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1.14.16.2: tyrosine 3-monooxygenase

This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.2

Reaction

L-tyrosine
+
a 5,6,7,8-tetrahydropteridine
 +
O2
=
L-Dopa
 +
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.2 tyrosine 3-monooxygenase

Specific Activity

Specific Activity on EC 1.14.16.2 - tyrosine 3-monooxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00003
-
crude extract
0.0002
-
about, MN9D cells
0.00045
-
about, MN9D cells induced by forskolin or 8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate
0.00368
-
activity of tyrosine hydroxylase, control level without treatment of L-DOPA in PC-12 cells
0.0054
-
crude enzyme, at pH 6.8 and 37°C
0.0163
-
purified enzyme, at pH 6.8 and 37°C
0.03 - 0.1
-
recombinant enzyme, cell lysate
0.04
-
purified enzyme
0.0447
-
activity in melanosomes
0.0916
-
purified enzyme from brain
0.16
-
purified recombinant isoform hTH3
0.18
-
purified enzyme from adrenal medulla
0.21
-
purified enzyme
0.29
-
purified recombinant isoform hTH2
0.33
-
purified recombinant isoform hTH1, tyrosine concentration is 0.2 mM
0.36
-
purified enzyme
0.41
-
purified enzyme
0.425
-
purified enzyme
0.555
-
with 0.05 mM L-tyrosine, at pH 7.0 and 25°C
0.78
-
purified enzyme
0.79
-
purified recombinant isoform hTH1, tyrosine concentration is 0.05 mM
0.82
-
pH 6.9, 37°C
1
-
about, purified recombinant enzyme
1.6
-
purified enzyme
1.7
-
purified, recombinant enzyme
1.88
-
purified enzyme
101
-
L-tyramine, crude extract of mature leaves, pH 6.0, 37°C
113
-
L-tyrosine, crude extract of mature leaves, pH 6.0, 37°C
1604
-
purified enzyme
2.5
-
purified enzyme, tyrosine concentration is 0.2 mM
20.7
-
purified enzyme, tyrosine concentration is 0.05 mM
3.46
-
purified enzyme, immobilized
330
-
purified enzyme
68800
-
with 1 mM L-tyrosine, at pH 7.0 and 25°C
additional information