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1.14.16.2: tyrosine 3-monooxygenase

This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.2

Reaction

L-tyrosine
+
a 5,6,7,8-tetrahydropteridine
 +
O2
=
L-Dopa
 +
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.2 tyrosine 3-monooxygenase

General Stability

General Stability on EC 1.14.16.2 - tyrosine 3-monooxygenase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
0.1 M 2-mercaptoethanol is necessary for stabilization during purification
-
binding of inhibitor dopamine and of cofactor tetrahydrobioterin stabilizes the enzyme
-
catecholamine binding improves tyrosine hydroxylase's resistance to proteolysis
-
EDTA, 0.1 mM stabilizes
-
enzyme is stabilized by immobilization on polyacrylamide-based support
-
glycerol, 25% stabilizes
-
heparin stabilizes
-
phosphorylated enzyme is less stable than nonphosphorylated form
the 14-3-3eta protein regulates tyrosine hydroxylase type 1 stability against degradation by acting on the N-terminus
-
Tween 80, 0.05% stabilizes
-