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0.035
(+)-gallocatechin-3-O-gallate
Agaricus bisporus
-
competitive inhibition
0.034
(-)-epigallocatechin-3-O-gallate
Agaricus bisporus
-
competitive inhibition
0.25
(1E,4E)-1,5-bis(2-fluoro-4-methoxyphenyl)penta-1,4-dien-3-one
Agaricus bisporus
-
IC50 above 0.25 mM
0.25
(1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one
Agaricus bisporus
-
IC50 above 0.25 mM
0.25
(1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
Agaricus bisporus
-
IC50 above 0.25 mM
0.298
(2-([4-(4-methoxy-benzyloxy)-benzylidene]-hydrazono)-4-oxothiazolidin-5-ylidene)-acetic acid methyl ester
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
0.0498
(2-[(5-methyl-furan-2-ylmethylene)-hydrazono]-4-oxothiazolidin-5-ylidene)-acetic acid methyl ester
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
1
(2E)-3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide
Agaricus bisporus
-
IC50 above 1 mM
0.35
(2E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxybenzyl)prop-2-enamide
Agaricus bisporus
-
-
1
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dihydroxyphenyl)ethyl]prop-2-enamide
Agaricus bisporus
-
IC50 above 1 mM
0.6
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]prop-2-enamide
Agaricus bisporus
-
-
0.25
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
Agaricus bisporus
-
-
0.028 - 0.2781
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
0.3218
(2E)-3-(3,4-dimethoxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
1
(2E)-3-(4-chlorophenyl)-N-[2-(4-chlorophenyl)ethyl]prop-2-enamide
Agaricus bisporus
-
IC50 above 1 mM
0.35
(2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.03
(2E)-3-(4-hydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide
Agaricus bisporus
-
-
0.5
(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
-
1
(2E)-3-(4-methoxyphenyl)-N-(1-phenylethyl)prop-2-enamide
Agaricus bisporus
-
IC50 above 1 mM
1
(2E)-3-(4-methoxyphenyl)-N-(2-phenylethyl)prop-2-enamide
Agaricus bisporus
-
IC50 above 1 mM
0.42
(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
-
0.1
(2E)-3-phenyl-N-(1-phenylethyl)prop-2-enamide
Agaricus bisporus
-
IC50 above 0.1 mM
0.1
(2E)-3-phenyl-N-(2-phenylethyl)prop-2-enamide
Agaricus bisporus
-
IC50 above 0.1 mM
2.1
(2E)-3-phenylprop-2-enoic acid
Agaricus bisporus
-
-
12.05 - 20
(2E)-but-2-enoic acid
0.35
(2E)-N-(3,4-dihydroxybenzyl)-3-(3,4-dihydroxyphenyl)prop-2-enamide
Agaricus bisporus
-
-
0.1
(2E)-N-(4-chlorobenzyl)-3-phenylprop-2-enamide
Agaricus bisporus
-
IC50 above 0.1 mM
0.25
(2E)-N-benzyl-3-(3,4-dihydroxyphenyl)prop-2-enamide
Agaricus bisporus
-
-
0.028
(2E)-N-benzyl-3-(4-hydroxyphenyl)prop-2-enamide
Agaricus bisporus
-
-
1
(2E)-N-benzyl-3-(4-methoxyphenyl)prop-2-enamide
Agaricus bisporus
-
IC50 above 1 mM
0.1
(2E)-N-benzyl-3-phenylprop-2-enamide
Agaricus bisporus
-
IC50 above 0.1 mM
0.1
(2E)-N-[2-(4-chlorophenyl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
Agaricus bisporus
-
IC50 above 0.1 mM
1
(2E)-N-[2-(4-chlorophenyl)ethyl]-3-phenylprop-2-enamide
Agaricus bisporus
-
IC50 above 1 mM
0.0054
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(3-hydroxy-4-methoxyphenyl)prop-2-enamide
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.008 - 0.216
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
0.008
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0238
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-methoxyphenyl)prop-2-enamide
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0404
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-phenylprop-2-enamide
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.9 - 4.95
(2E,4E)-hexa-2,4-dienoic acid
0.25
(2E,6E)-2,6-bis[(4-chlorophenyl)methylidene]cyclohexanone
Agaricus bisporus
-
IC50 above 0.25 mM
0.25
(2E,6E)-2,6-bis[(4-hydroxyphenyl)methylidene]cyclohexanone
Agaricus bisporus
-
IC50 above 0.25 mM
0.24
(2R,3R)-taxifolin
Agaricus bisporus
-
-
0.35
(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.35
(2Z)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.1152
(2Z)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.35
(2Z)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.35
(2Z)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.1213
(2Z)-3-(4-hydroxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.35
(2Z)-3-(4-methoxyphenyl)prop-2-enoic acid
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.35
(2Z)-3-phenylprop-2-enoic acid
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0501
(4-oxo-2-[(1H-pyrrol-2-ylmethylene)-hydrazono]-thiazolidin-5-ylidene)-acetic acid methyl ester
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
0.208
(4-oxo-2-[(3-phenyl-allylidene)-hydrazono]-thiazolidin-5-ylidene)-acetic acid methyl ester
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
1.85
(S)-imperanene
Homo sapiens
-
nearly as effective as arbutin
0.07905
1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one
Agaricus bisporus
-
-
0.00015
1-(1,4-diacetylphenyl)dithiosemicarbazide
Agaricus bisporus
-
-
0.022
1-(1-(2,4,6-trihydroxyphenyl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00058
1-(1-(2,4-dihydroxyphenyl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00052
1-(1-(4-bromophenyl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00017
1-(1-(4-fluorophenyl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00031
1-(1-(4-hydroxyphenyl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.001
1-(1-(4-isopropylphenyl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00011
1-(1-(4-methoxyphenyl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00042
1-(1-(4-methoxyphenyl)propan-2-ylidene)-thiosemicarbazide
Agaricus bisporus
-
-
0.00042
1-(1-(4-methoxyphenyl)propan-2-ylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00088
1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00082
1-(1-(pyridin-3-yl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00014
1-(1-(thiophen-2-yl)ethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00027
1-(1-p-tolylethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00034
1-(1-phenylethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00024 - 0.012
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
0.00085
1-(2,5-dimethyl-1H-pyrrol-1-yl)thiourea
Agaricus bisporus
-
-
0.0555
1-(2-hydroxy-1,2-diphenylethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.1
1-(2-oxo-1,2-diphenylethylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00062
1-(3-methylbutylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.0151
1-(3-oxocyclohexylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.0027
1-(3-phenylallylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00054
1-(4-(4-hydroxyphenyl)butan-2-ylidene)-thiosemicarbazide
Agaricus bisporus
-
-
0.00054
1-(4-(4-hydroxyphenyl)butan-2-ylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.0027
1-(4-bromophenyl)-3-hydroxyurea
Agaricus bisporus
-
-
0.99
1-(4-fluorophenyl)-ethanone
Agaricus bisporus
-
-
2
1-(4-methoxyphenyl)-ethanone
Agaricus bisporus
-
-
0.0115
1-(4-methylpent-3-en-2-ylidene) thiosemicarbazide
Agaricus bisporus
-
-
0.001
1-(but-2-enylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.00028
1-(butan-2-ylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.000086 - 0.00011
1-(propan-2-ylidene)thiosemicarbazide
0.15
1-(thiophen-2-yl)-ethanone
Agaricus bisporus
-
-
0.00095
1-cyclohexylidenethiosemicarbazide
Agaricus bisporus
-
-
0.000075 - 0.0006
1-cyclopentyl-1-hydroxy-2-oxohydrazine
0.00017
1-cyclopentylidenethiosemicarbazide
Agaricus bisporus
-
-
0.00026 - 0.0022
1-dodecyl-1-hydroxy-2-oxohydrazine
0.00023
1-ethylidenethiosemicarbazide
Agaricus bisporus
-
-
0.77
1-hydroxy-1-methyl-3-(4-nitrophenyl)urea
Agaricus bisporus
-
-
0.0062 - 0.046
1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine
0.00013 - 0.0011
1-hydroxy-2-oxo-1-phenylhydrazine
0.041
1-hydroxy-3-(4-hydroxyphenyl)urea
Agaricus bisporus
-
-
0.032
1-hydroxy-3-(4-methoxyphenyl)urea
Agaricus bisporus
-
-
0.0026
1-hydroxy-3-(4-nitrophenyl)urea
Agaricus bisporus
-
-
0.00029
1-hydroxy-3-phenylurea
Agaricus bisporus
-
-
0.0043
1-hydroxy-3-[4-(trifluoromethyl)phenyl]urea
Agaricus bisporus
-
-
0.026
1-methoxy-3-naphthalen-2-ylthiourea
Agaricus bisporus
-
-
0.0803
1-methylethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.0078
1-pentanoyl-3-(2,3-dichlorophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0197
1-pentanoyl-3-(2,4,6-trimethylphenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0101
1-pentanoyl-3-(2,4-dinitrophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0195
1-pentanoyl-3-(2,6-dibromo-4-fluorophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0166
1-pentanoyl-3-(3-nitrophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0065
1-pentanoyl-3-(4-bromo-2-fluorophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0034
1-pentanoyl-3-(4-bromophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0023
1-pentanoyl-3-(4-chlorophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0016
1-pentanoyl-3-(4-methoxyphenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.008
1-pentanoyl-3-(4-nitrophenyl)thiourea
Agaricus bisporus
-
pH 6.8, 25°C
0.0002
1-propylidenethiosemicarbazide
Agaricus bisporus
-
-
0.000086
1-[1-(4-methoxyphenyl)ethylidene]thiosemicarbazide
Agaricus bisporus
-
-
0.0063
1-[4-(benzyloxy)phenyl]-3-hydroxyurea
Agaricus bisporus
-
-
0.07
1-[[tert-butyl(dimethyl)silyl]oxy]-3-phenylurea
Agaricus bisporus
-
-
0.068
1H-indol-5-ol
Mus musculus
-
-
0.582
2'-(3,4-dihydroxyphenyl)-3',5,5',7,7'-pentahydroxy-2-(4-hydroxyphenyl)-2,2',3,3',4a,8a-hexahydro-4H,4'H-3,8'-bichromene-4,4'-dione
Agaricus bisporus
-
-
0.0694
2,2':4',2''-ter-1,3,4-oxadiazole-5,5',5''(4H,4''H)-trithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.0029
2,2':4',2''-ter-1,3,4-thiadiazole-5,5',5''(4H,4''H)-trithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.0431 - 0.0461
2,3,4'-trihydroxy-4-methoxydeoxybenzoin
0.3 - 0.5
2,3,4,4'-tetrahydroxydeoxybenzoin
0.2033 - 0.3
2,3,4-trihydroxy-4'-methoxydeoxybenzoin
0.2613 - 0.3
2,4,4',6-tetrahydroxydeoxybenzoin
0.1359 - 0.1785
2,4,4'-trihydroxydeoxybenzoin
0.08435 - 0.1974
2,4,5-trihydroxy-4'-methoxydeoxybenzoin
0.07105 - 0.2302
2,4,6-trihydroxy-4'-methoxydeoxybenzoin
0.1121 - 0.2397
2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
0.0788 - 0.1814
2,4-dihydroxy-4'-methoxydeoxybenzoin
0.55
2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.550 mM
1.82
2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 1.820 mM
0.042
2,4-dihydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]benzamide
Mus musculus
-
-
0.00045
2-(2-furanylmethylene)-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.0265
2-(2-hydroxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.0591
2-(2-methoxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.16
2-(3,4-dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl 3,4,5-trihydroxybenzoate
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8) for 10 min at 25°C
0.12
2-(4-fluorophenyl)-quinazolin-4(3H)-one
Agaricus bisporus
-
pH and temperature not specified in the publication
0.0309
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate
Agaricus bisporus
-
pH 6.8, 25°C
0.0161
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate
Agaricus bisporus
-
pH 6.8, 25°C
0.0426
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 2,4-dihydroxybenzoate
Agaricus bisporus
-
pH 6.8, 25°C
0.1569
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 3,4-dihydroxybenzoate
Agaricus bisporus
-
pH 6.8, 25°C
0.0598
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 3,5-dihydroxybenzoate
Agaricus bisporus
-
pH 6.8, 25°C
0.2012
2-(4-formyl-2-methoxyphenoxy)-2-oxoethyl 4-hydroxybenzoate
Agaricus bisporus
-
pH 6.8, 25°C
0.00193
2-(phenylmethylene)-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00122 - 0.0154
2-chlorobenzaldehyde thiosemicarbazone
2.28
2-hydroxy-4-methoxybenzoic acid
Agaricus bisporus
-
-
1.65
2-hydroxy-4-methylbenzoic acid
Agaricus bisporus
-
-
7.9
2-hydroxy-5-methoxybenzoic acid
Agaricus bisporus
-
-
2.15
2-hydroxy-5-methylbenzoic acid
Agaricus bisporus
-
-
2.85
2-Hydroxybenzaldehyde
Agaricus bisporus
-
-
4.3
2-hydroxybenzoic acid
Agaricus bisporus
-
-
0.0749
2-hydroxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.0004
2-hydroxytropone
Agaricus bisporus
-
-
0.0981
2-methoxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
2.6
2-Methylbenzaldehyde
Agaricus bisporus
-
-
2.56
2-Methylbenzoic acid
Agaricus bisporus
-
-
0.717 - 1.415
2-Methylresorcinol
15
2-oxoglutaric acid
Agaricus bisporus
-
pH 7.0, 25°C
0.0153
2-[(1E,2E)-N-hydroxy-3-(pyridin-2-yl)prop-2-enimidoyl]phenol
Agaricus bisporus
-
pH 6.8, 30°C
0.0127
2-[(1E,2E)-N-hydroxy-3-(pyridin-3-yl)prop-2-enimidoyl]phenol
Agaricus bisporus
-
pH 6.8, 30°C
0.2
2-[(2,3,4-trihydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00018
2-[(2,4-dihydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.0065
2-[(2,5-dihydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.0875
2-[(2,5-dimethoxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00033
2-[(2-hydroxy-4-bromophenyl)methylene]thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00038
2-[(2-hydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.1152
2-[(3,4,5-trihydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.1455
2-[(3,4,5-trimethoxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.0422
2-[(3,4-dihydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.0336
2-[(3,5-dihydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00488
2-[(3-hydroxy-4-methoxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.0039
2-[(3-hydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00568
2-[(3-methoxy-4-hydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00028
2-[(4-bromophenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00041
2-[(4-hydroxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00148
2-[(4-methoxyphenyl)methylene]-thiosemicarbazone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.00073
2-[2-(2,4-dihydroxyphenyl)ethyl]-5-(D-xylopyranosyloxy)phenyl D-xylopyranoside
Agaricus bisporus
-
-
0.0016
2-[2-(2,4-dihydroxyphenyl)ethyl]-5-hydroxyphenyl D-xylopyranoside
Agaricus bisporus
-
5times more potent than that of kojic acid
0.0792
2-[2-(2-hydroxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.0676
2-[2-(2-methoxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.0000167
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(2,4-dihydroxyphenyl)prop-2-enoate
Agaricus bisporus
pH 6.8, 25°C
0.0067
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(4-chlorophenyl)prop-2-enoate
Agaricus bisporus
pH 6.8, 25°C
0.0065
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate
Agaricus bisporus
pH 6.8, 25°C
0.0077
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl (2E)-3-phenylprop-2-enoate
Agaricus bisporus
pH 6.8, 25°C
0.0067
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 2,4-dihydroxybenzoate
Agaricus bisporus
pH 6.8, 25°C
0.0652
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,4,5-trihydroxybenzoate
Agaricus bisporus
pH 6.8, 25°C
0.0159
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,4-dihydroxybenzoate
Agaricus bisporus
pH 6.8, 25°C
0.0938
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3,5-dihydroxybenzoate
Agaricus bisporus
pH 6.8, 25°C
0.0149
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 3-hydroxybenzoate
Agaricus bisporus
pH 6.8, 25°C
0.0149
2-[2-methyl-5-(propan-2-yl)phenoxy]-2-oxoethyl 4-hydroxybenzoate
Agaricus bisporus
pH 6.8, 25°C
0.001
2-[3-(2,4-dimethoxy-3-methylphenyl)propyl]benzene-1,4-diol
Agaricus bisporus
-
-
0.00112
2alpha,3alpha,23-trihydroxyolean-12-en-28-oic acid
Agaricus bisporus
-
-
0.0114
3'',4''-dihydroglabridin
Agaricus bisporus
-
in 20 mM phosphate buffer (pH 6.8), at 25°C
0.555
3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.555 mM
1.18
3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 1.180 mM
0.168 - 0.3
3,4-dihydroxy-4'-methoxydeoxybenzoin
0.28
3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.280 mM
2
3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 2.0 mM
0.073
3,4-dihydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]benzamide
Mus musculus
-
-
0.0003
3,4-dihydroxybenzaldehyde-O-ethyloxime
Agaricus bisporus
-
-
0.97
3,4-dihydroxycinnamic acid
Agaricus bisporus
-
-
1
3,4-dimethoxycinnamic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
1
3,4-dimethoxydihydrocinnamic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.705
3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.705 mM
0.71
3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide
Agaricus bisporus
-
IC50: 0.710 mM
0.55
3-(2-aminoethyl)-1H-indol-5-ol
Mus musculus
-
-
0.27
3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin
Agaricus bisporus
-
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C
3.68
3-(3-hydroxyphenyl)-2H-chromen-2-one
Agaricus bisporus
-
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C
0.016
3-hydroxy-1-methyl-1-phenylurea
Agaricus bisporus
-
-
3.7
3-Hydroxybenzaldehyde
Agaricus bisporus
-
-
1
3-hydroxycinnamic acid
Agaricus bisporus
-
IC50 above 1 mM
0.0006 - 0.0634
3-hydroxyphloretin
0.03
3-hydroxyphlorizin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
1.8
3-Methoxybenzaldehyde
Agaricus bisporus
-
-
0.45
3-methylbenzaldehyde
Agaricus bisporus
-
-
0.58
3-methylbenzoic acid
Agaricus bisporus
-
-
1.7
3-methylcrotonic acid
Agaricus bisporus
-
-
0.01102
3beta, 23, 24-trihydroxyolean-12-en-28-oic acid
Agaricus bisporus
-
-
0.1
4'-hydroxy-[1,1'-biphenyl]-2-carboxylic acid
Agaricus bisporus
-
pH 6.5, 30°C
0.01059
4'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
Agaricus bisporus
-
pH 6.5, 30°C
0.0147
4'-hydroxy-[1,1'-biphenyl]-4-carboxylic acid
Agaricus bisporus
-
pH 6.5, 30°C
0.1
4'-methoxy-[1,1'-biphenyl]-2-carboxylic acid
Agaricus bisporus
-
above, pH 6.5, 30°C
0.0153
4'-methoxy-[1,1'-biphenyl]-3-carboxylic acid
Agaricus bisporus
-
pH 6.5, 30°C
0.0153
4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid
Agaricus bisporus
-
pH 6.5, 30°C
0.0024
4,4'-diamino-3-(4-hydroxyphenyl)-1'H-1,3'-bi-1,2,4-triazole-5,5'(4H,4'H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00101
4,4'-diamino-3-(pyridin-4-yl)-1'H-1,3'-bi-1,2,4-triazole-5,5'(4H,4'H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00037
4,4'-ethane-1,2-diyldibenzene-1,3-diol
Agaricus bisporus
-
-
0.075
4-(1-methylethyl)benzaldehyde
Agaricus bisporus
-
-
0.225
4-(1-methylethyl)benzoic acid
Agaricus bisporus
-
-
0.049
4-(benzyloxy)-N'-(hydrazinylcarbonyl)benzohydrazide
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
1.15
4-(hexyloxy)benzoic acid
Agaricus bisporus
-
-
1.4
4-(pentyloxy)benzoic acid
Agaricus bisporus
-
-
0.215 - 4.13
4-Aminobenzoic acid
1.65
4-butoxybenzoic acid
Agaricus bisporus
-
-
0.038
4-butylbenzaldehyde
Agaricus bisporus
-
-
0.165 - 0.18
4-butylbenzoic acid
0.00182 - 0.0067
4-chlorobenzaldehyde thiosemicarbazone
0.1156
4-coumaric acid
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.00112
4-dodecylresorcinol
Pieris rapae
-
reversible and competitive inhibition, IC50: 0.00112 mM
0.023
4-ethenylbenzaldehyde
Agaricus bisporus
-
-
0.33
4-ethenylbenzoic acid
Agaricus bisporus
-
-
1.1
4-ethoxybenzoic acid
Agaricus bisporus
-
-
0.095
4-Ethylbenzaldehyde
Agaricus bisporus
-
-
0.29
4-ethylbenzoic acid
Agaricus bisporus
-
-
0.0019 - 0.00931
4-ethylresorcinol
0.0216
4-formyl-2-methoxyphenyl (4-methylpiperazin-1-yl)acetate
Agaricus bisporus
-
pH 6.8, 25°C
0.1014
4-formyl-2-methoxyphenyl (4-phenylpiperazin-1-yl)acetate
Agaricus bisporus
-
pH 6.8, 25°C
0.0789
4-formyl-2-methoxyphenyl chloroacetate
Agaricus bisporus
-
pH 6.8, 25°C
3
4-formylphenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
Agaricus bisporus
-
-
3
4-formylphenyl 2,3,4-tri-O-acetyl-beta-D-allopyranoside
Agaricus bisporus
-
-
3
4-formylphenyl 2,3,4-tri-O-benzyl-beta-D-ribopyranoside
Agaricus bisporus
-
-
3
4-formylphenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
Agaricus bisporus
-
-
0.62
4-formylphenyl 2,3-O-(1-methylethylidene)-beta-D-allopyranoside
Agaricus bisporus
-
-
0.052
4-formylphenyl 4,6-O-(phenylmethylidene)-beta-D-gulopyranoside
Agaricus bisporus
-
-
0.43
4-formylphenyl 6-O-(dimethoxyphosphoryl)-beta-D-allopyranoside
Agaricus bisporus
-
-
3
4-formylphenyl 6-O-trityl-beta-D-allopyranoside
Agaricus bisporus
-
-
2.54
4-formylphenyl beta-D-allopyranoside
Agaricus bisporus
-
-
0.94
4-formylphenyl beta-D-glucopyranoside
Agaricus bisporus
-
-
0.28
4-formylphenyl beta-D-ribopyranoside
Agaricus bisporus
-
-
2.54
4-formylphenyl-O-beta-D-allopyranoside
Agaricus bisporus
-
-
0.0088
4-heptylbenzaldehyde
Agaricus bisporus
-
-
0.075 - 0.095
4-heptylbenzoic acid
0.008
4-hexylbenzaldehyde
Agaricus bisporus
-
-
0.106 - 0.11
4-hexylbenzoic acid
0.0025 - 0.018
4-hexylresorcinol
0.97
4-hydroxy-3-methoxycinnamic acid
Agaricus bisporus
-
-
0.211
4-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-methoxybenzamide
Mus musculus
-
-
0.233
4-hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]benzamide
Mus musculus
-
-
1.12 - 1.22
4-hydroxybenzaldehyde
1.3
4-hydroxybenzoic acid
Agaricus bisporus
-
-
3
4-hydroxyphenyl beta-D-xyloside
Agaricus bisporus
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.74
4-hydroxyphenyl beta-xylodioside
Agaricus bisporus
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.18
4-hydroxyphenyl beta-xylotetraoside
Agaricus bisporus
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.48
4-hydroxyphenyl beta-xylotrioside
Agaricus bisporus
-
in 100 mM sodium phosphate buffer (pH 6.8), at 25°C
0.35
4-methoxybenzaldehyde
Agaricus bisporus
-
-
0.42
4-methoxybenzoic acid
Agaricus bisporus
-
-
0.41 - 0.8617
4-methoxycinnamic acid
0.12
4-methylbenzaldehyde
Agaricus bisporus
-
-
0.35
4-methylbenzoic acid
Agaricus bisporus
-
-
0.0011
4-methylresorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the diphenolase activity of mushroom tyrosinase
0.01
4-octylbenzaldehyde
Agaricus bisporus
-
-
0.047 - 0.082
4-octylbenzoic acid
0.0135
4-pentylbenzaldehyde
Agaricus bisporus
-
-
0.12 - 0.152
4-pentylbenzoic acid
0.8 - 1.1
4-phenyl-2-butanol
1.85
4-propoxybenzoic acid
Agaricus bisporus
-
-
0.075
4-propylbenzaldehyde
Agaricus bisporus
-
-
0.213 - 0.235
4-propylbenzoic acid
0.038
4-tert-butylbenzaldehyde
Agaricus bisporus
-
-
0.215
4-tert-butylbenzoic acid
Agaricus bisporus
-
-
0.00341
4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
Agaricus bisporus
-
-
0.00041
4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
Agaricus bisporus
-
-
0.00031
4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
Agaricus bisporus
-
-
0.0528
4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
Agaricus bisporus
-
-
0.0365
4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
Agaricus bisporus
-
-
0.00065
4-[(E)-(carbamothioylhydrazono)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
Agaricus bisporus
-
-
0.00361
4-[(E)-(carbamothioylhydrazono)methyl]phenyl beta-D-allopyranoside
Agaricus bisporus
-
-
0.00296
4-[(E)-(carbamothioylhydrazono)methyl]phenyl beta-D-glucopyranoside
Agaricus bisporus
-
-
0.2
4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(hydroxyimino)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(hydroxyimino)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(hydroxyimino)methyl]phenyl beta-D-allopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(hydroxyimino)methyl]phenyl beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-allopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl 2,3,4,6-tetrakis-O-(phenylcarbonyl)-beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl 2,3,4-tris-O-(phenylcarbonyl)-beta-D-xylopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl 2,3,6-tri-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl beta-D-allopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.2
4-[(E)-(methoxyimino)methyl]phenyl beta-D-glucopyranoside
Agaricus bisporus
-
IC50 above 0.2 mM
0.00043
4-[2-(2,4-dihydroxyphenyl)ethyl]-3-hydroxyphenyl D-xylopyranoside
Agaricus bisporus
-
-
0.024
4-[3-(2-hydroxy-5-methoxyphenyl)propyl]benzene-1,3-diol
Agaricus bisporus
-
-
0.0027 - 0.0238
4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol
0.0011 - 0.0137
4-[[hydroxy(nitroso)amino]methyl]phenol
0.0185
5'-(3-hydroxyphenyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00177
5'-(4-hydroxyphenyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00019
5'-(4-hydroxyphenyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00053
5'-(4-[[tert-butyl(dimethyl)silyl]oxy]phenyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00676
5'-(diphenylmethyl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.0052
5'-(diphenylmethyl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.0336
5'-(naphthalen-1-yl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.0142
5'-(pyridin-4-yl)-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00247
5'-(pyridin-4-yl)-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00367
5'-benzyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00494
5'-cyclohexyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00647
5'-phenyl-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00131
5'-phenyl-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00442
5'-[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00049
5'-[(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)methyl]-2,3'-bi-1,3,4-thiadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.0019
5'-[3-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00364
5'-[3-(benzyloxy)phenyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00135
5'-[4-(benzyloxy)phenyl]-2,3'-bi-1,3,4-oxadiazole-2',5(4H)-dithione
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.00026 - 0.01861
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
0.1325
5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)trione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.0342
5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.1374
5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.1793
5-(4-(2-butoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.1074
5-(4-(2-butoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.04545
5-(4-(2-butoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.1559
5-(4-(2-hydroxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(2-hydroxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(2-hydroxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(2-hydroxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.1128
5-(4-(2-methoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(2-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.02843
5-(4-(2-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.07542
5-(4-(2-methoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(4-methoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(4-methoxybutoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-(4-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.0778
5-(4-(4-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.07002
5-(4-hydroxybenzyl)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.2
5-(4-hydroxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.01449
5-(4-hydroxybenzylidene)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.01398
5-(4-hydroxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
0.0514 - 0.0516
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
0.98
5-hydroxymethyl-2-furfural
Agaricus bisporus
-
-
0.0422
6-hydroxy-2H-pyran-3-carbaldehyde
Agaricus bisporus
-
-
1.567
6-hydroxy-3-(4'-hydroxyphenyl)coumarin
Agaricus bisporus
-
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C
0.193
6-hydroxyapigenin
Agaricus bisporus
-
-
0.182
6-hydroxygalangin
Agaricus bisporus
-
-
0.124
6-hydroxykaempferol
Agaricus bisporus
-
-
0.1
7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-2-one
Agaricus bisporus
-
IC50 above 0.1 mM, in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C
0.0442 - 0.2
8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone
0.312
8-O-methyltianmushanol
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 37°C
0.2
9-hydroxy-4-methoxypsoralen
Agaricus bisporus
-
-
0.00078
Ac-KSRFR
Agaricus bisporus
-
pH 6.8, 25°C
0.00081
Ac-KSSFR
Agaricus bisporus
-
pH 6.8, 25°C
0.00075
Ac-RSRFK
Agaricus bisporus
-
pH 6.8, 25°C
0.00029
Ac-RSRFS
Agaricus bisporus
-
pH 6.8, 25°C
0.85
acetophenone
Agaricus bisporus
-
-
0.03
Agaritine
Agaricus bisporus
-
-
0.1
aloesin
Agaricus bisporus
-
-
12
alpha-picolyl heptyl amine
Agaricus bisporus
-
IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5)
12
alpha-picolyl pentyl amine
Agaricus bisporus
-
IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5)
12
alpha-picolyl propyl amine
Agaricus bisporus
-
IC50 above 12 mM, in 0.1 M phosphate buffer (pH 6.5)
0.0075 - 0.028
ammonium tetramolybdate
0.0001
anacardic acid
Agaricus bisporus
-
-
0.38
Anisaldehyde
Agaricus bisporus
-
-
0.68
Anisic acid
Agaricus bisporus
-
-
0.006577
arjungenin
Agaricus bisporus
-
-
0.001
arjunilic acid
Agaricus bisporus
-
-
0.001545
artocarpanone
Agaricus bisporus
-
-
0.0005254
artocarpesin
Agaricus bisporus
-
-
0.2009
artocarpetin
Agaricus bisporus
-
-
0.04793
artocarpfuranol
Agaricus bisporus
-
-
0.03 - 4.61
ascorbic acid
0.273
baicalein
Agaricus bisporus
-
-
0.0011
bayogenin
Agaricus bisporus
-
-
0.8
benzaldehyde
Agaricus bisporus
-
-
1.5 - 2
benzylideneacetone
6.3
beta-arbutin
Agaricus bisporus
-
-
0.49
beta-mercaptoethanol
Lactarius salmonicolor
-
at 25°C
9.5
beta-picolyl heptyl amine
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.5)
12
beta-picolyl pentyl amine
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.5)
12
beta-picolyl propyl amine
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.5)
1.44
betulin
Agaricus bisporus
-
-
0.00214
betulinic acid
Agaricus bisporus
-
-
25
Bromoacetate
Agaricus bisporus
-
-
0.06028
brosimone I
Agaricus bisporus
-
-
0.00043 - 0.00057
broussonin C
0.35
bufobutanoic acid
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0089
campestrol
Agaricus bisporus
-
isolated from Trifolium balansae, NMR structure identification, IC50: 0.00890 mM
0.09438
carpachromene
Agaricus bisporus
-
-
0.045
chrysin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
62.91
Citric acid
Lactuca sativa
-
-
0.1666
cudraflavone B
Agaricus bisporus
-
-
0.26
cumic acid
Agaricus bisporus
-
-
0.05
cuminaldehyde
Agaricus bisporus
-
-
0.06873
cyanomaclurin
Agaricus bisporus
-
-
0.0015
cyclohex-2-ene-1-carbonyl-CoA
Pieris rapae
-
reversible and competitive inhibition, IC50: 0.00150 mM
0.092
cyclomorusin
Agaricus bisporus
-
for monophenolase activity
0.58
D-ascorbic acid-6-p-hydroxybenzoic acid ester
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8) for 10 min at 25°C
0.194
daedalin A
Agaricus bisporus
-
-
1
dihydro-4-coumaric acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
1
dihydro-4-methoxycinnamic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
1
dihydrocaffeic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
1
dihydrocinnamic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
1
dihydroferulic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.1957
dihydroisoferulic acid
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.01035
dihydromorin
Agaricus bisporus
-
-
1
dihydrosinapic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
2350
DMSO
Sarcophaga bullata
-
at 30°C
26.4
EDTA
Lactuca sativa
-
-
0.0655
epigallocatechin gallate
Agaricus bisporus
-
-
0.00312
erythrodiol
Agaricus bisporus
-
-
0.0363
ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.11
farnesic acid
Agaricus bisporus
-
-
1
ferulic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.00179 - 0.00748
flemichin D
0.00101 - 0.0195
fleminchalcone A
0.0184 - 0.0326
fleminchalcone B
0.00128 - 0.00522
fleminchalcone C
6.8
gamma-picolyl heptyl amine
Agaricus bisporus
-
-
4.2
gamma-picolyl pentyl amine
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.5)
5.8
gamma-picolyl propyl amine
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.5)
1.62
geranial
Agaricus bisporus
-
-
0.01858
glabridin
Agaricus bisporus
-
in 20 mM phosphate buffer (pH 6.8), at 25°C
16.08
hesperidin
Agaricus bisporus
-
-
3.35 - 13.2
hexanoic acid
0.01348 - 1.09
hydroquinone
0.0006628
isoartocarpesin
Agaricus bisporus
-
-
0.1149
isoferulic acid
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0155 - 0.0228
kazinol C
0.00096 - 0.0017
kazinol F
0.0179 - 0.0269
kazinol S
3.6
KFEKKFEK
Agaricus bisporus
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C
0.00496 - 0.0204
khonklonginol H
0.88
kuraridinol
Agaricus bisporus
-
potent tyrosinase inhibitory activity
0.0022
kurarinone
Agaricus bisporus
-
-
0.135
kuwanon C
Agaricus bisporus
-
for monophenolase activity
0.0204 - 10.39
L-cysteine
3.56 - 16
L-phenylalanine
2.73
L-Pro-L-Leu-Gly
Agaricus bisporus
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C
0.00038
L-tyrosine
Lactarius salmonicolor
-
at 25°C
2.24
lupeol
Agaricus bisporus
-
-
0.0112 - 0.0841
lupinifolin
0.0017
maslinic acid
Agaricus bisporus
-
-
0.349
methyl (Z)-2-((E)-2-(((E)-(5-bromothiophen-2-yl)methylene)hydrazono)-4-oxothiazolidin-5-ylidene)acetate
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
0.101
methyl (Z)-2-((E)-2-(((E)-4-(dimethylamino)benzylidene)hydrazono)-4-oxothiazolidin-5-ylidene)acetate
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
0.002345
methyl arjunolate
Agaricus bisporus
-
-
0.0074 - 0.0646
moracin M
0.0825 - 0.2
moracinoside M
0.088
mormin
Agaricus bisporus
-
for monophenolase activity
0.25
morusin
Agaricus bisporus
-
for monophenolase activity
0.027
N',N'''-benzene-1,4-diylbis(1-hydroxyurea)
Agaricus bisporus
-
-
0.1772
N'-(hydrazinylcarbonyl)-4-hydroxybenzohydrazide
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.996
N'-(hydrazinylcarbonyl)naphthalene-2-carbohydrazide
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 25°C
0.17 - 0.23
N,N-unsubstituted selenourea derivatives
Agaricus bisporus
-
55.5% inhibition at 0.2 mM, IC50: 0.17-0.23 mM
-
0.029
N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.029 mM
0.017
N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide
Agaricus bisporus
-
IC50: 0.017 mM
0.011
N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.011 mM
0.0022
N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.0022 mM
1.66
N-benzyl-2,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 1.660 mM
0.78
N-benzyl-3,4,5-trihydroxybenzamide
Agaricus bisporus
-
IC50: 0.780 mM
2
N-benzyl-3,4-dihydroxybenzamide
Agaricus bisporus
-
IC50: 2.0 mM
0.7
N-benzyl-3,5-dihydroxybenzamide
Agaricus bisporus
-
IC50: 0.700 mM
1.99
N-benzylamide
Agaricus bisporus
-
IC50: 1.990 mM
0.028
N-caffeoylserotonin
Mus musculus
-
in 50 mM phosphate buffer (pH 6.8), at 37°C
0.17
N-hydroxy-N-(phenylcarbamoyl)acetamide
Agaricus bisporus
-
-
0.0018
N-phenylthiourea
Agaricus bisporus
-
-
0.073
N-protocatechuoylserotonin
Mus musculus
-
in 50 mM phosphate buffer (pH 6.8), at 37°C
0.311
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide
Mus musculus
-
-
0.333
N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]benzamide
Mus musculus
-
-
16.84
NaF
Litchi chinensis
-
-
0.1274 - 0.2
neocyclomorusin
1.49
nobiletin
Agaricus bisporus
-
-
0.0012 - 0.4647
norartocarpetin
2.15 - 3.06
octanoic acid
0.4
octyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.12
oxalic acid
Lactarius salmonicolor
-
at 25°C
0.001 - 0.0012
oxyresveratrol
0.23
p-aminobenzenesulfonamide
Lactarius salmonicolor
-
at 25°C
0.2 - 3.65
p-coumaric acid
4.54
p-hydroxybenzoic acid
Lactuca sativa
-
-
0.3506
p-hydroxybenzyl alcohol
Agaricus bisporus
-
-
0.00017 - 0.17
Phenylthiourea
0.0008
phloretin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity. Phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.087
phloridzin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.0025
pinosylvin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.346
procyanidin B1
Agaricus bisporus
-
-
0.042
protocatechuic acid
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.123
RADSRADC
Agaricus bisporus
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C
0.08
rutin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.0008 - 0.0012
Salicylhydroxamic acid
0.35
serotonin
Agaricus bisporus
-
IC50 above 0.35 mM, in 0.1 M phosphate buffer (pH 7.0), at 37°C
8
SFLLRN
Agaricus bisporus
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C
1
Sinapic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.06 - 41
Sodium metabisulfite
0.0047
sophoraflavanone G
Agaricus bisporus
-
-
1.13
soyacerebroside I
Agaricus bisporus
-
-
0.0005733 - 0.0265
steppogenin
0.00239
stigmast-5-ene-3beta,26-diol
Agaricus bisporus
-
isolated from Trifolium balansae, NMR structure identification, IC50: 0.00239 mM
0.00525
stigmast-5-ene-3beta-ol
Agaricus bisporus
-
isolated from Trifolium balansae, NMR structure identification, IC50: 0.00525 mM
0.4
syringic acid
Lactarius salmonicolor
-
at 25°C
0.358
tianmushanol
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 37°C
0.85
trans-cinnamaldehyde
Agaricus bisporus
-
-
0.14 - 2.3
trans-geranic acid
506.8
trifolirhizin
Agaricus bisporus
-
moderate inhibitory activity
0.42
umbelliferone
Agaricus bisporus
-
in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C
0.04
YRSRKYSSWY
Agaricus bisporus
-
in 0.67 mM potassium phosphate buffer (pH 6.8), at 37°C
0.00697
[1,1''-biphenyl]-3-carboxylic acid
Agaricus bisporus
-
pH 6.5, 30°C
0.1
[1,1'-biphenyl]-2-carboxylic acid
Agaricus bisporus
-
above, pH 6.5, 30°C
0.06324
[1,1'-biphenyl]-4-carboxylic acid
Agaricus bisporus
-
pH 6.5, 30°C
0.0753
[2-(furan-2-ylmethylene-hydrazono)-4-oxo-thiazolidin-5-ylidene]-acetic acid methyl ester
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
0.142
[2-[(4-benzyloxy-benzylidene)-hydrazono]-4-oxo-thiazolidin-5-ylidene]-acetic acid methyl ester
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
0.0032
[4-oxo-2-(pyridin-4-ylmethylene-hydrazono)-thiazolidin-5-ylidene]-acetic acid methyl ester
Agaricus bisporus
-
pH 6.8, 25°C, substrate L-DOPA
additional information
additional information
-
0.028
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
Mus musculus
-
-
0.2781
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]prop-2-enamide
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
12.05
(2E)-but-2-enoic acid
Agaricus bisporus
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
20
(2E)-but-2-enoic acid
Agaricus bisporus
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.008
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.216
(2E)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
Mus musculus
-
-
0.9
(2E,4E)-hexa-2,4-dienoic acid
Agaricus bisporus
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
4.95
(2E,4E)-hexa-2,4-dienoic acid
Agaricus bisporus
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.00024
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
Agaricus bisporus
-
-
0.012
1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)propane
Mus musculus
-
-
0.000086
1-(propan-2-ylidene)thiosemicarbazide
Agaricus bisporus
-
most potent inhibitor
0.00011
1-(propan-2-ylidene)thiosemicarbazide
Agaricus bisporus
-
-
0.000075
1-cyclopentyl-1-hydroxy-2-oxohydrazine
Agaricus bisporus
-
at pH 5.8
0.0006
1-cyclopentyl-1-hydroxy-2-oxohydrazine
Agaricus bisporus
-
at pH 6.8
0.00026
1-dodecyl-1-hydroxy-2-oxohydrazine
Agaricus bisporus
-
at pH 5.8
0.0022
1-dodecyl-1-hydroxy-2-oxohydrazine
Agaricus bisporus
-
at pH 6.8
0.0062
1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine
Agaricus bisporus
-
at pH 5.8
0.046
1-hydroxy-1-naphthalen-1-yl-2-oxohydrazine
Agaricus bisporus
-
-
0.00013
1-hydroxy-2-oxo-1-phenylhydrazine
Agaricus bisporus
-
at pH 5.8
0.0011
1-hydroxy-2-oxo-1-phenylhydrazine
Agaricus bisporus
-
at pH 6.8
0.0431
2,3,4'-trihydroxy-4-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.04337
2,3,4'-trihydroxy-4-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 0.5 h
0.0461
2,3,4'-trihydroxy-4-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.3
2,3,4,4'-tetrahydroxydeoxybenzoin
Agaricus bisporus
-
IC50 above 0.3 mM, at incubation interval of 0.5 h
0.3
2,3,4,4'-tetrahydroxydeoxybenzoin
Agaricus bisporus
-
IC50 above 0.3 mM, at incubation interval of 1.5 h
0.5
2,3,4,4'-tetrahydroxydeoxybenzoin
Agaricus bisporus
-
IC50 above 0.5 mM, at incubation interval of 2.5 h
0.2033
2,3,4-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.2119
2,3,4-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.3
2,3,4-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
IC50 above 0.3 mM, at incubation interval of 0.5 h
0.2613
2,4,4',6-tetrahydroxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.3
2,4,4',6-tetrahydroxydeoxybenzoin
Agaricus bisporus
-
IC50 above 0.3 mM, at incubation interval of 0.5 h
0.3
2,4,4',6-tetrahydroxydeoxybenzoin
Agaricus bisporus
-
IC50 above 0.3 mM, at incubation interval of 1.5 h
0.1359
2,4,4'-trihydroxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.1724
2,4,4'-trihydroxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.1785
2,4,4'-trihydroxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 0.5 h
0.08435
2,4,5-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 0.5 h
0.1442
2,4,5-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.1974
2,4,5-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.07105
2,4,6-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 0.5 h
0.2139
2,4,6-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.2302
2,4,6-trihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.1121
2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 0.5 h
0.2091
2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.2397
2,4-dihydroxy-3',4'-dimethoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.0788
2,4-dihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 0.5 h
0.1604
2,4-dihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.1814
2,4-dihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.00122
2-chlorobenzaldehyde thiosemicarbazone
Agaricus bisporus
-
using L-Dopa as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.0154
2-chlorobenzaldehyde thiosemicarbazone
Agaricus bisporus
-
using L-tyrosine as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.717
2-Methylresorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the diphenolase activity of mushroom tyrosinase
1.415
2-Methylresorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the monophenolase activity of mushroom tyrosinase
0.168
3,4-dihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 1.5 h
0.1777
3,4-dihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
at incubation interval of 2.5 h
0.3
3,4-dihydroxy-4'-methoxydeoxybenzoin
Agaricus bisporus
-
IC50 above 0.3 mM, at incubation interval of 0.5 h
0.035
3-cymene
Beta vulgaris
-
competitive, IC50: 0.035 mM
0.035
3-cymene
Homo sapiens
-
competitive, IC50: 0.035 mM
0.035
3-cymene
Neurospora crassa
-
competitive, IC50: 0.035 mM
0.035
3-cymene
Agaricus bisporus
-
competitive, IC50: 0.035 mM
0.035
3-cymene
Streptomyces glaucescens
-
competitive, IC50: 0.035 mM
0.0006
3-hydroxyphloretin
Homo sapiens
-
potent hydroxyl radical-scavenging, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.032
3-hydroxyphloretin
Homo sapiens
-
cellular tyrosinase-reducing activities, reduction of tyrosinase in HEMn cells
0.0634
3-hydroxyphloretin
Agaricus bisporus
-
exhibits a dose-dependent inhibitory effect on mushroom tyrosinase activity, enzyme kinetics study of 3-hydroxyphloretin as inhibitor with various concentrations of the L-tyrosine substrate (15.625, 31.25, 62.5, 125, 250, 500 microM)
0.215
4-Aminobenzoic acid
Lactuca sativa
-
using 4-methylcatechol as a substrate
1.52
4-Aminobenzoic acid
Lactuca sativa
-
using catechol as a substrate
4.13
4-Aminobenzoic acid
Lactuca sativa
-
using pyrogallol as a substrate
0.165
4-butylbenzoic acid
Agaricus bisporus
-
-
0.18
4-butylbenzoic acid
Solanum tuberosum
-
in 50 mM PBS (pH 6.8), temperature not specified in the publication
0.00182
4-chlorobenzaldehyde thiosemicarbazone
Agaricus bisporus
-
using L-Dopa as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.0067
4-chlorobenzaldehyde thiosemicarbazone
Agaricus bisporus
-
using L-tyrosine as substrate, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.0019
4-ethylresorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the monophenolase activity of mushroom tyrosinase
0.0033
4-ethylresorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the diphenolase activity of mushroom tyrosinase
0.00931
4-ethylresorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the monophenolase activity of mushroom tyrosinase
0.075
4-heptylbenzoic acid
Solanum tuberosum
-
in 50 mM PBS (pH 6.8), temperature not specified in the publication
0.095
4-heptylbenzoic acid
Agaricus bisporus
-
-
0.106
4-hexylbenzoic acid
Solanum tuberosum
-
in 50 mM PBS (pH 6.8), temperature not specified in the publication
0.11
4-hexylbenzoic acid
Agaricus bisporus
-
-
0.0025
4-hexylresorcinol
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, partially purified)
0.018
4-hexylresorcinol
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, crude powder, lot 105k7026)
1.12
4-hydroxybenzaldehyde
Agaricus bisporus
-
-
1.15
4-hydroxybenzaldehyde
Agaricus bisporus
-
-
1.22
4-hydroxybenzaldehyde
Agaricus bisporus
-
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C
1.22
4-hydroxybenzaldehyde
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.41
4-methoxycinnamic acid
Agaricus bisporus
-
-
0.41
4-methoxycinnamic acid
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.8617
4-methoxycinnamic acid
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.047
4-octylbenzoic acid
Solanum tuberosum
-
in 50 mM PBS (pH 6.8), temperature not specified in the publication
0.082
4-octylbenzoic acid
Agaricus bisporus
-
-
0.12
4-pentylbenzoic acid
Agaricus bisporus
-
-
0.152
4-pentylbenzoic acid
Solanum tuberosum
-
in 50 mM PBS (pH 6.8), temperature not specified in the publication
0.8
4-phenyl-2-butanol
Agaricus bisporus
-
inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication
1.1
4-phenyl-2-butanol
Agaricus bisporus
-
inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication
0.213
4-propylbenzoic acid
Solanum tuberosum
-
in 50 mM PBS (pH 6.8), temperature not specified in the publication
0.235
4-propylbenzoic acid
Agaricus bisporus
-
-
0.0027
4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol
Agaricus bisporus
-
at pH 5.8
0.0238
4-[[hydroxy(nitroso)amino]methyl]benzene-1,3-diol
Agaricus bisporus
-
at pH 6.8
0.0011
4-[[hydroxy(nitroso)amino]methyl]phenol
Agaricus bisporus
-
at pH 5.8
0.0137
4-[[hydroxy(nitroso)amino]methyl]phenol
Agaricus bisporus
-
at pH 6.8
0.00026
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
Agaricus bisporus
-
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.01861
5,2',4'-trihydroxy-2'',2''-dimethylchromene-(6,7:5'',6'')-flavanone
Agaricus bisporus
-
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.0514
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0516
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0442
8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0985
albafuran A
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
albafuran A
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0075
ammonium tetramolybdate
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, partially purified)
0.028
ammonium tetramolybdate
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, crude powder, lot 105k7026)
0.04
arbutin
Agaricus bisporus
-
-
0.201
arbutin
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.2105
arbutin
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.3292
arbutin
Agaricus bisporus
-
-
0.672
arbutin
Agaricus bisporus
-
daedalin A is 3times more potent than arbutin
1.43
arbutin
Homo sapiens
-
-
3
arbutin
Homo sapiens
-
-
7.3
arbutin
Agaricus bisporus
-
-
8.4
arbutin
Agaricus bisporus
-
-
10.4
arbutin
Agaricus bisporus
-
-
27.31
arbutin
Agaricus bisporus
-
-
548
arbutin
Agaricus bisporus
-
-
0.03
ascorbic acid
Macrolepiota gracilenta
-
monophenolase activity, at pH 7.0 and 40°C
0.0426
ascorbic acid
Anethum graveolens
-
-
0.0672
ascorbic acid
Lactuca sativa
-
using pyrogallol as a substrate
0.08
ascorbic acid
Mespilus germanica
-
at ripening stage 3
0.08
ascorbic acid
Neoboletus erythropus
-
pH 8.0, 20°C
0.09
ascorbic acid
Mespilus germanica
-
at ripening stage 1
0.1
ascorbic acid
Mespilus germanica
-
at ripening stage 2
0.22
ascorbic acid
Lactuca sativa
-
using catechol as a substrate
0.221
ascorbic acid
Lactuca sativa
-
using 4-methylcatechol as a substrate
0.26
ascorbic acid
Macrolepiota gracilenta
-
diphenolase activity, at pH 5.0 and 30°C
4.61
ascorbic acid
Lactuca sativa
-
-
0.9
benzoic acid
Macrolepiota gracilenta
-
monophenolase activity, at pH 7.0 and 40°C
1
benzoic acid
Agaricus bisporus
-
-
4.33
benzoic acid
Macrolepiota gracilenta
-
diphenolase activity, at pH 5.0 and 30°C
10.2
benzoic acid
Neoboletus erythropus
-
pH 8.0, 20°C
0.6
benzylacetone
Agaricus bisporus
-
inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication
2.8
benzylacetone
Agaricus bisporus
-
inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication
1.5
benzylideneacetone
Agaricus bisporus
-
inhibition of monophenolase activity of the enzyme, pH and temperature not specified in the publication
2
benzylideneacetone
Agaricus bisporus
-
inhibition of diphenolase activity of the enzyme, pH and temperature not specified in the publication
0.00043
broussonin C
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.00057
broussonin C
Agaricus bisporus
-
using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.4
caffeic acid
Agaricus bisporus
-
-
1
caffeic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0011
catechol
Homo sapiens
-
potent hydroxyl radical-scavenging, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.022
catechol
Homo sapiens
-
cellular tyrosinase-reducing activities, reduction of tyrosinase in HEMn cells
0.02
cefazolin
Agaricus bisporus
-
for diphenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
7
cefazolin
Agaricus bisporus
-
for monophenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.13
cefodizime
Agaricus bisporus
-
for monophenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.21
cefodizime
Agaricus bisporus
-
for diphenolase activity of tyrosinase, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
1
Cinnamic acid
Agaricus bisporus
-
IC50 above 1 mM
1
Cinnamic acid
Agaricus bisporus
-
IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C
155
Cl-
Homo sapiens
-
human tyrosinase source TXM13 pigment cell
164
Cl-
Homo sapiens
-
human tyrosinase source HEK293-TYR
0.017
davanol
Beta vulgaris
-
competitive, IC50: 0.017 mM
0.017
davanol
Homo sapiens
-
competitive, IC50: 0.017 mM
0.017
davanol
Neurospora crassa
-
competitive, IC50: 0.017 mM
0.017
davanol
Agaricus bisporus
-
competitive, IC50: 0.017 mM
0.017
davanol
Streptomyces glaucescens
-
competitive, IC50: 0.017 mM
0.034
dillapiole
Beta vulgaris
-
competitive, IC50: 0.034 mM
0.034
dillapiole
Homo sapiens
-
competitive, IC50: 0.034 mM
0.034
dillapiole
Neurospora crassa
-
competitive, IC50: 0.034 mM
0.034
dillapiole
Agaricus bisporus
-
competitive, IC50: 0.034 mM
0.034
dillapiole
Streptomyces glaucescens
-
competitive, IC50: 0.034 mM
0.21
esculetin
Agaricus bisporus
Worthington mushroom tyrosinase (WMT, crude powder, lot 33H6588Q)
0.225
esculetin
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, crude powder, lot 105k7026)
0.00179
flemichin D
Agaricus bisporus
-
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.00748
flemichin D
Agaricus bisporus
-
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.00101
fleminchalcone A
Agaricus bisporus
-
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.0195
fleminchalcone A
Agaricus bisporus
-
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.0184
fleminchalcone B
Agaricus bisporus
-
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.0326
fleminchalcone B
Agaricus bisporus
-
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.00128
fleminchalcone C
Agaricus bisporus
-
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.00522
fleminchalcone C
Agaricus bisporus
-
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.0114
glutathione
Lactuca sativa
-
using pyrogallol as a substrate
0.0167
glutathione
Lactuca sativa
-
using 4-methylcatechol as a substrate
0.0325
glutathione
Anethum graveolens
-
-
0.0662
glutathione
Lactuca sativa
-
using catechol as a substrate
0.19
glutathione
Litchi chinensis
-
-
0.91
glutathione
Lactarius salmonicolor
-
at 25°C
4.7
glutathione
Lactuca sativa
-
-
3.35
hexanoic acid
Agaricus bisporus
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
13.2
hexanoic acid
Agaricus bisporus
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.01348
hydroquinone
Agaricus bisporus
-
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.037
hydroquinone
Agaricus bisporus
-
-
0.0916
hydroquinone
Agaricus bisporus
-
-
1.09
hydroquinone
Agaricus bisporus
-
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.23
kaempferol
Agaricus bisporus
-
-
0.23
kaempferol
Neurospora crassa
-
competitive, IC50: 0.230 mM
0.23
kaempferol
Agaricus bisporus
-
competitive, IC50: 0.230 mM
0.23
kaempferol
Streptomyces glaucescens
-
competitive, IC50: 0.230 mM
0.262
kaempferol
Agaricus bisporus
-
-
0.0155
kazinol C
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0228
kazinol C
Agaricus bisporus
-
using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.1647
kazinol D
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
kazinol D
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.00096
kazinol F
Agaricus bisporus
-
using L-tyrosine as substrate, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0017
kazinol F
Agaricus bisporus
-
using L-DOPA as substrate, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0179
kazinol S
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0269
kazinol S
Agaricus bisporus
-
using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.1031
kazinol T
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
kazinol T
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.00496
khonklonginol H
Agaricus bisporus
-
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.0204
khonklonginol H
Agaricus bisporus
-
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.0074
kojic acid
Agaricus bisporus
-
-
0.008
kojic acid
Agaricus bisporus
-
-
0.0123
kojic acid
Agaricus bisporus
-
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.01476
kojic acid
Agaricus bisporus
-
in 20 mM phosphate buffer (pH 6.8), at 25°C
0.0163
kojic acid
Agaricus bisporus
-
IC50: 0.0163 mM
0.0163
kojic acid
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.01667
kojic acid
Agaricus bisporus
-
-
0.01667
kojic acid
Agaricus bisporus
-
IC50: 0.01667 mM
0.01857
kojic acid
Agaricus bisporus
-
value for inhibition of monophenolase activity using L-Dopa as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.025
kojic acid
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, partially purified)
0.03
kojic acid
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, crude powder, lot 105k7026)
0.0372
kojic acid
Agaricus bisporus
-
-
0.0373
kojic acid
Agaricus bisporus
-
pH 6.8, 30°C
0.0373
kojic acid
Agaricus bisporus
-
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.045
kojic acid
Agaricus bisporus
Worthington mushroom tyrosinase (WMT, crude powder, lot 33H6588Q)
0.048
kojic acid
Illex argentinus
IC50: 0.048 mM for ST94 and ST94t
0.061
kojic acid
Mus musculus
-
in 50 mM phosphate buffer (pH 6.8), at 37°C
0.06655
kojic acid
Agaricus bisporus
-
-
0.0716
kojic acid
Agaricus bisporus
-
-
0.075
kojic acid
Agaricus bisporus
-
-
0.0752
kojic acid
Agaricus bisporus
-
-
0.129
kojic acid
Agaricus bisporus
-
value for inhibition of diphenolase activity using L-tyrosine as substrate, in 50 mM phosphate buffer, pH 6.5, at 37°C
0.13
kojic acid
Agaricus bisporus
-
-
0.1328
kojic acid
Agaricus bisporus
-
at incubation interval of 0.5 h
0.22
kojic acid
Crocus sativus
-
with catechol as substrate, competitive inhibition
0.2251
kojic acid
Agaricus bisporus
-
at incubation interval of 1.5 h
0.243
kojic acid
Agaricus bisporus
-
in 50 mM Na-phosphate buffer (pH 6.8), at 37°C
0.273
kojic acid
Mus musculus
-
-
0.277
kojic acid
Agaricus bisporus
-
IC50: 0.277 mM
0.323
kojic acid
Agaricus bisporus
-
in 0.1 M phosphate buffer (pH 6.8), at 37°C
0.35
kojic acid
Crocus sativus
-
with pyrogallol as substrate, mixed inhibition
0.3881
kojic acid
Agaricus bisporus
-
-
0.4383
kojic acid
Agaricus bisporus
-
at incubation interval of 2.5 h
0.5
kojic acid
Crocus sativus
-
with p-cresol as substrate, uncompetitive inhibition
0.68
kojic acid
Agaricus bisporus
-
-
0.7
kojic acid
Crocus sativus
-
with L-dopa as substrate, noncompetitive inhibition
0.0001
kurarinol
Agaricus bisporus
-
-
8.6
kurarinol
Agaricus bisporus
-
potent tyrosinase inhibitory activity
0.1318
kuwanon A
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
kuwanon A
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0475
kuwanon E
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
kuwanon E
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
kuwanon U
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
kuwanon U
Agaricus bisporus
-
IC50 above 0.2 mM, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0204
L-cysteine
Anethum graveolens
-
-
0.13
L-cysteine
Litchi chinensis
-
-
0.15
L-cysteine
Lactarius salmonicolor
-
at 25°C
0.24
L-cysteine
Macrolepiota gracilenta
-
diphenolase activity, at pH 5.0 and 30°C
0.3
L-cysteine
Macrolepiota gracilenta
-
monophenolase activity, at pH 7.0 and 40°C
10.39
L-cysteine
Lactuca sativa
-
-
0.00368
L-mimosine
Agaricus bisporus
-
-
0.00368
L-mimosine
Agaricus bisporus
-
IC50: 0.00368 mM
3.56
L-phenylalanine
Macrolepiota gracilenta
-
diphenolase activity, at pH 5.0 and 30°C
16
L-phenylalanine
Macrolepiota gracilenta
-
monophenolase activity, at pH 7.0 and 40°C
0.0112
lupinifolin
Agaricus bisporus
-
with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.0841
lupinifolin
Agaricus bisporus
-
with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C
0.04
Methimazole
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, crude powder, lot 105k7026)
0.047
Methimazole
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, partially purified)
0.0074
moracin M
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0646
moracin M
Agaricus bisporus
-
using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.1603
moracin N
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
moracin N
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0825
moracinoside M
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
moracinoside M
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
2.32
morin
Beta vulgaris
-
competitive, IC50: 2.320 mM
2.32
morin
Homo sapiens
-
competitive, IC50: 2.320 mM
2.32
morin
Neurospora crassa
-
competitive, IC50: 2.320 mM
2.32
morin
Agaricus bisporus
-
competitive, IC50: 2.320 mM
2.32
morin
Streptomyces glaucescens
-
competitive, IC50: 2.320 mM
0.2
morusinol
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
morusinol
Agaricus bisporus
-
IC50 above 0.2 mM, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.1274
neocyclomorusin
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
neocyclomorusin
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0012
norartocarpetin
Agaricus bisporus
-
for monophenolase activity
0.0012
norartocarpetin
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.2
norartocarpetin
Agaricus bisporus
-
IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.4647
norartocarpetin
Agaricus bisporus
-
-
2.15
octanoic acid
Agaricus bisporus
-
value for inhibition of diphenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
3.06
octanoic acid
Agaricus bisporus
-
value for inhibition of monophenolase activity, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 30°C
0.001
oxyresveratrol
Agaricus bisporus
-
-
0.0012
oxyresveratrol
Agaricus bisporus
-
pH 7.0, 25°C
0.2
p-coumaric acid
Agaricus bisporus
-
-
3.65
p-coumaric acid
Agaricus bisporus
-
-
0.00017
Phenylthiourea
Illex argentinus
IC50: 0.00017 mM for ST94, 0.00018 mM for ST94t
0.17
Phenylthiourea
Agaricus bisporus
-
IC50: 0.17 mM
0.0012
quercetin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.07
quercetin
Beta vulgaris
-
competitive, IC50: 0.070 mM
0.07
quercetin
Homo sapiens
-
competitive, IC50: 0.070 mM
0.07
quercetin
Neurospora crassa
-
competitive, IC50: 0.070 mM
0.07
quercetin
Agaricus bisporus
-
competitive, IC50: 0.070 mM
0.07
quercetin
Streptomyces glaucescens
-
competitive, IC50: 0.070 mM
0.652
resorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the diphenolase activity of mushroom tyrosinase
1.125
resorcinol
Agaricus bisporus
-
pH 7.0, 25°C, inhibition of the monophenolase activity of mushroom tyrosinase
0.0008
Salicylhydroxamic acid
Agaricus bisporus
Worthington mushroom tyrosinase (WMT, crude powder, lot 33H6588Q)
0.0009
Salicylhydroxamic acid
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, partially purified)
0.0012
Salicylhydroxamic acid
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, crude powder, lot 105k7026)
0.05
Sodium azide
Mespilus germanica
-
at ripening stage 3
0.06
Sodium azide
Mespilus germanica
-
at ripening stage 1
0.06
Sodium azide
Mespilus germanica
-
at ripening stage 2
0.5
Sodium azide
Macrolepiota gracilenta
-
monophenolase activity, at pH 7.0 and 40°C
10
Sodium azide
Neoboletus erythropus
-
pH 8.0, 20°C
13.8
Sodium azide
Macrolepiota gracilenta
-
diphenolase activity, at pH 5.0 and 30°C
0.06
Sodium metabisulfite
Macrolepiota gracilenta
-
monophenolase activity, at pH 7.0 and 40°C
0.07
Sodium metabisulfite
Neoboletus erythropus
-
pH 8.0, 20°C
0.178
Sodium metabisulfite
Macrolepiota gracilenta
-
diphenolase activity, at pH 5.0 and 30°C
9
Sodium metabisulfite
Mespilus germanica
-
at ripening stage 3
23.8
Sodium metabisulfite
Mespilus germanica
-
at ripening stage 1
41
Sodium metabisulfite
Mespilus germanica
-
at ripening stage 2
0.0005733
steppogenin
Agaricus bisporus
-
-
0.0013
steppogenin
Agaricus bisporus
-
using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
0.0265
steppogenin
Agaricus bisporus
-
using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C
2
Thiosemicarbazide
Agaricus bisporus
-
-
2
Thiosemicarbazide
Agaricus bisporus
-
IC50 aboe 2.0 mM, in 50 mM phosphate buffer (pH 6.8), at 25°C
0.008
Thiourea
Macrolepiota gracilenta
-
monophenolase activity, at pH 7.0 and 40°C
0.085
Thiourea
Macrolepiota gracilenta
-
diphenolase activity, at pH 5.0 and 30°C
1.49
Thiourea
Mespilus germanica
-
at ripening stage 3
1.5
Thiourea
Mespilus germanica
-
at ripening stage 1
1.73
Thiourea
Mespilus germanica
-
at ripening stage 2
0.14
trans-geranic acid
Agaricus bisporus
-
isomer 1
2.3
trans-geranic acid
Agaricus bisporus
-
isomer 2
0.0004
tropolone
Agaricus bisporus
-
-
0.00042
tropolone
Agaricus bisporus
-
in 50 mM phosphate buffer (pH 6.8), at 25°C
0.0013
tropolone
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, crude powder, lot 105k7026)
0.0017
tropolone
Agaricus bisporus
Sigma mushroom tyrosinase (SMT, partially purified)
0.0021
tropolone
Illex argentinus
IC50: 0.0021 mM for ST94, 0.0022 mM for ST94t
0.011
tropolone
Lactuca sativa
-
using pyrogallol as a substrate
0.013
tropolone
Lactuca sativa
-
using catechol as a substrate
0.413
tropolone
Lactuca sativa
-
using 4-methylcatechol as a substrate
additional information
additional information
Agaricus bisporus
-
1-hydroxy-2-oxo-1-phenylhydrazine displays competitive inhibition at pH 6.8 and 5.8, all the other N-substituted N-nitrosohydroxylamines show a different type of inhibition at pH 6.8. and 5.8
-
additional information
additional information
Agaricus bisporus
-
daedalin A also shows 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC50: 16.9 microM) and superoxide anion scavenging activity (IC50: 28.5 microM)
-
additional information
additional information
Agaricus bisporus
-
Ganoderma lucidum exhibits significant inhibition of tyrosinase activity, IC50 value 0.32 mg/ml
-
additional information
additional information
Agaricus bisporus
-
IC50 values for N-phenylurea, 1-(2,4-dimethoxyphenyl)-3-hydroxyurea, 1-(4-butoxyphenyl)-3-hydroxyurea, 3-(4-bromophenyl)-1-hydroxy-1-methylurea, 1-methoxy-3-phenylurea, 1-hydroxy-1-methyl-3-phenylurea, 1-hydroxy-1,3-dimethyl-3-phenylurea, 3-methoxy-1-methyl-1-phenylurea, 1-hydroxy-3-phenylthiourea, 1-methoxy-3-(4-nitrophenyl)thiourea are above 1 mM
-
additional information
additional information
Agaricus bisporus
-
IC50-value for petroleum ether: 8.09 mg/ml, IC50-value for crude ethanol phase (ECPE): 7.53 mg/ml, IC50-value for macroporus adsorption resin (FGRE): 4.80 mg/ml
-
additional information
additional information
Agaricus bisporus
-
IC50-values above 1 mM for artocarpin, cycloartocarpin, and cycloartocarpesin
-
additional information
additional information
Agaricus bisporus
-
methanolic and acetonic extracts of the stem bark of Sideroxylon inerme show significant inhibition of monophenolase activity (IC50 values of 63 microg/ml and 82 microg/ml). The methanolic extract also exhibits 37% reduction of melanin content at 6.2 microg/ml in melanocytes without being significantly toxic to the cells
-