1.14.18.4: phosphatidylcholine 12-monooxygenase
This is an abbreviated version!
For detailed information about phosphatidylcholine 12-monooxygenase, go to the full flat file.
Word Map on EC 1.14.18.4
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1.14.18.4
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triacylglycerols
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ricinus
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communis
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bean
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desaturase
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purpurea
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claviceps
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phospholipase
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fendleri
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oilseed
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linoleate
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lesquerella
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seed-specific
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desaturation
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lesquerolic
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synthesis
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petrochemical
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18-carbon
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condensing
- 1.14.18.4
- triacylglycerols
- ricinus
- communis
- bean
-
desaturase
- purpurea
-
claviceps
- phospholipase
- fendleri
-
oilseed
- linoleate
- lesquerella
-
seed-specific
-
desaturation
-
lesquerolic
- synthesis
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petrochemical
-
18-carbon
-
condensing
Reaction
+ 2 ferrocytochrome b5 + + 2 H+ = + 2 ferricytochrome b5 +
Synonyms
castor DELTA12-hydroxylase, CFAH12, CFAH12 protein, CpFAH, CpFAH12, DELTA12 oleate hydroxylase, EC 1.14.13.26, FAH, FAH12, LFAH12, oleate 12-hydroxylase, oleate DELTA12-hydroxylase, oleate hydroxylase, oleoyl-12-hydroxylase, oxygenase, oleate DELTA12-mono, ricinoleic acid synthase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.14.18.4 - phosphatidylcholine 12-monooxygenase
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REACTION DIAGRAM
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2
1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + ferricytochrome b5
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2
1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + ferricytochrome b5 + H2O
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oleate + ferrocytochrome P-450 + H+ + O2
12-hydroxy-oleate + ferricytochrome P-450 + H2O
the enzyme is primarily a fatty acid hydroxylase, rather than a bifunctional oleate 12-hydroxylase-desaturase, involved in ricinoleic acid biosynthesis, overview
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oleic acid esterified to membrane lipid phosphatidylcholine + reduced acceptor + H+ + O2
hydroxy fatty acids in triacylglycerol + acceptor + H2O
D2CPE1
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1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + ferricytochrome b5
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1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + ferrocytochrome b5 + O2
1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + ferricytochrome b5
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ricinoleic acid + acceptor + H2O
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cis-oleic acid + reduced acceptor + O2
ricinoleic acid + acceptor + H2O
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cis-oleic acid + reduced acceptor + O2
ricinoleic acid + acceptor + H2O
Ricinus communis OLE-1
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biosynthesis of ricinoleic acid in Claviceps purpurea is catalyzed by the fungal desaturase-like hydroxylase
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additional information
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in Lesquerella fendleri ricinoleic acid is efficiently elongated to lesquerolic acid in a reaction catalyzed by a condensing enzyme specific to hydroxy fatty acids
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