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1.14.16.6: mandelate 4-monooxygenase

This is an abbreviated version!
For detailed information about mandelate 4-monooxygenase, go to the full flat file.

Reaction

(S)-2-Hydroxy-2-phenylacetate
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
(S)-4-hydroxymandelate
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

L-mandelate-4-hydroxylase, mandelic acid 4-hydroxylase, oxygenase, mandelate 4-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.6 mandelate 4-monooxygenase

Systematic Name

Systematic Name on EC 1.14.16.6 - mandelate 4-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
(S)-2-hydroxy-2-phenylacetate,tetrahydropteridine:oxygen oxidoreductase (4-hydroxylating)
Requires Fe2+. The enzyme has been characterized from the bacterium Pseudomonas putida. The 4a-hydroxytetrahydropteridine formed can dehydrate to 6,7-dihydropteridine, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydropteridine must be enzymically reduced back to tetrahydropteridine, by EC 1.5.1.34, 6,7-dihydropteridine reductase, before it slowly rearranges into the more stable but inactive compound 7,8-dihydropteridine.