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1.14.19.20: DELTA7-sterol 5(6)-desaturase

This is an abbreviated version!
For detailed information about DELTA7-sterol 5(6)-desaturase, go to the full flat file.

Word Map on EC 1.14.19.20

Reaction

a DELTA7-sterol
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a DELTA5,7-sterol
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

5-DES, 5alpha-cholest-7-en-3beta-ol:oxygen DELTA5-oxidoreductase, C-5 sterol desaturase, C-5(6) sterol desaturase, Delta-7-sterol 5-desaturase, DELTA7-sterol 5-desaturase, DELTA7-sterol C56-desaturase, DELTA7-sterol DELTA5-dehydrogenase, DELTA7-sterol-C-5-desaturase, DELTA7-sterol-C5 (6)-desaturase, DELTA7-sterol-C5(6)-desaturase, DELTA7-sterol-C5-desaturase, DES5A, Des5Ap, Dhcr7, DWARF7, EC 1.14.21.6, EC 1.3.3.2, ERG 3, ERG3, erg32, Erg3p, FvC5SD, Lathosterol 5-desaturase, lathosterol oxidase, oxidase, lathosterol, Sc5d, SC5DL, SCSD, STE1, sterol C5-desaturase, sterol DELTA5,6-desaturase, sterol DELTA7-reductase, Sterol-C5-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.20 DELTA7-sterol 5(6)-desaturase

IC50 Value

IC50 Value on EC 1.14.19.20 - DELTA7-sterol 5(6)-desaturase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00033
(3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-ol
Homo sapiens
-
inhibition of total cholesterol production
0.00045
(3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-yl acetate
Homo sapiens
-
inhibition of total cholesterol production
0.0007
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-ol
Homo sapiens
-
inhibition of total cholesterol production
0.00091
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-yl acetate
Homo sapiens
-
inhibition of total cholesterol production
0.00116
(3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-ol
Homo sapiens
-
inhibition of total cholesterol production
0.0011
(3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-yl acetate
Homo sapiens
-
inhibition of total cholesterol production
0.00105
(3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-ol
Homo sapiens
-
inhibition of total cholesterol production
0.00095
(3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-yl acetate
Homo sapiens
-
inhibition of total cholesterol production
2
1,10-phenanthroline
Zea mays
-
at pH 7.6 and 30°C
0.015
cyanide
Zea mays
-
at pH 7.6 and 30°C
0.008
CYC (cyctochrome c)
Zea mays
-
at pH 7.6 and 30°C
-
0.5
Salicylhydroxamic acid
Zea mays
-
at pH 7.6 and 30°C