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1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase

This is an abbreviated version!
For detailed information about dihydroceramide fatty acyl 2-hydroxylase, go to the full flat file.

Reaction

a dihydroceramide
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (2'R)-2'-hydroxydihydroceramide
+ 2 ferricytochrome b5 +
H2O

Synonyms

AtFAH1, FAH1, FAH2, fatty acid 2-hydroxylase 1, plant sphingolipid fatty acid 2-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.7 dihydroceramide fatty acyl 2-hydroxylase

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Resultsin table
1Activating Compound
4AA Sequence
3Cofactor
4General Information
6Organism
1Pathway
1Reaction
6Reference
12Synonyms
1Systematic Name

Systematic Name

Systematic Name on EC 1.14.18.7 - dihydroceramide fatty acyl 2-hydroxylase

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SYSTEMATIC NAME
IUBMB Comments
dihydroceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating)
The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.