1.14.19.1: stearoyl-CoA 9-desaturase
This is an abbreviated version!
For detailed information about stearoyl-CoA 9-desaturase, go to the full flat file.
Word Map on EC 1.14.19.1
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1.14.19.1
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sickle
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cardiac
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children
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ventricular
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pain
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hemoglobin
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arrhythmia
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vaso-occlusive
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transfusion
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anemia
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infarct
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cardiomyopathy
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episode
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cardiovascular
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coronary
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myocardial
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artery
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stratification
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polyunsaturated
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ejection
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hydroxyurea
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stroke
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monounsaturated
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crises
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chest
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defibrillator
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desaturation
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lipogenesis
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arrhythmogenic
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tachycardia
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hemoglobinopathy
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all-cause
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cardioverter
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pufas
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cardioverter-defibrillator
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desaturases
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electrocardiogram
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lipogenic
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transfused
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pharmacology
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thalassemia
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12-lead
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palmitoleic
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agriculture
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tachyarrhythmias
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caregiver
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out-of-hospital
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resynchronization
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medicine
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transcranial
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syncope
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drug development
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holter
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alloimmunization
- 1.14.19.1
-
sickle
- cardiac
- children
- ventricular
- pain
- hemoglobin
- arrhythmia
-
vaso-occlusive
-
transfusion
- anemia
- infarct
- cardiomyopathy
- episode
- cardiovascular
- coronary
- myocardial
- artery
-
stratification
-
polyunsaturated
-
ejection
- hydroxyurea
- stroke
-
monounsaturated
- crises
- chest
-
defibrillator
-
desaturation
-
lipogenesis
-
arrhythmogenic
- tachycardia
- hemoglobinopathy
-
all-cause
-
cardioverter
-
pufas
-
cardioverter-defibrillator
-
desaturases
-
electrocardiogram
-
lipogenic
-
transfused
- pharmacology
- thalassemia
-
12-lead
-
palmitoleic
- agriculture
- tachyarrhythmias
-
caregiver
-
out-of-hospital
-
resynchronization
- medicine
-
transcranial
- syncope
- drug development
-
holter
-
alloimmunization
Reaction
Synonyms
ACOD4, acyl coenzyme A desaturase, acyl-CoA desaturase, delta-9 desaturase, DELTA9 desaturase, DELTA9 fatty acid desaturase, DELTA9 terminal desaturase, DELTA9-acyl CoA desaturase, DELTA9-desaturase, DELTA9-fatty-acid desaturase, DELTA9D, DesA3, desaturase 9, Dpu-DELTA9-KPSE, EC 1.14.99.5, eicosatrienoyl-CoA desaturase, FAD9, fatty acid 9-desaturase, fatty acid DELTA9-desaturase, fatty acid desaturase, fatty acyl CoA DELTA9-desaturase, fatty acyl DELTA9-desaturase, fatty acyl-CoA desaturase, hSCD1, hSCD5, long-chain fatty acid DELTA9-desaturase, membrane-bound stearoyl-CoA DELTA9 desaturase, NPVE desaturase, palmitoyl CoA desaturase, palmitoyl-CoA desaturase, SCD, SCD-1, SCD-2, SCD-3, SCD-4, SCD1, SCD2, SCD3, SCD4, SCD5, stearoyl CoA desaturase, stearoyl coenzyme A desaturase, stearoyl coenzyme-A desaturase 1, stearoyl-ACP DELTA9 desaturase, stearoyl-CoA (DELTA8) desaturase, stearoyl-CoA desaturase, stearoyl-CoA desaturase 1, stearoyl-CoA desaturase 2, stearoyl-CoA desaturase enzyme-1, stearoyl-CoA desaturase-1, stearoyl-CoA desaturase-2, stearoyl-CoA desaturase-3, stearoyl-CoA desaturase-4, stearoyl-CoA desaturase-5, stearoyl-CoA desaturase1, stearoyl-CoA desaturase2, stearoyl-coenzyme A desaturase, stearoyl-coenzyme A desaturase-1, stearyl coenzyme A desaturase, stearyl-CoA desaturase, TkSCD-1, TkSCD-2
ECTree
1.14.19.1 stearoyl-CoA 9-desaturaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.14.19.1 - stearoyl-CoA 9-desaturase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
the level of SCD protein expression in cumulus cells does not change when cumulus-oocyte complexes (COCs) are exposed to saturated stearic acid during maturation
enzyme SCD1 is upregulated in enriched liver tumor-initiating cell populations and sporadically expressed in human hepatocellular carcinoma specimens, elevated SCD1 expression in hepatocellular carcinoma tumors
stably expressing the full-length HCV genotype 1b replicon with a S2204I adaptive mutation in NS5A (Huh7.5 FGR)
upregulation of SCD1 of self-renewing liver cancer cells in chemoresistant hepatospheres
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normal lung fibroblasts WI38 and the derived SV40-tranformed strain cells SV40-WI38, SCD protein content 3.3fold increased in SV40-WI38 cells compared to WI38 cells
additional information
isozyme SCD1 is dramatically induced during 3T3L1 differentiation
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subcutaneous, gene expression very low in tissue from the short-fed steers fed the corn-based diet
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Angus and Wagyu steers consuming high-roughage diets exhibit large differences in adipose tissue fatty acid composition, but there are no differences in terminal measures of SCD activity or gene expression
hSCD1, sevenfold higher mRNA level in adipose tissue than in liver, real-time PCR
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injection of Scd1 sequence-specific antisense oligodeoxynucleotides decreases Scd1 gene expression in brown and white adipose tissue as well as in liver
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a reduced protein diet does not change protein expression and activity in subcutaneous adipose tissue
specific high expression level of isozyme SCD5, equally distributed between white and gray matter
equivalent levels of hSCD1 and hSCD5 mRNA in adult brain, real-time PCR
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post mortem brains, gender- and age-related quantitative expression analysis of SCD in brains in relation to the fatty acid composition, overview
exclusively expressed in heart, no repression by dietary polyunsaturated fatty acids, induction in SCD1-deficient animals
isozyme SCD4 is expressed mainly in the heart
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harboring the pFKI389neo/NS3-39/5.1 subgenomic replicon (Huh7 SGR, genotype 1b)
hSCD1, sevenfold higher mRNA level in adipose tissue than in liver, real-time PCR
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hepatic SCD1 activity index correlates negatively with liver fat and positively with insulin sensitivity, overview
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24 microg/day leptin treatment for 4 days with or without exogenous insulin treatment of ob/ob mice suppresses mRNA, SCD protein undetectable in leptin-treated ob/ob mice with or without exogenous insulin treatment
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5fold higher expression and 40% increase in enzyme activity in hepatic microsomes in tristearin-fed compared with trioleate-fed mice
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injection of Scd1 sequence-specific antisense oligodeoxynucleotides decreases Scd1 gene expression in brown and white adipose tissue as well as in liver
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on a high-fat diet the livers of wild-type mice become steatotic, stearoyl-CoA desaturase deficiency protects against liver steatosis, on a chow diet the livers of wild-type and SCD1-/- mice are normal and of similar mass
SCD1 is highly expressed and significantly changed by various diets, where part of the medium chain triacylglycerol oil in control diet was replaced with 1.1% fungal oil, 1.9% fish oil or both 1.1% fungal and 1.9% fish oil
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treatment with Scd1 sequence-specific antisense oligodeoxynucleotide decreases mRNA and protein, real-time PCR
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treatment with Scd1 sequence-specific antisense oligodeoxynucleotide decreases mRNA and protein, real-time PCR
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SCD1 is highly expressed and significantly changed by various diets, where part of the medium chain triacylglycerol oil in control diet was replaced with 1.1% fungal oil, 1.9% fish oil or both 1.1% fungal and 1.9% fish oil
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437644, 437645, 437647, 437648, 437649, 437654, 437655, 437657, 437658, 437662, 437664, 695566, 696680, 696683, 696690, 697777, 697824, 701423, 716200, 727140, 734115
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mRNA decreased by 80% following 2 injections of Scd1 sequence-specific antisense oligodeoxynucleotide over 5 days, real-time PCR
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a reduced protein diet significantly increases protein expression and activity
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immunocytochemistry of day 8 myotubes using an anti-SCD1 antibody, SCD1 mRNA levels are increased 2.8fold and protein levels are increased 5.7fold in myotubes from obese compared to lean subjects
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C57Bl/B6 mice under low-fat diet have 3 to 4 times more SCD1 transcript than 129S6/SvEvTac mice under low-fat diet, mRNA increased 3fold by high-fat feeding of 129S6/SvEvTac mice and 1.5fold by high-fat feeding of C57Bl/B6 mice
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increased relative expression level in obese insulin-resistent ZDF rats compared to lean insulin-sensitive rats
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long-term glucose oversupply induces rapid increase in SCD expression and enzyme activity
high expression level of isozyme SCD1
additional information
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limited expression in adult tissues, detected in normal fibroblasts and cancer cell
additional information
isozyme SCD1 is abundantly expressed in lipogenic tissues
additional information
isozyme SCD1 is abundantly expressed in lipogenic tissues
additional information
isozyme SCD5 is predominantly expressed in the brain and pancreas
additional information
isozyme SCD5 is predominantly expressed in the brain and pancreas
additional information
mRNA expression levels of SCD1 in tumor tissues markedly elevated compared to that in adjacent non-tumor tissues
additional information
isozyme tissue expression analysis, isoyzme SCD3 shows expression in several tissues
additional information
isozyme tissue expression analysis, isoyzme SCD3 shows expression in several tissues
additional information
isozyme tissue expression analysis, isoyzme SCD3 shows expression in several tissues
additional information
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isozyme tissue expression analysis, isoyzme SCD3 shows expression in several tissues
additional information
SCD2 isoform is ubiquitously expressed in most tissues except liver
additional information
SCD2 isoform is ubiquitously expressed in most tissues except liver
additional information
SCD2 isoform is ubiquitously expressed in most tissues except liver
additional information
SCD2 isoform is ubiquitously expressed in most tissues except liver
additional information
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stearoyl-CoA desaturase deficient mice have very low levels of triglycerides in the VLDL and LDL fractions relative to the wild-type
additional information
isozyme SCD1 is ubiquitously expressed and shows higher expression in metabolic tissues
additional information
isozyme SCD1 is ubiquitously expressed and shows higher expression in metabolic tissues
additional information
isozyme SCD1 is ubiquitously expressed and shows higher expression in metabolic tissues
additional information
isozyme SCD1 is ubiquitously expressed and shows higher expression in metabolic tissues
additional information
isozyme SCD2 is ubiquitously expressed in most tissues except adult mouse liver
additional information
isozyme SCD2 is ubiquitously expressed in most tissues except adult mouse liver
additional information
isozyme SCD2 is ubiquitously expressed in most tissues except adult mouse liver
additional information
isozyme SCD2 is ubiquitously expressed in most tissues except adult mouse liver
additional information
isozyme SCD3 is mainly expressed in Harderian gland, preputial gland, and in mature sebocytes of skin
additional information
isozyme SCD3 is mainly expressed in Harderian gland, preputial gland, and in mature sebocytes of skin
additional information
isozyme SCD3 is mainly expressed in Harderian gland, preputial gland, and in mature sebocytes of skin
additional information
isozyme SCD3 is mainly expressed in Harderian gland, preputial gland, and in mature sebocytes of skin
additional information
the enzyme is highly expressed in lipogenic tissues, such as liver and adipose tissue
additional information
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decreased mRNA levels in epididymal fat pads after 2 injections of Scd1 sequence-specific antisense oligodeoxynucleotide over 5 days
