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1.14.18.4: phosphatidylcholine 12-monooxygenase

This is an abbreviated version!
For detailed information about phosphatidylcholine 12-monooxygenase, go to the full flat file.

Word Map on EC 1.14.18.4

Reaction

a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine
+ 2 ferrocytochrome b5 +
O2
+ 2 H+ =
a 1-acyl-2-[(12R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine
+ 2 ferricytochrome b5 +
H2O

Synonyms

castor DELTA12-hydroxylase, CFAH12, CFAH12 protein, CpFAH, CpFAH12, DELTA12 oleate hydroxylase, EC 1.14.13.26, FAH, FAH12, LFAH12, oleate 12-hydroxylase, oleate DELTA12-hydroxylase, oleate hydroxylase, oleoyl-12-hydroxylase, oxygenase, oleate DELTA12-mono, ricinoleic acid synthase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.18.4 phosphatidylcholine 12-monooxygenase

Natural Substrates Products

Natural Substrates Products on EC 1.14.18.4 - phosphatidylcholine 12-monooxygenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2
1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + ferricytochrome b5
show the reaction diagram
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2
1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
show the reaction diagram
-
-
-
-
?
cis-oleic acid + reduced acceptor + O2
ricinoleic acid + acceptor + H2O
show the reaction diagram
oleate + ferrocytochrome P-450 + H+ + O2
12-hydroxy-oleate + ferricytochrome P-450 + H2O
show the reaction diagram
the enzyme is primarily a fatty acid hydroxylase, rather than a bifunctional oleate 12-hydroxylase-desaturase, involved in ricinoleic acid biosynthesis, overview
-
-
?
oleic acid esterified to membrane lipid phosphatidylcholine + reduced acceptor + H+ + O2
hydroxy fatty acids in triacylglycerol + acceptor + H2O
show the reaction diagram
D2CPE1
-
-
-
?
additional information
?
-