1.14.19.21: cholesterol 7-desaturase

This is an abbreviated version!
For detailed information about cholesterol 7-desaturase, go to the full flat file.

Reaction

Synonyms

C-7 cholesterol desaturase, C7-Des, cholesterol 7,8-dehydrogenase, DAF-36, DAF-36/Neverland, Des7, Des7p, Neverland, Nvd, PmNvd, Rieske domain oxygenase Neverland, sterol C7(8)-desaturase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.21 cholesterol 7-desaturase

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Results	in table
864	AA Sequence
8	Cloned(Commentary)
26	Cofactor
4	General Information
9	Localization
1	Metals/Ions
1	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
10	Organism
4	Pathway
6	Protein Variants
1	Reaction
10	Reference
2	Source Tissue
31	Substrates and Products (Substrate)
1	Subunits
27	Synonyms
1	Systematic Name

General Information

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General Information on EC 1.14.19.21 - cholesterol 7-desaturase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Penaeus monodon

A0A2I4PEL8

silencing of PmNvd transcript in shrimp by specific double-stranded RNA (dsNvd) leads to prolonged molt duration with abnormal molting progression, i.e. the molting process got stuck at early premolt stage. In addition, the 20-hydroxyecdysone titer in hemolymph of dsNvd-injected shrimps is significantly reduced compared with that in NaCl-injected shrimps. Phenotype, overview

744745

metabolism

Penaeus monodon

A0A2I4PEL8

the cholesterol 7,8-dehydrogenase catalyzes the first step of the ecdysteroid biosynthesis converting cholesterol to 7-dehydrocholesterol

744745

physiological function

2 entries

physiological function

Caenorhabditis elegans

-

the enzyme regulates DAF-12 activities for reproductive development and longevity by controlling dafachronic acids production

723904

physiological function

Penaeus monodon

A0A2I4PEL8

function of the enzyme in the molting process and molt regulation, crucial role of PmNvd in molt progression, particularly during the initiation of premolt phase via the regulation of ecdysteroid production

744745