1.14.19.20: DELTA7-sterol 5(6)-desaturase

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For detailed information about DELTA7-sterol 5(6)-desaturase, go to the full flat file.

Reaction

Synonyms

5-DES, 5alpha-cholest-7-en-3beta-ol:oxygen DELTA5-oxidoreductase, C-5 sterol desaturase, C-5(6) sterol desaturase, Delta-7-sterol 5-desaturase, DELTA7-sterol 5-desaturase, DELTA7-sterol C56-desaturase, DELTA7-sterol DELTA5-dehydrogenase, DELTA7-sterol-C-5-desaturase, DELTA7-sterol-C5 (6)-desaturase, DELTA7-sterol-C5(6)-desaturase, DELTA7-sterol-C5-desaturase, DES5A, Des5Ap, Dhcr7, DWARF7, EC 1.14.21.6, EC 1.3.3.2, ERG 3, ERG3, erg32, Erg3p, FvC5SD, Lathosterol 5-desaturase, lathosterol oxidase, oxidase, lathosterol, Sc5d, SC5DL, SCSD, STE1, sterol C5-desaturase, sterol DELTA5,6-desaturase, sterol DELTA7-reductase, Sterol-C5-desaturase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

                1.14.19.20 DELTA7-sterol 5(6)-desaturase

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2	Activating Compound
110	AA Sequence
1	CAS Registry Number
18	Cloned(Commentary)
40	Cofactor
16	Disease/ Diagnostics
14	General Information
1	General Stability
12	IC50 Value
40	Inhibitors
18	KM Value [mM]
21	Localization
4	Metals/Ions
1	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
46	Organism
16	Pathway
2	pH Optimum
56	Protein Variants
2	Purification (Commentary)
3	Reaction
10	Reaction Type
44	Reference
24	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
69	Substrates and Products (Substrate)
1	Subunits
68	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.14.19.20 - DELTA7-sterol 5(6)-desaturase

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SYSTEMATIC NAME

IUBMB Comments

DELTA7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating

This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta7-sterols, to yield the corresponding Delta5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.