1.14.18.8: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase

This is an abbreviated version, for detailed information about 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase, go to the full flat file.

Reaction

7alpha-hydroxycholest-4-en-3-one
+ 2 ferrocytochrome b5 + 2 H+ +
O2
=
7alpha,12alpha-dihydroxycholest-4-en-3-one
+ 2 ferricytochrome b5 +
H2O

Synonyms

7alpha-hydroxy-4-cholest-3-on3 12alpha-monooxygenase, 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, CYP8B1, HCO 12alpha-hydroxylase, sterol 12alpha-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.8 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase