1.14.17.1: dopamine beta-monooxygenase
This is an abbreviated version!
For detailed information about dopamine beta-monooxygenase, go to the full flat file.
Word Map on EC 1.14.17.1
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1.14.17.1
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catecholamine
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noradrenergic
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norepinephrine
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nerve
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sympathetic
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noradrenaline
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adrenal
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innervation
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medulla
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fiber
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dopaminergic
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neuropeptide
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chromaffin
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adrenergic
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monoamine
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neurotransmitter
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ganglia
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coeruleus
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hypothalamus
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catecholaminergic
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phenylethanolamine
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npy
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epinephrine
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cholinergic
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adrenaline
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phenylethanolamine-n-methyltransferase
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n-methyltransferase
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varicosity
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vasoactive
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rostrally
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reserpine
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gene-related
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catecholamine-synthesizing
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disulfiram
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peptidylglycine
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preganglionic
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adrenomedullary
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th-immunoreactive
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orthostatic
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preoptic
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ventrolateral
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monoaminergic
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parabrachial
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saporin
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intermediolateral
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hydroxylase-immunoreactive
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cytoarchitectonic
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medicine
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drug development
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postrema
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diagnostics
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histofluorescence
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alpha-methyl-p-tyrosine
- 1.14.17.1
- catecholamine
-
noradrenergic
- norepinephrine
- nerve
-
sympathetic
- noradrenaline
- adrenal
-
innervation
- medulla
- fiber
-
dopaminergic
-
neuropeptide
-
chromaffin
-
adrenergic
-
monoamine
-
neurotransmitter
- ganglia
- coeruleus
- hypothalamus
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catecholaminergic
- phenylethanolamine
- npy
- epinephrine
-
cholinergic
- adrenaline
-
phenylethanolamine-n-methyltransferase
- n-methyltransferase
-
varicosity
-
vasoactive
-
rostrally
- reserpine
-
gene-related
-
catecholamine-synthesizing
- disulfiram
- peptidylglycine
-
preganglionic
-
adrenomedullary
-
th-immunoreactive
-
orthostatic
-
preoptic
-
ventrolateral
-
monoaminergic
-
parabrachial
- saporin
-
intermediolateral
-
hydroxylase-immunoreactive
-
cytoarchitectonic
- medicine
- drug development
- postrema
- diagnostics
-
histofluorescence
- alpha-methyl-p-tyrosine
Reaction
Synonyms
3,4-dihydroxy-phenylethylamine, ascorbate: oxygen oxidoreductase (3-hydroxylating), 3,4-dihydroxyphenethylamine beta-oxidase, 3,4-dihydroxyphenylethylamine beta-hydoxylase, 4-(2-aminoethyl)pyrocatechol beta-oxidase, DbetaH, DbetaM, DBH, DBM, Dopa beta-hydroxylase, dopamine beta hydroxylase, dopamine beta-hydrolase, dopamine beta-hydroxylase, dopamine beta-mono-oxygenase, dopamine beta-monooxygenase, dopamine beta-oxidase, dopamine hydroxylase, dopamine(3,4-dihydroxyphenethylamine)beta-mono-oxygenase, dopamine-B-hydroxylase, dopamine-beta hydroxylase, dopamine-beta-hydroxylase, dopamine-beta-monooxygenase, EC 1.14.2.1, gDBH, LvDBH, MDBH, oxygenase, dopamine beta-mono-, pDbetaH, phenylamine beta-hydroxylase, plasma DbetaH activity, plasma dopamine beta-hydroxylase, plDbetaH, SDBH, TBetaM, tyramine beta-monooxygenase
ECTree
1.14.17.1 dopamine beta-monooxygenaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.14.17.1 - dopamine beta-monooxygenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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the DBH activity:DBH protein ratio is the same in human serum and cerebrospinal fluid and does not change in patients with Parkinson disease, whose cerebrospinal fluid has very low DBH activity and protein levels compared with cerebrospinal fluid from healthy individuals
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a 75% decrease of dopamine-beta-hydroxyase expression is observed in rats exposed to 2,4-dichlorophenoxyacetic acid through lactation for 14 days
additional information
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dietary copper deficiency is associated with increased formation of enzyme
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438597, 438601, 438604, 438606, 438607, 438613, 438614, 438615, 438617, 438619, 438621, 438623, 438624, 438628, 438629, 438630, 438635, 657766, 657814, 659086
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a functional -1021C3T polymorphism in the DBH gene regulates plasma DBH activity, and individuals with the genotype T/T have genetically determined low DBH activity in their plasma
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dopamine beta-hydroxyase is reduced in rats subjected to chronic mild stress for 5 weeks. Imipramine treatment minimizes these chronic mild stress-induced reductions
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enzyme activity in children and adolescents increases with the age between 3-10 years, later it decreases approximately by the age of 10-14 years. At the age of 21 to 60 years the dopamine-beta-hydroxylase level is stable
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activity is highest in 5-day-old rats, it decreases till the age of 14 days and increases mainly in 14-day to 35-day-old animals, significant decrease in activity in rats between 35 to 40 days, adult rats aged 90-120 days show a stable activity of dopamine bet-hydroxylase
age-related changes in immunoreactivity for dopamine beta-hydroxylase in carotid body glomus cells in spontaneously hypertensive rats
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age-related changes in immunoreactivity for dopamine beta-hydroxylase in carotid body glomus cells in spontaneously hypertensive rats
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axons expressing dopamine beta hydroxyase frequenty made appositions to sympathetic and parasympathetic preganglionic neurons
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enzyme activity in plasma from combat veterans with or without chronic posttraumatic stress disorder, non-normal distribution, overview
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taste disc of the tongue, DBH-like immunoreactive cells are located in the intermediate layer in the taste disc, the cells show an apical process reaching the surface of the disc and one or several basal processes, overview
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DBM protein is present in Cu-negative samples but not in Cu-positive samples
additional information
gDBH expression is found between the hypothalamus-pituitary and oviduct during the ovulation phase and the broody phase, real-time quantitative PCR enzyme expression analysis. The enzyme expression is higher in animals with higher egg production than in those with low egg production. Analysis of temporal expression patterns of gDBH expression in the hypothalamus, pituitary, ovary, and oviduct tissues during different stages of the goose reproductive cycle, specifically the pre-laying stage, ovulation, oviposition, and the broody phase reveals that the expression is lowest in all tissues during the oviposition phase. It is high in the hypothalamus, ovary, and pituitary in the pre-laying period. High expression of DBH is also found in the cerebrum and cerebellum due to the involvement of norepinephrine and epinephrine in neuroendocrine processes
additional information
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immunohistochemic localization analysis, overview
additional information
determination of tissue distribution of enzyme expression by quantitative real-time PCR enzyme expression analysis
additional information
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determination of tissue distribution of enzyme expression by quantitative real-time PCR enzyme expression analysis
