1.14.19.29: sphingolipid 8-(E/Z)-desaturase
This is an abbreviated version!
For detailed information about sphingolipid 8-(E/Z)-desaturase, go to the full flat file.
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 + 2 H2O
Synonyms
8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8 Des, Delta8 sphingolipid desaturase, DELTA8(E,Z)-sphingolipid desaturase, Delta8-fatty-acid desaturase 1, Delta8-fatty-acid desaturase 2, DELTA8-sphingolipid desaturase, Delta8-sphingolipid desaturase 1, Delta8-sphingolipid desaturase 2, Delta8-sphingolipid desaturase 3, DELTA8-sphingolipid-desaturase, DES8, DXDES, LCB DELTA8 desaturase, PtD8A, PtD8B, PtD8C, SLD, SLD1, SLD2, sphingoid long-chain base DELTA8 desaturase, sphingolipid DELTA8-desaturase
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Reference
Reference on EC 1.14.19.29 - sphingolipid 8-(E/Z)-desaturase
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Sperling, P.; Libisch, B.; Zahringer, U.; Napier, J.A.; Heinz, E.
Functional identification of a DELTA8-sphingolipid desaturase from Borago officinalis
Arch. Biochem. Biophys.
388
293-298
2001
Borago officinalis, Borago officinalis (Q9FR82)
Libisch, B.; Michaelson, L.V.; Lewis, M.J.; Shewry, P.R.; Napier, J.A.
Chimeras of DELTA6-fatty acid and DELTA8-sphingolipid desaturases
Biochem. Biophys. Res. Commun.
279
779-785
2000
Borago officinalis (Q9FR82)
Sperling, P.; Blume, A.; Zahringer, U.; Heinz, E.
Further characterization of DELTA8-sphingolipid desaturases from higher plants
Biochem. Soc. Trans.
28
638-641
2000
Arabidopsis thaliana, Brassica napus, Helianthus annuus (Q43469)
Beckmann Christop, B.C.; Rattke Janin, R.J.; Oldham Neil, O.N.; Sperling Petr, S.P.; Heinz Erns, H.E.; Boland Wilhel, B.W.
Characterization of a DELTA8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers
Angew. Chem. Int. Ed. Engl.
41
2298-2300
2002
Helianthus annuus, Helianthus annuus (Q43469)
Ryan, P.R.; Liu, Q.; Sperling, P.; Dong, B.; Franke, S.; Delhaize, E.
A higher plant DELTA8 sphingolipid desaturase with a preference for (Z)-isomer formation confers aluminum tolerance to yeast and plants
Plant Physiol.
144
1968-1977
2007
Stylosanthes hamata (A7Y7E1)
Oura, T.; Kajiwara, S.
Disruption of the sphingolipid DELTA8-desaturase gene causes a delay in morphological changes in Candida albicans
Microbiology
154
3795-3803
2008
Candida albicans, Candida albicans TUA6
Habel, A.; Sperling, P.; Bartram, S.; Heinz, E.; Boland, W.
Conformational studies on the DELTA8(E,Z)-sphingolipid desaturase from Helianthus annuus with chiral fluoropalmitic acids as mechanistic probes
J. Org. Chem.
75
4975-4982
2010
Helianthus annuus
Li, S.F.; Song, L.Y.; Zhang, G.J.; Yin, W.B.; Chen, Y.H.; Wang, R.R.; Hu, Z.M.
Newly identified essential amino acid residues affecting DELTA8-sphingolipid desaturase activity revealed by site-directed mutagenesis
Biochem. Biophys. Res. Commun.
416
165-171
2011
Brassica rapa (G9I7G1)
Song, L.; Zhang, Y.; Li, S.; Hu, J.; Yin, W.; Chen, Y.; Hao, S.; Wang, B.; Wang, R.; Hu, Z.
Identification of the substrate recognition region in the DELTA6-fatty acid and DELTA8-sphingolipid desaturase by fusion mutagenesis
Planta
239
753-763
2014
Ribes nigrum
Li, S.; Zhang, G.; Yuan, Y.; Wang, C.; Gao, W.; Deng, C.; Lu, L.; Hu, Z.
Three homologous genes encoding functional DELTA8-sphingolipid desaturase in Populus tomentosa
Genes Genomics
36
293-301
2014
Populus tomentosa
-
Chen, M.; Markham, J.; Cahoon, E.
Sphingolipid DELTA8 unsaturation is important for glucosylceramide biosynthesis and low-temperature performance in Arabidopsis
Plant J.
69
769-781
2012
Arabidopsis thaliana
Garcia-Maroto, F.; Garrido-Cardenas, J.A.; Michaelson, L.V.; Napier, J.A.; Alonso, D.L.
Cloning and molecular characterisation of a DELTA8-sphingolipid-desaturase from Nicotiana tabacum closely related to DELTA6-acyl-desaturases
Plant Mol. Biol.
64
241-250
2007
Nicotiana tabacum (A4GK73), Nicotiana tabacum
Li, S.; Zhang, G.; Yuan, Y.; Wang, C.; Gao, W.; Deng, C.; Lu, L.; Hu, Z.
Three homologous genes encoding functional DELTA8-sphingolipid desaturase in Populus tomentosa
Genes Genomics
36
293-301
2014
Populus tomentosa
-
Li, S.F.; Zhang, G.J.; Zhang, X.J.; Yuan, J.H.; Deng, C.L.; Hu, Z.M.; Gao, W.J.
Genes encoding DELTA8-sphingolipid desaturase from various plants identification, biochemical functions, and evolution
J. Plant Res.
129
979-987
2016
Cucumis sativus (A0A0A0KA29), Carica papaya (A0A193BIJ7), Ricinus communis (B9RDZ7), Sorghum bicolor (C5XAI0), Vitis vinifera (F6H3N5), Vitis vinifera (F6I678), Brachypodium distachyon (I1IPG5), Glycine max (I1J5P4), Glycine max (I1KXS8), Glycine max (I1MXA6), Prunus persica (M5X146), Prunus persica (M5X679), Prunus persica (M5XCX6), Arabidopsis thaliana (Q3EBF7), Arabidopsis thaliana (Q9ZRP7), Aquilegia vulgaris (Q8LLD7), Borago officinalis (Q9FR82), Triticum aestivum (Q9ZTU8), Triticum aestivum (W5FYY9), Populus tomentosa (W8DT12), Populus tomentosa (W8DT41), Populus tomentosa (W8DTJ8)
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