1.14.19.21: cholesterol 7-desaturase

This is an abbreviated version!
For detailed information about cholesterol 7-desaturase, go to the full flat file.

Reaction

Synonyms

C-7 cholesterol desaturase, C7-Des, cholesterol 7,8-dehydrogenase, DAF-36, DAF-36/Neverland, Des7, Des7p, Neverland, Nvd, PmNvd, Rieske domain oxygenase Neverland, sterol C7(8)-desaturase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.21 cholesterol 7-desaturase

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Results	in table
864	AA Sequence
8	Cloned(Commentary)
26	Cofactor
4	General Information
9	Localization
1	Metals/Ions
1	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
6	Protein Variants
1	Reaction
10	Reference
2	Source Tissue
31	Substrates and Products (Substrate)
1	Subunits
27	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 1.14.19.21 - cholesterol 7-desaturase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

22-cholesten-3beta-ol + NADH + H+

7,22-cholestadiene-3beta-ol + NAD+ + H2O

Tetrahymena thermophila

I7ML19

-

735284

-

-

?

22-cholesten-3beta-ol + NADPH + H+

7,22-cholestadiene-3beta-ol + NADP+ + H2O

Tetrahymena thermophila

I7ML19

-

735284

-

-

?

5alpha-cholest-22-en-3beta-ol + O2 + NADH + H+

5alpha-cholesta-7,22-dien-3beta-ol + NAD+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

5alpha-cholest-22-en-3beta-ol + O2 + NADPH + H+

5alpha-cholesta-7,22-dien-3beta-ol + NADP+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

5alpha-cholestan-3beta-ol + O2 + NADH + H+

5alpha-cholest-7-en-3beta-ol + NAD+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

5alpha-cholestan-3beta-ol + O2 + NADPH + H+

5alpha-cholest-7-en-3beta-ol + NADP+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

cholesta-5,22-dien-3beta-ol + O2 + NADH + H+

cholesta-5,7,22-trien-3beta-ol + NAD+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

cholesta-5,22-dien-3beta-ol + O2 + NADPH + H+

cholesta-5,7,22-trien-3beta-ol + NADP+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

cholestan-3beta-ol + NADH + H+

7-cholesten-3beta-ol + NAD+ + H2O

Tetrahymena thermophila

I7ML19

-

735284

-

-

?

cholestan-3beta-ol + NADPH + H+

7-cholesten-3beta-ol + NADP+ + H2O

Tetrahymena thermophila

I7ML19

-

735284

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NAD+ + H2O

3 entries

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

5 entries

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

9 entries

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NAD+ + H2O

Bombyx mori

Q1JUZ2

-

725431

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NAD+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NAD+ + H2O

Tetrahymena thermophila

I7ML19

-

735284

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Caenorhabditis elegans

Q17938

-

725431

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Ciona intestinalis

F7J186

-

725431

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Danio rerio

Q6DHJ3

-

725431

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Hemicentrotus pulcherrimus

F7J188

-

725431

-

-

?

cholesterol + O2 + NADH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Xenopus laevis

F7J184

-

725431

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Bombyx mori

Q1JUZ2

-

725431

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Caenorhabditis elegans

-

-

723904

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Caenorhabditis elegans

Q17938

-

725431

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Ciona intestinalis

F7J186

-

725431

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Danio rerio

Q6DHJ3

-

725431

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Hemicentrotus pulcherrimus

F7J188

-

725431

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Tetrahymena thermophila

-

-

725923

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Tetrahymena thermophila

I7ML19

-

735284

-

-

?

cholesterol + O2 + NADPH + H+

cholesta-5,7-dien-3beta-ol + NADP+ + H2O

Xenopus laevis

F7J184

-

725431

-

-

?