1.14.17.3: peptidylglycine monooxygenase
This is an abbreviated version!
For detailed information about peptidylglycine monooxygenase, go to the full flat file.
Word Map on EC 1.14.17.3
-
1.14.17.3
-
glycine-extended
-
neuropeptides
-
beta-monooxygenase
-
peptidyl-alpha-hydroxyglycine
-
prohormone
-
alpha-hydroxyglycine
-
peptidylamidoglycolate
-
endoproteolytic
-
neurointermediate
-
corticotrope
-
ascorbate-dependent
-
exafs
-
4.3.2.5
-
4-phenyl-3-butenoic
-
noncoupled
-
side-on
-
dbetam
-
medicine
-
analysis
-
synthesis
-
pharmacology
- 1.14.17.3
-
glycine-extended
- neuropeptides
-
beta-monooxygenase
-
peptidyl-alpha-hydroxyglycine
-
prohormone
- alpha-hydroxyglycine
- peptidylamidoglycolate
-
endoproteolytic
-
neurointermediate
-
corticotrope
-
ascorbate-dependent
-
exafs
-
4.3.2.5
-
4-phenyl-3-butenoic
-
noncoupled
-
side-on
- dbetam
- medicine
- analysis
- synthesis
- pharmacology
Reaction
Synonyms
alpha-AE, bifunctional PAM, bifunctional peptidylglycine alpha-amidating monooxygenase, CG3832, hPHMcc, More, PAM, PAM-1, PAM-2, PAM-A, PAM-B, PAM/PHM, peptide alpha-amidating enzyme, peptide alpha-amide synthase, peptide-alpha-amide synthetase, peptidyl alpha-amidating enzyme, peptidyl alpha-hydroxylating monooxygenase, peptidyl-glycine alpha-amidating monooxygenase, peptidylglycine 2-hydroxylase, peptidylglycine alpha-amidating mono-oxygenase, peptidylglycine alpha-amidating monooxygenase, peptidylglycine alpha-hydroxylase, peptidylglycine alpha-hydroxylating monooxygenase, peptidylglycine alpha-hydroxylating-monooxygenase, peptidylglycine alpha-monooxygenase, peptidylglycine monooxygenase, peptidylglycine-alpha-amidating monooxygenase, PHM, PHMcc, synthase, peptide alpha-amide, type A PAM
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Reference on EC 1.14.17.3 - peptidylglycine monooxygenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Glembotski, C.C.
Further characterization of the peptidyl alpha-amidating enzyme in rat anterior pituitary secretory granules
Arch. Biochem. Biophys.
241
673-683
1985
Rattus norvegicus
Bradbury, A.F.; Smyth, D.G.
Enzyme-catalysed peptide amidation. Isolation of a stable intermediate formed by reaction of the amidating enzyme with an imino acid
Eur. J. Biochem.
169
579-584
1987
Sus scrofa
Bradbury, A.F.; Finnie, M.D.A.; Smyth, D.G.
Mechanism of C-terminal amide formation by pituitary enzymes
Nature
298
686-689
1982
Sus scrofa
Gale, J.S.; McIntosh, J.E.A.; McIntosh, R.P.
Peptidyl-glycine alpha-amidating mono-oxygenase activity towards a gonadotropin-releasing-hormone C-terminal peptide substrate, in subcellular fractions of sheep brain and pituitary
Biochem. J.
251
251-259
1988
Ovis aries
Beaudry, G.A.; Mehta, N.M.; Ray, M.I.; Bertelsen, A.H.
Purification and characterization of functional recombinant alpha-amidating enzyme secreted from mammalian cells
J. Biol. Chem.
265
17694-17699
1990
Rattus norvegicus
Perkins, S.N.; Husten, E.J.; Eipper, B.A.
The 108-kDA peptidylglycine alpha-amidating monooxygenase precursor contains two separable enzymatic activities involved in peptide amidation
Biochem. Biophys. Res. Commun.
171
926-932
1990
Bos taurus
Katapodis, A.G.; May, S.W.
A new facile trinitrophenylated substrate for peptide alpha-amidation and its use to characterize PAM activity in chromaffin granules
Biochem. Biophys. Res. Commun.
151
499-505
1988
Bos taurus
Suzuki, K.; Shimoi, H.; Iwasaki, Y.; Kawahara, T.; Matsuura, Y.; Nishikawa, Y.
Elucidation of amidating reaction mechanism by frog amidating enzyme, peptidylglycine alpha-hydroxylating monooxygenase, expressed in insect cell culture
EMBO J.
9
4259-4265
1990
Xenopus laevis
Murthy, A.S.N.; Mains, R.E.; Eipper, B.A.
Purification and characterization of peptidylglycine alpha-amidating monooxygenase from bovine neurointermediate pituitary
J. Biol. Chem.
261
1815-1822
1986
Bos taurus
Merkler, D.J.; Young, S.D.
Recombinant type A rat 75-kDa alpha-amidating enzyme catalyzes the conversion of glycine-extended peptides to peptide amides via an alpha-hydroxyglycine intermediate
Arch. Biochem. Biophys.
289
192-196
1991
Rattus norvegicus
Glembotski, C.C.; Eipper, B.A.; Mains, R.E.
Characterization of a peptide alpha-amidation activity from rat anterior pituitary
J. Biol. Chem.
259
6385-6392
1984
Rattus norvegicus
Mizuno, K.; Sakata, J.; Kojima, M.; Kangawa, K.; Matsuo, H.
Peptide C-terminal alpha-amidating enzyme purified to homogeneity from Xenopus laevis skin
Biochem. Biophys. Res. Commun.
137
984-991
1986
Xenopus laevis
Mehta, N.M.; Gilligan, J.P.; Jones, B.N.; Bertelsen, A.H.; Roos, B.A.; Birnbaum, R.S.
Purification of a peptidylglycine alpha-amidating enzyme from transplantable rat medullary thyroid carcinomas
Arch. Biochem. Biophys.
261
44-54
1988
Rattus norvegicus
Bradbury, A.F.; Smyth, D.G.
C-Terminal amide formation in peptide hormones
Biogenetics of Neurohormonal Peptides (Hakanson, R. , Thorell, J. , eds) Academic Press
London
171-186
1985
Bos taurus
-
Bendig, M.M.
Post-translational processing in Xenopus oocytes includes carboxyl-terminal amidation
J. Biol. Chem.
261
11935-11937
1986
Xenopus laevis
Sakata, J.; Mizuno, J.; Matsuo, H.
Tissue distribution and characterization of peptide C-terminal alpha-amidating activity in rat
Biochem. Biophys. Res. Commun.
140
230-236
1986
Sus scrofa
Katapodis, A.G.; May, S.W.
Novel substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase
Biochemistry
29
4541-4548
1990
Bos taurus
Kojima, M.; Mizuno, K.; Kangawa, K.; Matsuo, H.
Purification and characterization of a peptide C-terminal alpha-amidating enzyme from porcine atrium
J. Biochem.
105
440-443
1989
Sus scrofa
Tajima, M.; Iida, T.; Yoshida, S.; Komatsu, K.; Namba, R.; Yanagi, M.; Noguchi, M.; Okamoto, H.
The reaction product of peptidylglycine alpha-amidating enzyme is a hydroxyl derivative at alpha-carbon of the carboxyl-terminal glycine
J. Biol. Chem.
265
9602-9605
1990
Equus caballus
Scopsi, L.; Lee, R.; Gullo, M.; Collini, P.; Husten, E.J.; Eipper, B.A.
Peptidylglycine alpha-amidating monooxygenase in neuroendocrine tumors: its identification, characterization, quantification, and relation to the grade of morphologic differentiation, amidated peptide content, and granin immunocytochemistry
Appl. Immunohistochem.
6
120-132
1998
Homo sapiens
-
Chikuma, T.; Kocha, T.; Hanaoka, K.; Kato, T.; Ishii, Y.; Tanaka, A.
Characterization of peptidylglycine alpha-amidating monooxygenase in bovine hypothalamus
Neurochem. Int.
25
349-354
1994
Bos taurus
Iwasaki, Y.; Shimoi, H.; Saiki, H.; Nishikawa, Y.
Tissue-specific molecular diversity of amidating enzymes (peptidylglycine alpha-hydroxylating monooxygenase and peptidylhydroxyglycine N-C lyase) in Xenopus laevis
Eur. J. Biochem.
214
811-818
1993
Xenopus laevis
Suzuki, K.; Ohta, M.; Okamoto, M.; Nishikawa, Y.
Functional expression and characterization of a Xenopus laevis peptidylglycine alpha-amidating monooxygenase, AE-II, in insect-cell culture
Eur. J. Biochem.
213
93-98
1993
Xenopus laevis
Shimoi, H.; Kawahara, T.; Suzuki, K.; Iwasaki, Y.; Jeng, A.Y.; Nishikawa, Y.
Characterization of a Xenopus laevis skin peptidylglycine alpha-hydroxylating monooxygenase expressed in insect-cell culture
Eur. J. Biochem.
209
189-194
1992
Xenopus laevis
Boudreault, A.; Castellucci, V.F.; Chretien, M.; Lazure, C.
Identification, purification, and characterization of the molecular forms of Aplysia californica peptidylglycine alpha-amidating enzyme
J. Neurochem.
66
2596-2605
1996
Aplysia californica
Oyarce, A.M.; Eipper, B.A.
Neurosecretory vesicles contain soluble and membrane-associated monofunctional and bifunctional peptidylglycine alpha-amidating monoxygenase proteins
J. Neurochem.
60
1105-1114
1993
Rattus norvegicus
Girard, B.; Ouafik, L.; Boudouresque, F.
Characterization and regulation of peptidylglycine alpha-amidating monooxygenase (PAM) expression in H9c2 cardiac myoblasts
Cell Tissue Res.
298
489-497
1999
Rattus norvegicus
Merkler, D.J.; Kulathila, R.; Francisco, W.A.; Ash, D.E.; Bell, J.
The irreversible inactivation of two copper-dependent monooxygenases by sulfite: peptidylglycine alpha-amidating enzyme and dopamine beta-monooxygenase
FEBS Lett.
366
165-169
1995
Rattus norvegicus
Takahashi, K.; Onami, T.; Noguchi, M.
Kinetic isotope effects of peptidylglycine a-hydroxylating mono-oxygenase reaction
Biochem. J.
336
131-137
1998
Xenopus laevis
-
Bell, J.; Ash, D.E.; Snyder, L.M.; Kulathila, R.; Blackburn, N.J.; Merkler, D.J.
Structural and functional investigations on the role of zinc in bifunctional rat peptidylglycine alpha-amidating enzyme
Biochemistry
36
16239-16246
1997
Rattus norvegicus (P14925)
Ping, D.; Mounier, C.E.; May, S.W.
Reaction versus subsite stereospecificity of peptidylglycine alpha-monooxygenase and peptidylamidoglycolate lyase, the two enzymes involved in peptide amidation
J. Biol. Chem.
270
29250-29255
1995
Bos taurus
Jaron, S.; Blackburn, N.J.
Characterization of a half-apo derivative of peptidylglycine monooxygenase. Insight into the reactivity of each active site copper
Biochemistry
40
6867-6875
2001
Rattus norvegicus
Francisco, W.A.; Merkler, D.J.; Blackburn, N.J.; Klinman, J.P.
Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction
Biochemistry
37
8244-8252
1998
Rattus norvegicus
Jaron, S.; Mains, R.E.; Eipper, B.A.; Blackburn, N.J.
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase (PHM): a spectroscopic study of the H172A mutant
Biochemistry
41
13274-13282
2002
Rattus norvegicus
Francisco, W.A.; Knapp, M.J.; Blackburn, N.J.; Klinman, J.P.
Hydrogen tunneling in peptidylglycine alpha-hydroxylating monooxygenase
J. Am. Chem. Soc.
124
8194-8195
2002
Rattus norvegicus
Satani, M.; Takahashi, K.; Sakamoto, H.; Harada, S.; Kaida, Y.; Noguchi, M.
Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase
Protein Expr. Purif.
28
293-302
2003
Homo sapiens (P19021), Homo sapiens
Miller, L.A.; Baumgart, L.E.; Chew, G.H.; deLong, M.A.; Galloway, L.C.; Jung, K.W.; Merkler, K.A.; Nagle, A.S.; Poore, D.D.; Yoon, C.H.; Merkler, D.J.
Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase
Arch. Biochem. Biophys.
412
3-12
2003
Rattus norvegicus
Prohaska, J.R.; Gybina, A.A.; Broderius, M.; Brokate, B.
Peptidylglycine-alpha-amidating monooxygenase activity and protein are lower in copper-deficient rats and suckling copper-deficient mice
Arch. Biochem. Biophys.
434
212-220
2005
Mus musculus, Rattus norvegicus
Francisco, W.A.; Blackburn, N.J.; Klinman, J.P.
Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications
Biochemistry
42
1813-1819
2003
Rattus norvegicus
Bell, J.; El Meskini, R.; D'Amato, D.; Mains, R.E.; Eipper, B.A.
Mechanistic investigation of peptidylglycine alpha-hydroxylating monooxygenase via intrinsic tryptophan fluorescence and mutagenesis
Biochemistry
42
7133-7142
2003
Rattus norvegicus
Labrador, V.; Brun, C.; Konig, S.; Roatti, A.; Baertschi, A.J.
Peptidyl-glycine alpha-amidating monooxygenase targeting and shaping of atrial secretory vesicles: inhibition by mutated N-terminal ProANP and PBA
Circ. Res.
95
98-109
2004
Rattus norvegicus
Asada, A.; Orii, H.; Watanabe, K.; Tsubaki, M.
Planarian peptidylglycine-hydroxylating monooxygenase, a neuropeptide processing enzyme, colocalizes with cytochrome b561 along the central nervous system
FEBS J.
272
942-955
2005
Dugesia japonica (Q4W7B5)
Francisco, W.A.; Wille, G.; Smith, A.J.; Merkler, D.J.; Klinman, J.P.
Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase
J. Am. Chem. Soc.
126
13168-13169
2004
Rattus norvegicus
Barratt, B.J.; Easton, C.J.; Henry, D.J.; Li, I.H.; Radom, L.; Simpson, J.S.
Inhibition of peptidylglycine alpha-amidating monooxygenase by exploitation of factors affecting the stability and ease of formation of glycyl radicals
J. Am. Chem. Soc.
126
13306-13311
2004
Rattus norvegicus
Chen, P.; Solomon, E.I.
Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Reaction mechanism and role of the noncoupled nature of the active site
J. Am. Chem. Soc.
126
4991-5000
2004
Rattus norvegicus
Owen, T.C.; Merkler, D.J.
A new proposal for the mechanism of glycine hydroxylation as catalyzed by peptidylglycine alpha-hydroxylating monooxygenase (PHM)
Med. Hypotheses
62
392-400
2004
Rattus norvegicus
Sunman, J.A.; Foster, M.S.; Folse, S.L.; May, S.W.; Matesic, D.F.
Reversal of the transformed phenotype and inhibition of peptidylglycine alpha-monooxygenase in Ras-transformed cells by 4-phenyl-3-butenoic acid
Mol. Carcinog.
41
231-246
2004
Homo sapiens
Takahashi, K.; Satani, M.; Harada, S.; Noguchi, M.
Expression and characterization of frog peptidylglycine alpha-hydroxylating monooxygenase
Protein Expr. Purif.
27
35-41
2003
Xenopus laevis
Bauman, A.T.; Jaron, S.; Yukl, E.T.; Burchfiel, J.R.; Blackburn, N.J.
pH Dependence of peptidylglycine monooxygenase. Mechanistic implications of Cu-methionine binding dynamics
Biochemistry
45
11140-11150
2006
Rattus norvegicus
Evans, J.P.; Blackburn, N.J.; Klinman, J.P.
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase: A kinetic study of the H172A mutant
Biochemistry
45
15419-15429
2006
Cricetulus griseus
Prohaska, J.R.; Broderius, M.
Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice
Comp. Biochem. Physiol. B
143
360-366
2006
Mus musculus, Rattus norvegicus
Chew, G.H.; Galloway, L.C.; McIntyre, N.R.; Schroder, L.A.; Richards, K.M.; Miller, S.A.; Wright, D.W.; Merkler, D.J.
Ubiquitin and ubiquitin-derived peptides as substrates for peptidylglycine alpha-amidating monooxygenase
FEBS Lett.
579
4678-4684
2005
Bos taurus
Crespo, A.; Marti, M.A.; Roitberg, A.E.; Amzel, L.M.; Estrin, D.A.
The catalytic mechanism of peptidylglycine alpha-hydroxylating monooxygenase investigated by computer simulation
J. Am. Chem. Soc.
128
12817-12828
2006
Rattus norvegicus (P14925)
Klinman, J.P.
The copper-enzyme family of dopamine b-monooxygenase and peptidylglycine a-hydroxylating monooxygenase: Resolving the chemical pathway for substrate hydroxylation
J. Biol. Chem.
281
3013-3016
2006
Homo sapiens
Bauman, A.T.; Yukl, E.T.; Alkevich, K.; McCormack, A.L.; Blackburn, N.J.
The hydrogen peroxide reactivity of peptidylglycine monooxygenase supports a Cu(II)-superoxo catalytic intermediate
J. Biol. Chem.
281
4190-4198
2006
Rattus norvegicus
Bauer, J.D.; Sunman, J.A.; Foster, M.S.; Thompson, J.R.; Ogonowski, A.A.; Cutler, S.J.; May, S.W.; Pollock, S.H.
Anti-inflammatory effects of 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester, potential inhibitors of neuropeptide bioactivation
J. Pharmacol. Exp. Ther.
320
1171-1177
2007
Rattus norvegicus
Driscoll, W.J.; Hill, D.; Smalstig, A.; Mueller, G.P.
Murine atrial HL-1 cells express highly active peptidylglycine alpha-amidating enzyme
Peptides
27
1547-1553
2006
Mus musculus
Bauman, A.T.; Ralle, M.; Blackburn, N.J.
Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor
Protein Expr. Purif.
51
34-38
2007
Rattus norvegicus
de la Lande, A.; Marti, S.; Parisel, O.; Moliner, V.
Long distance electron-transfer mechanism in peptidylglycine alpha-hydroxylating monooxygenase: a perfect fitting for a water bridge
J. Am. Chem. Soc.
129
11700-11707
2007
Rattus norvegicus
Merkler, D.J.; Asser, A.S.; Baumgart, L.E.; Carballo, N.; Carpenter, S.E.; Chew, G.H.; Cosner, C.C.; Dusi, J.; Galloway, L.C.; Lowe, A.B.; Lowe, E.W.; King, L.; Kendig, R.D.; Kline, P.C.; Malka, R.; Merkler, K.A.; McIntyre, N.R.; Romero, M.; Wilcox, B.J.; Owen, T.C.
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM)
Bioorg. Med. Chem.
16
10061-10074
2008
Blattella germanica, Homo sapiens, Rattus norvegicus (P14925)
Bousquet-Moore, D.; Ma, X.M.; Nillni, E.A.; Czyzyk, T.A.; Pintar, J.E.; Eipper, B.A.; Mains, R.E.
Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper
Endocrinology
150
1739-1747
2009
Mus musculus
McIntyre, N.R.; Lowe, E.W.; Merkler, D.J.
Imino-oxy acetic acid dealkylation as evidence for an inner-sphere alcohol intermediate in the reaction catalyzed by peptidylglycine alpha-hydroxylating monooxygenase
J. Am. Chem. Soc.
131
10308-10319
2009
Rattus norvegicus (P14925)
Sharma, S.D.; Raghuraman, G.; Lee, M.S.; Prabhakar, N.R.; Kumar, G.K.
Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing
J. Appl. Physiol.
106
12-19
2009
Rattus norvegicus
Trendel, J.A.; Ellis, N.; Sarver, J.G.; Klis, W.A.; Dhananjeyan, M.; Bykowski, C.A.; Reese, M.D.; Erhardt, P.W.
Catalytically active peptidylglycine alpha-amidating monooxygenase in the media of androgen-independent prostate cancer cell lines
J. Biomol. Screen.
13
804-809
2008
Homo sapiens
Bousquet-Moore, D.; Prohaska, J.R.; Nillni, E.A.; Czyzyk, T.; Wetsel, W.C.; Mains, R.E.; Eipper, B.A.
Interactions of peptide amidation and copper: Novel biomarkers and mechanisms of neural dysfunction
Neurobiol. Dis.
37
130-140
2010
Mus musculus
Langella, E.; Pierre, S.; Ghattas, W.; Giorgi, M.; Reglier, M.; Saviano, M.; Esposito, L.; Hardre, R.
Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors
ChemMedChem
5
1568-1576
2010
Sus scrofa
Chufan, E.E.; Prigge, S.T.; Siebert, X.; Eipper, B.A.; Mains, R.E.; Amzel, L.M.
Differential reactivity between two copper sites in peptidylglycine alpha-hydroxylating monooxygenase
J. Am. Chem. Soc.
132
15565-15572
2010
Rattus norvegicus
McIntyre, N.R.; Lowe, E.W.; Belof, J.L.; Ivkovic, M.; Shafer, J.; Space, B.; Merkler, D.J.
Evidence for substrate preorganization in the peptidylglycine alpha-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunneling
J. Am. Chem. Soc.
132
16393-16402
2010
Rattus norvegicus
Bousquet-Moore, D.; Mains, R.E.; Eipper, B.A.
Peptidylgycine alpha-amidating monooxygenase and copper: a gene-nutrient interaction critical to nervous system function
J. Neurosci. Res.
88
2535-2545
2010
Mus musculus
Foster, M.; Oldham, C.; May, S.
Looking glass mechanism-based inhibition of peptidylglycine alpha-amidating monooxygenase
Tetrahedron Asymmetry
22
283-293
2011
Xenopus laevis
-
Handa, S.; Spradling, T.J.; Dempsey, D.R.; Merkler, D.J.
Production of the catalytic core of human peptidylglycine alpha-hydroxylating monooxygenase (hPHMcc) in Escherichia coli
Protein Expr. Purif.
84
9-13
2012
Homo sapiens (P19021), Homo sapiens
Bauman, A.T.; Broers, B.A.; Kline, C.D.; Blackburn, N.J.
A copper-methionine interaction controls the pH-dependent activation of peptidylglycine monooxygenase
Biochemistry
50
10819-10828
2011
Homo sapiens
Kline, C.D.; Mayfield, M.; Blackburn, N.J.
HHM motif at the CuH-site of peptidylglycine monooxygenase is a pH-dependent conformational switch
Biochemistry
52
2586-2596
2013
Homo sapiens
Morris, K.M.; Cao, F.; Onagi, H.; Altamore, T.M.; Gamble, A.B.; Easton, C.J.
Prohormone-substrate peptide sequence recognition by peptidylglycine alpha-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
Bioorg. Med. Chem. Lett.
22
7015-7018
2012
Homo sapiens
Otoikhian, A.; Barry, A.N.; Mayfield, M.; Nilges, M.; Huang, Y.; Lutsenko, S.; Blackburn, N.J.
Lumenal loop M672-P707 of the Menkes protein (ATP7A) transfers copper to peptidylglycine monooxygenase
J. Am. Chem. Soc.
134
10458-10468
2012
Mus musculus
Gaier, E.D.; Miller, M.B.; Ralle, M.; Aryal, D.; Wetsel, W.C.; Mains, R.E.; Eipper, B.A.
Peptidylglycine alpha-amidating monooxygenase heterozygosity alters brain copper handling with region specificity
J. Neurochem.
127
605-619
2013
Mus musculus
Cao, F.; Gamble, A.; Kim, H.; Onagi, H.; Gresser, M.; Kerr, J.; Easton, C.
Potent and selective inhibitors of human peptidylglycine alpha-amidating monooxygenase
MedChemComm
2
760-763
2011
Homo sapiens
-
Attenborough, R.M.; Hayward, D.C.; Kitahara, M.V.; Miller, D.J.; Ball, E.E.
A neural enzyme in nonbilaterian animals and algae: preneural origins for peptidylglycine alpha-amidating monooxygenase
Mol. Biol. Evol.
29
3095-3109
2012
Acropora millepora (J9QK52), Acropora millepora (J9QL63)
Ul-Hasan, S.; Burgess, D.M.; Gajewiak, J.; Li, Q.; Hu, H.; Yandell, M.; Olivera, B.M.; Bandyopadhyay, P.K.
Characterization of the peptidylglycine alpha-amidating monooxygenase (PAM) from the venom ducts of neogastropods, Conus bullatus and Conus geographus
Toxicon
74
215-224
2013
Conus geographus, Conus bullatus
Chauhan, S.; Kline, C.D.; Mayfield, M.; Blackburn, N.J.
Binding of copper and silver to single-site variants of peptidylglycine monooxygenase reveals the structure and chemistry of the individual metal centers
Biochemistry
53
1069-1080
2014
Rattus norvegicus (P14925)
Chauhan, S.; Hosseinzadeh, P.; Lu, Y.; Blackburn, N.J.
Stopped-flow studies of the reduction of the copper centers suggest a bifurcated electron transfer pathway in peptidylglycine monooxygenase
Biochemistry
55
2008-2021
2016
Rattus norvegicus (P14925)
Kline, C.D.; Blackburn, N.J.
Substrate-induced carbon monoxide reactivity suggests multiple enzyme conformations at the catalytic copper M-center of peptidylglycine monooxygenase
Biochemistry
55
6652-6661
2016
Rattus norvegicus (P14925)
Yoo, H.J.; Kim, M.; Kim, M.; Chae, J.S.; Lee, S.H.; Lee, J.H.
The peptidylglycine-alpha-amidating monooxygenase (PAM) gene rs13175330 A>G polymorphism is associated with hypertension in a Korean population
Hum. Genomics
11
29
2017
Homo sapiens (P19021)
Martin-Diaconescu, V.; Chacon, K.N.; Delgado-Jaime, M.U.; Sokaras, D.; Weng, T.C.; DeBeer, S.; Blackburn, N.J.
Kbeta valence to core X-ray emission studies of Cu(I) binding proteins with mixed methionine-histidine coordination. Relevance to the reactivity of the M- and H-sites of peptidylglycine monooxygenase
Inorg. Chem.
55
3431-3439
2016
Rattus norvegicus (P14925)
Vishwanatha, K.; Baeck, N.; Mains, R.E.; Eipper, B.A.
A histidine-rich linker region in peptidylglycine alpha-amidating monooxygenase has the properties of a pH sensor
J. Biol. Chem.
289
12404-12420
2014
Mus musculus (P97467)
Abad, E.; Rommel, J.B.; Kaestner, J.
Reaction mechanism of the bicopper enzyme peptidylglycine alpha-hydroxylating monooxygenase
J. Biol. Chem.
289
13726-13738
2014
Rattus norvegicus (P14925)
Bonnemaison, M.L.; Baeck, N.; Duffy, M.E.; Ralle, M.; Mains, R.E.; Eipper, B.A.
Adaptor protein-1 complex affects the endocytic trafficking and function of peptidylglycine alpha-amidating monooxygenase, a luminal cuproenzyme
J. Biol. Chem.
290
21264-21279
2015
Homo sapiens (P19021), Rattus norvegicus (P14925)
Simpson, P.D.; Eipper, B.A.; Katz, M.J.; Gandara, L.; Wappner, P.; Fischer, R.; Hodson, E.J.; Ratcliffe, P.J.; Masson, N.
Striking oxygen sensitivity of the peptidylglycine alpha-amidating monooxygenase (PAM) in neuroendocrine cells
J. Biol. Chem.
290
24891-24901
2015
Drosophila melanogaster (O01404), Homo sapiens (P19021), Mus musculus (P97467)
McIntyre, N.R.; Lowe, E.W.; Battistini, M.R.; Leahy, J.W.; Merkler, D.J.
Inactivation of peptidylglycine alpha-hydroxylating monooxygenase by cinnamic acid analogs
J. Enzyme Inhib. Med. Chem.
31
551-562
2016
Rattus norvegicus (P14925), Homo sapiens (P19021)
Zielinski, M.; Wojtowicz-Krawiec, A.; Mikiewicz, D.; Kesik-Brodacka, M.; Cecuda-Adamczewska, V.; Marciniak-Rusek, A.; Sokolowska, I.; Lukasiewicz, N.; Gurba, L.; Odrowaz-Sypniewski, M.; Baran, P.; Plucienniczak, G.; Plucienniczak, A.; Borowicz, P.; Szewczyk, B.
Expression of recombinant human bifunctional peptidylglycine alpha-amidating monooxygenase in CHO cells and its use for insulin analogue modification
Protein Expr. Purif.
119
102-109
2016
Homo sapiens (P19021)
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