Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.16.5: alkylglycerol monooxygenase

This is an abbreviated version!
For detailed information about alkylglycerol monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.5

Reaction

1-O-alkyl-sn-glycerol
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
1-O-(1-hydroxyalkyl)-sn-glycerol
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

AGMO, alkylglycerol mono-oxygenase, alkylglycerol monooxygenase, EC 1.14.99.17, glyceryl ether hydroxylase, glyceryl ether monooxygenase, glyceryl ether oxidase, glyceryl ether oxygenase, glyceryl ether-cleaving enzyme, glyceryl etherase, glyceryl-ether cleaving enzyme, O-alkylglycerol monooxygenase, oxygenase, glyceryl ether mono-, PRUB680

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.5 alkylglycerol monooxygenase

Reference

Reference on EC 1.14.16.5 - alkylglycerol monooxygenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Soodsma, J.F.; Piantadosi, C.; Snyder, F.
Partial characterization of the alkylglycerol cleavage enzyme system of rat liver
J. Biol. Chem.
247
3923-3929
1972
Rattus norvegicus
Manually annotated by BRENDA team
Ishibashi, T.; Imai, Y.
Solubilization and partial characterization of alkylglycerol monooxygenase from rat liver microsomes
Eur. J. Biochem.
132
23-27
1983
Rattus norvegicus
Manually annotated by BRENDA team
Pfleger, R.C.; Piantadosi, C.; Snyder, F.
The biocleavage of isomeric glyceryl ethers by soluble liver enzymes in a variety of species
Biochim. Biophys. Acta
144
633-648
1967
Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Limax maximus, Meriones sp., Mesocricetus auratus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Snyder, F.; Malone, B.; Piantadosi, C.
Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity
Biochim. Biophys. Acta
316
259-265
1973
Rattus norvegicus
Manually annotated by BRENDA team
Ishibashi, T.; Imai, Y.
Affinity purification of alkylglycerol monooxygenase from rat liver microsomes by chimyl alcohol-Sepharose 4B column chromatography
J. Lipid Res.
26
393-395
1985
Rattus norvegicus
Manually annotated by BRENDA team
Rock, C.O.; Baker, R.C.; Fitzgerald, V.; Snyder, F.
Stimulation of the microsomal alkylglycerol monooxygenase by catalase
Biochim. Biophys. Acta
450
469-473
1976
Rattus norvegicus
Manually annotated by BRENDA team
Armarego, W.L.F.
Glyceryl-ether monooxygenase [EC 1.14.16.5] a mixed function oxidase requiring oxygen and a tetrahydropterin cofactor
Pteridines
7
90
1996
Rattus norvegicus
-
Manually annotated by BRENDA team
Kosar-Hashemi, B.; Taguchi, H.; Armarego, W.L.F.
Glyceryl-ether monooxygenase [EC 1.14.16.5]. Part V: Some aspects of the stoichiometry
Pteridines
5
1-7
1994
Rattus norvegicus
-
Manually annotated by BRENDA team
Kurisu, T.; Taguchi, H.; Paal, B.; Yang, N.; Armarego, W.L.F.
Glyceryl-ether monooxygenase [EC 1.14.16.5] Part VII. Effects of alkyl phosphocholines and acyl L-alpha-lyso-phosphatidylcholines detergents on enzyme activity
Pteridines
5
95-101
1994
Rattus norvegicus
-
Manually annotated by BRENDA team
Taguchi, H.; Armarego, W.L.F.
Glyceryl-ether monooxygenase [EC 1.14.16.5]. A microsomal enzyme of ether lipid metabolism
Med. Res. Rev.
18
43-89
1998
Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Meriones sp., Mesocricetus auratus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kosar-Hashemi, B.; Taguchi, H.; Armarego, W.L.F.
Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition
Adv. Exp. Med. Biol.
338
93-96
1993
Rattus norvegicus
Manually annotated by BRENDA team
Taguchi, H.; Paal, B.; Armarego, W.L.F.
Glyceryl-ether monooxygenase [EC 1.14.16.5]. Part VIII. Probing the nature of the active site
Pteridines
6
45-57
1995
Rattus norvegicus
-
Manually annotated by BRENDA team
Kosar-Hashemi, B.; Armarego, W.L.F.
A convenient spectrophotometric method for measuring the kinetic parameters of glyceryl-ether monooxygenase (EC 1.14.16.5)
Biol. Chem. Hoppe-Seyler
374
9-25
1993
Rattus norvegicus
Manually annotated by BRENDA team
Taguchi, H.; Paal, B.; Armarego, W.L.F.
Glyceryl-ether monooxygenase [EC 1.14.16.5]. Part IX. Stereospecificity of the oxygenase reaction
J. Chem. Soc. Perkin Trans. I
1997
303-307
1997
Rattus norvegicus
-
Manually annotated by BRENDA team
Taguchi, H.; Kosar-Hashemi, B.; Paal, B.; Yang, N.; Armarego, W.L.F.
Glyceryl-ether monooxygenase (EC 1.14.16.5), part VI.: nature of the glyceryl-ether lipid substrates in aqueous buffer
Biol. Chem. Hoppe-Seyler
375
329-334
1994
Rattus norvegicus
Manually annotated by BRENDA team
Werner, E.R.; Hermetter, A.; Prast, H.; Golderer, G.; Werner-Felmayer, G.
Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay
J. Lipid Res.
48
1422-1427
2007
Rattus norvegicus
Manually annotated by BRENDA team
Watschinger, K.; Keller, M.A.; Hermetter, A.; Golderer, G.; Werner-Felmayer, G.; Werner, E.R.
Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence
Biol. Chem.
390
3-10
2009
Rattus norvegicus
Manually annotated by BRENDA team
Watschinger, K.; Keller, M.A.; Golderer, G.; Hermann, M.; Maglione, M.; Sarg, B.; Lindner, H.H.; Hermetter, A.; Werner-Felmayer, G.; Konrat, R.; Hulo, N.; Werner, E.R.
Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes
Proc. Natl. Acad. Sci. USA
107
13672-13677
2010
Homo sapiens
Manually annotated by BRENDA team
Tokuoka, S.M.; Kita, Y.; Shindou, H.; Shimizu, T.
Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages
Biochem. Biophys. Res. Commun.
436
306-312
2013
Mus musculus
Manually annotated by BRENDA team
Watschinger, K.; Fuchs, J.E.; Yarov-Yarovoy, V.; Keller, M.A.; Golderer, G.; Hermetter, A.; Werner-Felmayer, G.; Hulo, N.; Werner, E.R.
Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase
Biochem. J.
443
279-286
2012
Homo sapiens
Manually annotated by BRENDA team
Watschinger, K.; Werner, E.R.
Alkylglycerol monooxygenase
IUBMB Life
65
366-372
2013
Danio rerio, Caenorhabditis elegans, no activity in Drosophila melanogaster, Rattus norvegicus
Manually annotated by BRENDA team
Marquet, S.; Bucheton, B.; Reymond, C.; Argiro, L.; El-Safi, S.H.; Kheir, M.M.; Desvignes, J.P.; Beroud, C.; Mergani, A.; Hammad, A.; Dessein, A.J.
Exome sequencing identifies two variants of the alkylglycerol monooxygenase gene as a cause of relapses in visceral leishmaniasis in children, in Sudan
J. Infect. Dis.
216
22-28
2017
Homo sapiens
Manually annotated by BRENDA team
Alrayes, N.; Mohamoud, H.S.; Ahmed, S.; Almramhi, M.M.; Shuaib, T.M.; Wang, J.; Al-Aama, J.Y.; Everett, K.; Nasir, J.; Jelani, M.
The alkylglycerol monooxygenase (AGMO) gene previously involved in autism also causes a novel syndromic form of primary microcephaly in a consanguineous Saudi family
J. Neurol. Sci.
363
240-244
2016
Homo sapiens (Q6ZNB7), Homo sapiens
Manually annotated by BRENDA team
de Rond, T.; Stow, P.; Eigl, I.; Johnson, R.E.; Chan, L.J.G.; Goyal, G.; Baidoo, E.E.K.; Hillson, N.J.; Petzold, C.J.; Sarpong, R.; Keasling, J.D.
Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme
Nat. Chem. Biol.
13
1155-1157
2017
Pseudoalteromonas rubra
Manually annotated by BRENDA team
Watschinger, K.; Keller, M.A.; McNeill, E.; Alam, M.T.; Lai, S.; Sailer, S.; Rauch, V.; Patel, J.; Hermetter, A.; Golderer, G.; Geley, S.; Werner-Felmayer, G.; Plumb, R.S.; Astarita, G.; Ralser, M.; Channon, K.M.; Werner, E.R.
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome
Proc. Natl. Acad. Sci. USA
112
2431-2436
2015
Mus musculus
Manually annotated by BRENDA team