1.14.16.7: phenylalanine 3-monooxygenase

This is an abbreviated version!
For detailed information about phenylalanine 3-monooxygenase, go to the full flat file.

PacX, phenylalanine 3-hydroxylase

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Results	in table
1	Activating Compound
2	AA Sequence
1	Cloned(Commentary)
1	General Information
2	KM Value [mM]
1	Metals/Ions
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
3	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reference
3	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products on EC 1.14.16.7 - phenylalanine 3-monooxygenase

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L-phenylalanine + 6-methyltetrahydropterin + O2

3-hydroxy-L-phenylalanine + 4a-hydroxy-6-methyltetrahydropterin

L-phenylalanine + tetrahydrobiopterin + O2

3-hydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin

the enzyme forms 3-hydroxy-L-phenylalanine (i.e. m-L-tyrosine) which is one of the building blocks in the biosynthesis of pacidamycins

3-hydroxy-L-phenylalanine i.e. m-L-Tyr

additional information

no activity with D-Phe, L-Tyr, and L-Trp