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1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase

This is an abbreviated version!
For detailed information about dihydroceramide fatty acyl 2-hydroxylase, go to the full flat file.

Reaction

a dihydroceramide
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a (2'R)-2'-hydroxydihydroceramide
+ 2 ferricytochrome b5 +
H2O

Synonyms

AtFAH1, FAH1, FAH2, fatty acid 2-hydroxylase 1, plant sphingolipid fatty acid 2-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.7 dihydroceramide fatty acyl 2-hydroxylase

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Resultsin table
1Activating Compound
4AA Sequence
3Cofactor
4General Information
6Organism
1Pathway
1Reaction
6Reference
12Synonyms
1Systematic Name

Reference

Reference on EC 1.14.18.7 - dihydroceramide fatty acyl 2-hydroxylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mitchell, A.; Martin, C.
Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids
J. Biol. Chem.
272
28281-28288
1997
Arabidopsis thaliana (O48916)
Manually annotated by BRENDA team
Nagano, M.; Ihara-Ohori, Y.; Imai, H.; Inada, N.; Fujimoto, M.; Tsutsumi, N.; Uchimiya, H.; Kawai-Yamada, M.
Functional association of cell death suppressor, Arabidopsis Bax inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b5
Plant J.
58
122-134
2009
Arabidopsis thaliana, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Nagano, M.; Takahara, K.; Fujimoto, M.; Tsutsumi, N.; Uchimiya, H.; Kawai-Yamada, M.
Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses
Plant Physiol.
159
1138-1148
2012
Arabidopsis thaliana (O48916), Arabidopsis thaliana (Q9SUC5)
Manually annotated by BRENDA team
Nagano, M.; Ishikawa, T.; Ogawa, Y.; Iwabuchi, M.; Nakasone, A.; Shimamoto, K.; Uchimiya, H.; Kawai-Yamada, M.
Arabidopsis Bax inhibitor-1 promotes sphingolipid synthesis during cold stress by interacting with ceramide-modifying enzymes
Planta
240
77-89
2014
Saccharomyces cerevisiae
Manually annotated by BRENDA team