme desaturating linoleic acid or alpha-linolenic acid, analysis of the molecular mechanism of substrate specificity, overview
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additional information
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the enzyme MaFADS6-I shows a substrate preference for linoleoyl-CoA, sequences between the histidine boxes I and II plays a pivotal role in substrate preference, mutational analysis, substrate specificities of wild-type and mutant enzymes, overview. When a single substrate is added, linoleoyl-CoA and alpha-linolenoyl-CoA are catalyzed by MaFADS6 with conversion rates of 45.6% and 19.6%, respectively. When linoleoyl-CoA and alpha-linolenoyl-CoA are added at the same time, the linoleoyl-CoA conversion rate reaches 58.4%, but alpha-linolenoyl-CoA conversion decreases to 2.0%
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additional information
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polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
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additional information
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polyunsaturated fatty acid profiles in Mortierella alpina, the lipids are synthesized mainly via the omega6 pathway and rarely via the omega3 pathway and as a result contain low alpha-linolenoyl-CoA and eicosapentaenoic acid levels
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additional information
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the FADS2 product introduces a double bond at the DELTA6, DELTA4 and DELTA8 positions by acting on at least ten substrates, including fatty acids 16:0, 18:2n-6, and 18:3n-3. MCF7 cells stably transformed with FADS2 biosynthesizes fatty acid 16:1n-10 from exogenous fatty acid 16:0, fatty acid 18:4n-3 from fatty acid 18:3n-3, fatty acid 18:3n-6 from fatty acid 18:2n-6, fatty acid 18:2n-9 from fatty acid 18:1n-9, fatty acid 24:6n-3 from fatty acid 24:5n-3 and fatty acid 24:5n-6 from fatty acid 24:4n-6
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additional information
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fatty acid DELTA6-desaturation is the first commited step in C20 polyunsaturated fatty acid biosynthesis
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additional information
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fatty acid DELTA6-desaturation is the first commited step in C20 polyunsaturated fatty acid biosynthesis
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with by DELTA6fad_b
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with by DELTA6fad_b
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with by DELTA6fad_b
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with by DELTA6fad_b
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with DELTA6fad_c
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with DELTA6fad_c
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with DELTA6fad_c
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additional information
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no activity with 20:4n-3, 20:3n-6, 22:5n-3, and 22:4n-6 with DELTA6fad_c
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