1.14.19.12: acyl-lipid omega-(9-4) desaturase

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For detailed information about acyl-lipid omega-(9-4) desaturase, go to the full flat file.

Reaction

+ 2 ferrocytochrome b5 +

+ 2 H+ =

+ 2 ferricytochrome b5 + 2 H2O

Synonyms

acyl-lipid 7-desaturase, acyl-lipid omega-13 desaturase, DES, omega13 desaturase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

1.14.19.12 acyl-lipid omega-(9-4) desaturase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Cofactor
11	Natural Substrates/ Products (Substrates)
2	Organism
1	Pathway
2	Reaction
2	Reference
11	Substrates and Products (Substrate)
6	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.19.12 - acyl-lipid omega-(9-4) desaturase

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acyl-[glycerolipid],ferrocytochrome b5:oxygen oxidoreductase [omega(9-4),omega(9-5) cis-dehydrogenating]

The enzyme, characterized from the green alga Chlamydomonas reinhardtii, is a front-end desaturase that introduces a cis double bond in omega9 unsaturated C18 or C20 fatty acids incorporated into lipids, at a position 4 carbon atoms from the existing omega9 bond, towards the carboxy end of the fatty acid (at the omega13 position). When acting on 20:2Delta(11,14) and 20:3Delta(11,14,17) substrates it introduces the new double bond between carbons 7 and 8. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor for the active site of the desaturase.