1.14.16.2: tyrosine 3-monooxygenase
This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.16.2
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1.14.16.2
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dopamine
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dopaminergic
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parkinsonism
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nigra
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striatum
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catecholamine
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substantia
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nerve
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ventral
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fiber
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sympathetic
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innervation
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adrenal
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noradrenergic
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neurotransmitter
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6-hydroxydopamine
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ganglia
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th-positive
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catecholaminergic
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neuropeptide
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norepinephrine
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nigrostriatal
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midbrain
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monoamine
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neurotrophic
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compacta
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coeruleus
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hypothalamus
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tegmental
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mesencephalic
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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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l-dopa
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6-ohda
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neurochemical
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accumbens
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noradrenaline
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rostrally
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dopac
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apomorphine
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perikarya
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intrastriatal
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beta-hydroxylase
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mptp-induced
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varicosity
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ventrolateral
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dopamine-beta-hydroxylase
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preoptic
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npy
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phenylethanolamine
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analysis
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diagnostics
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homovanillic
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synthesis
- 1.14.16.2
- dopamine
-
dopaminergic
- parkinsonism
- nigra
- striatum
- catecholamine
-
substantia
- nerve
-
ventral
- fiber
-
sympathetic
-
innervation
- adrenal
-
noradrenergic
-
neurotransmitter
- 6-hydroxydopamine
- ganglia
-
th-positive
-
catecholaminergic
-
neuropeptide
- norepinephrine
-
nigrostriatal
- midbrain
-
monoamine
-
neurotrophic
- compacta
- coeruleus
- hypothalamus
- tegmental
-
mesencephalic
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- l-dopa
-
6-ohda
-
neurochemical
- accumbens
- noradrenaline
-
rostrally
-
dopac
- apomorphine
- perikarya
-
intrastriatal
- beta-hydroxylase
-
mptp-induced
-
varicosity
-
ventrolateral
- dopamine-beta-hydroxylase
-
preoptic
- npy
- phenylethanolamine
- analysis
- diagnostics
-
homovanillic
- synthesis
Reaction
Synonyms
CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase
ECTree
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General Information
General Information on EC 1.14.16.2 - tyrosine 3-monooxygenase
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malfunction
metabolism
physiological function
malfunction
suppression of enzyme expression results in cuticle tanning defects and impaired immunity with dramatically decreased survival rates and life spans of pupae
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tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis
metabolism
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tyrosine hydroxylase is the rate-limiting enzyme in catecholamine biosynthesis
metabolism
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rate-limiting enzyme of catecholamine biosynthesis, regulated by phosphorylation, phosphorylation of Ser40 results in a decrease in affinity for catecholamines, phosphorylation of Ser31 results in a decrease in KM value for tetrahydrobiopterin, modified in the presence of NO, resulting in nitration of tyrosine residues (loss of activity) and the glutathionylation of cysteine residues
metabolism
the enzyme performs the rate-limiting step in catecholamine synthesis
metabolism
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tyrosine hydroxylase is the key enzyme in the synthesis of dopamine
metabolism
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tyrosine hydroxylase is the key enzyme in the synthesis of dopamine
metabolism
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tyrosine hydroxylase is the key enzyme in the synthesis of dopamine
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enzyme overexpression is involved in the pupal melanization of Spodoptera exigua
physiological function
the enzyme is crucial for maintaining pupal tanning and immunity in Anopheles sinensis
physiological function
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The enzyme shows a disruptive effect on cell membranes. Incubation of isolated mitochondria with the enzyme leads to a decrease in the mitochondrial membrane potential
physiological function
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tyrosine hydroxylase coordinates larval-pupal tanning and immunity in Bactrocera dorsalis
physiological function
tyrosine hydroxylase gene overexpression promotes the polarization and differentiation of CD4+ cells towards Th2 cells