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1.14.19.18: sphingolipid 8-(E)-desaturase

This is an abbreviated version!
For detailed information about sphingolipid 8-(E)-desaturase, go to the full flat file.

Reaction

a (4E)-sphing-4-enine ceramide
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (4E,8E)-sphing-4,8-dienine ceramide
+ 2 ferricytochrome b5 + 2 H2O

Synonyms

8 fatty acid desaturase, 8-sphingolipid desaturase, D8A, D8B, D8C, D8D, DELTA8-sphingolipid desaturase, DesB, SLD, sphinganine DELTA8-desaturase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.19 With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
                1.14.19.18 sphingolipid 8-(E)-desaturase

Reference

Reference on EC 1.14.19.18 - sphingolipid 8-(E)-desaturase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Takakuwa, N.; Kinoshita, M.; Oda, Y.; Ohnishi, M.
Isolation and characterization of the genes encoding DELTA8-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis
Curr. Microbiol.
45
459-461
2002
Kluyveromyces lactis (Q8NKG8), Lachancea kluyveri (Q8NKG9), Kluyveromyces lactis IFO 1090 (Q8NKG8), Lachancea kluyveri IFO 1685 (Q8NKG9)
Manually annotated by BRENDA team
Tonon, T.; Sayanova, O.; Michaelson, L.V.; Qing, R.; Harvey, D.; Larson, T.R.; Li, Y.; Napier, J.A.; Graham, I.A.
Fatty acid desaturases from the microalga Thalassiosira pseudonana
FEBS J.
272
3401-3412
2005
Thalassiosira pseudonana (Q4G2T2)
Manually annotated by BRENDA team
Oura, T.; Kajiwara, S.
Disruption of the sphingolipid DELTA8-desaturase gene causes a delay in morphological changes in Candida albicans
Microbiology
154
3795-3803
2008
Candida albicans
Manually annotated by BRENDA team
Li, S.F.; Song, L.Y.; Zhang, G.J.; Yin, W.B.; Chen, Y.H.; Wang, R.R.; Hu, Z.M.
Newly identified essential amino acid residues affecting DELTA8-sphingolipid desaturase activity revealed by site-directed mutagenesis
Biochem. Biophys. Res. Commun.
416
165-171
2011
Brassica rapa subsp. oleifera (G9I7G1)
Manually annotated by BRENDA team
Song, L.; Zhang, Y.; Li, S.; Hu, J.; Yin, W.; Chen, Y.; Hao, S.; Wang, B.; Wang, R.; Hu, Z.
Identification of the substrate recognition region in the DELTA6-fatty acid and DELTA8-sphingolipid desaturase by fusion mutagenesis
Planta
239
753-763
2014
Ribes nigrum
Manually annotated by BRENDA team
Li, S.; Zhang, G.; Yuan, Y.; Wang, C.; Gao, W.; Deng, C.; Lu, L.; Hu, Z.
Three homologous genes encoding functional DELTA8-sphingolipid desaturase in Populus tomentosa
Genes Genomics
36
293-301
2014
Populus tomentosa (W8DT12), Populus tomentosa (W8DTJ8)
-
Manually annotated by BRENDA team
Li, S.; Song, L.; Yin, W.; Chen, Y.; Chen, L.; Li, J.; Wang, R.; Hu, Z.
Isolation and functional characterisation of the genes encoding DELTA8-sphingolipid desaturase from Brassica rapa
J. Genet. Genomics
39
47-59
2012
Brassica rapa (G9I7G1), Brassica rapa (H6U4I9), Brassica rapa (H6U4J0), Brassica rapa (H6U4J1)
Manually annotated by BRENDA team