1.14.16.4: tryptophan 5-monooxygenase
This is an abbreviated version!
For detailed information about tryptophan 5-monooxygenase, go to the full flat file.
Word Map on EC 1.14.16.4
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1.14.16.4
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serotonin
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serotonergic
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raphe
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5-hydroxytryptamine
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monoamine
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dorsal
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dopamine
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neurotransmitter
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hippocampus
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antidepressant
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reuptake
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5-hydroxytryptophan
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anxiety
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psychiatric
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midbrain
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striatum
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hypothalamus
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neurochemical
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5-hydroxyindoleacetic
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mood
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enterochromaffin
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neurotransmission
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5-hiaa
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p-chlorophenylalanine
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fluoxetine
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pineal
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brainstem
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alpha-methyl-p-tyrosine
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monoaminergic
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5,7-dihydroxytryptamine
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analysis
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methamphetamine
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autoreceptors
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slc6a4
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immobility
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pargyline
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n-acetylserotonin
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neostriatal
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5-httlpr
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medicine
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citalopram
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antidepressant-like
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carcinoid
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biopterins
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impulsivity
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oxidase-a
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tetrahydropterins
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fenfluramine
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impulsive
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8-oh-dpat
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5-hydroxyindole
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drug development
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3,4-methylenedioxymethamphetamine
- 1.14.16.4
- serotonin
-
serotonergic
-
raphe
- 5-hydroxytryptamine
-
monoamine
-
dorsal
- dopamine
-
neurotransmitter
- hippocampus
-
antidepressant
-
reuptake
- 5-hydroxytryptophan
-
anxiety
-
psychiatric
- midbrain
- striatum
- hypothalamus
-
neurochemical
-
5-hydroxyindoleacetic
-
mood
-
enterochromaffin
-
neurotransmission
-
5-hiaa
- p-chlorophenylalanine
- fluoxetine
-
pineal
- brainstem
- alpha-methyl-p-tyrosine
-
monoaminergic
-
5,7-dihydroxytryptamine
- analysis
- methamphetamine
-
autoreceptors
-
slc6a4
-
immobility
- pargyline
- n-acetylserotonin
- neostriatal
-
5-httlpr
- medicine
- citalopram
-
antidepressant-like
- carcinoid
- biopterins
-
impulsivity
-
oxidase-a
- tetrahydropterins
- fenfluramine
-
impulsive
-
8-oh-dpat
- 5-hydroxyindole
- drug development
- 3,4-methylenedioxymethamphetamine
Reaction
Synonyms
hTPH2, indoleacetic acid-5-hydroxylase, L-tryptophan 5-hydroxylase, L-tryptophan hydroxylase, oxygenase, tryptophan 5-mono-, peripheral tryptophan hydroxylase, PTMO, putative tryptophan monooxygenase, TH2, TPH, TPH-1, TPH-2, TPH1, TPH2, TRpOH, tryptophan 5-hydroxylase, tryptophan 5-monooxygenase, tryptophan hydroxylase, tryptophan hydroxylase 1, tryptophan hydroxylase 2, tryptophan hydroxylase I, tryptophan hydroxylase isoform 1, tryptophan hydroxylase isoform 2, tryptophan hydroxylase isoform2, tryptophan hydroxylase type I, tryptophan hydroxylase-1, tryptophan hydroxylase-2, tryptophan-5-hydroxylase
ECTree
Advanced search results
KM Value
KM Value on EC 1.14.16.4 - tryptophan 5-monooxygenase
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0.0128
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TPH2 fusion protein with maltose-binding protein
0.0265
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
doubly truncated enzyme form DELTANH102-DELTACOOH402
0.027
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
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TPH as fusion protein with maltose-binding protein expressed in Escherichia coli
0.027
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
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TPH1 fusion protein with maltose-binding protein
0.039
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
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TPH expressed in Pichia pastoris
0.146
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
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TPH1, in vitro transcription and translation product
0.281
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin
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TPH2, in vitro transcription and translation product
0.0344
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
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biphasic kinetic, low Km value
0.796
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
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biphasic kinetic, high Km value
0.006
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soluble enzyme from brain
0.055
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substrate L-tryptophan
0.125
2-amino-4-hydroxy-6-methyltetrahydropteridine
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tryptohan hydroxylase form I
0.0146
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recombinant N- and C-terminal truncated enzyme, substrate phenylalanine
0.177
6-methyltetrahydropterin
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recombinant N- and C-terminal truncated enzyme, substrate tryptophan
0.0606
L-phenylalanine
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recombinant N- and C-terminal truncated enzyme, cofactor tetrahydrobiopterin
0.1
L-phenylalanine
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cofactor 2-amino-4-hydroxy-6-methyltetrahydropteridine
0.102
L-phenylalanine
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recombinant N- and C-terminal truncated enzyme, cofactor 6-methyltetrahydropterin
0.0058
L-tryptophan
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recombinant N- and C-terminal truncated enzyme, cofactor 6-methyltetrahydrobipterin
0.0075
L-tryptophan
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TPH as fusion protein with maltose-binding protein expressed in Escherichia coli
0.0132
L-tryptophan
0.02 mM ferrous ammonium, 0.5 mM (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, 30°C
0.0282
L-tryptophan
pH 7.0, 30°C, recombinant wild-type TPH2 fusion enzyme
0.0449
L-tryptophan
pH 7.0, 30°C, recombinant phosphorylated wild-type TPH2
0.045
L-tryptophan
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cofactor 2-amino-4-hydroxy-6-methyltetrahydropteridine
0.0479
L-tryptophan
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recombinant N- and C-terminal truncated enzyme, cofactor tetrahydrobiopterin
0.0545
L-tryptophan
pH 7.0, 30°C, recombinant non-phosphorylated wild-type TPH2
0.0142
tetrahydrobiopterin
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recombinant N- and C-terminal truncated enzyme, substrate phenylalanine
0.0147
tetrahydrobiopterin
pH 7.0, 30°C, recombinant mutant P449R fusion enzyme
0.0217
tetrahydrobiopterin
pH 7.0, 30°C, recombinant wild-type TPH2 fusion enzyme
0.0249
tetrahydrobiopterin
pH 7.0, 30°C, recombinant mutant R441H fusion enzyme
0.0289
tetrahydrobiopterin
pH 7.0, 30°C, recombinant detagged mutant R441H
0.0351
tetrahydrobiopterin
pH 7.0, 30°C, recombinant non-phosphorylated wild-type TPH2
0.0423
tetrahydrobiopterin
pH 7.0, 30°C, recombinant phosphorylated wild-type TPH2
0.0518
tetrahydrobiopterin
pH 7.0, 30°C, recombinant detagged mutant P449R
0.0684
tetrahydrobiopterin
pH 7.0, 30°C, recombinant detagged wild-type TPH2
0.135
tetrahydrobiopterin
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recombinant N- and C-terminal truncated enzyme, substrate tryptophan
0.078
tryptophan
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cofactor 2-amino-4-hydroxy-6-methyltetrahydropteridine
0.29
tryptophan
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cofactor 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine
additional information
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1.2% O2 with 0.2 mM 2-amino-4-hydroxy-6-methyl-5,6,7,8-tetrahydropteridine, 7.1% O2 with 0.4 mM 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine
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additional information
additional information
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20% O2, cofactor 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydropteridine, 2.5% O2, cofactor tetrahydrobipterine
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additional information
additional information
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the KM-value of TrpOH in the cerebral cortex and in the brainstem from diabetic rates are significantly increased when compared to those from control rats
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additional information
additional information
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isozymes TPH1 and TPH2 kinetics, overview
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additional information
additional information
isozymes TPH1 and TPH2 kinetics, overview
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additional information
additional information
kinetic mechanism of isozyme TPH1
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additional information
additional information
kinetic mechanism of isozyme TPH1
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additional information
additional information
kinetic mechanism of isozyme TPH1
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additional information
additional information
kinetic mechanism of isozyme TPH1
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additional information
additional information
kinetic mechanism of isozyme TPH2
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additional information
additional information
kinetic mechanism of isozyme TPH2
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additional information
additional information
kinetic mechanism of isozyme TPH2
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additional information
additional information
kinetic mechanism of isozyme TPH2
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additional information
additional information
kinetics of phosphorylated and non-phosphorylated wild-type and mutant enzymes
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additional information
additional information
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kinetics of phosphorylated and non-phosphorylated wild-type and mutant enzymes
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additional information
additional information
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kinetics of wild-type isozyme TPH1, overview
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additional information
additional information
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kinetics of wild-type isozyme TPH2 and of TPH2 deletion mutants, overview
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