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1.14.15.3: alkane 1-monooxygenase

This is an abbreviated version!
For detailed information about alkane 1-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.3

Reaction

Octane
+
reduced rubredoxin
+
O2
+ 2 H+ =
1-Octanol
+
oxidized rubredoxin
+
H2O

Synonyms

1-hydroxylase, alkane 1-hydrolase, alkane hydroxylase, alkane mono-oxygenase, alkane monooxygenase, alkane omega-hydroxylase, alkane-1-monooxygenase 1, alkane-1-monooxygenase 2, AlkB, AlkB1, AlkB2, AlkW1, AlkW2, AlmA, AlmA-like alkane hydroxylase, BMO, butane monooxygenase, CYP omega hydroxylase, CYP omega-hydroxylase, Cyp153, CYP153 homologue, CYP153A, CYP153D17, CYP4 P450, CYP450 4A omega-hydroxylase, CYP450 omega-hydroxylase, CYP4A, CYP4A10, CYP4A11, CYP4A14, CYP4AII, CYP4d21, CYP86A1, CYP86B1, CYP94A1, CYPA11 P450, CYPIVA1, CYPIVA11, CYPIVA2, CYPIVA3, CYPIVA5, CYPIVA6, CYPIVA7, cytochrome P-450 omega-hydroxylase, cytochrome P450 alkane hydroxylase, cytochrome P450 omega hydroxylase, cytochrome P450-dependent fatty acid omega-hydroxylase, diiron omega-hydroxylase, FA omega-hydroxylase, fatty acid omega-hydrolase, Fatty acid omega-hydroxylase, Gpo1, hexane hydroxylase, Lauric acid omega-hydroxylase, MAH1-1, MAH1-2, male-specific fatty acid omega-hydroxylase, medium-chain alkane hydroxylase, methane monooxygenase, More, omega hydroxylase, omega-hydrolase, omega-hydroxylase, P-450 HK omega, P450-HL-omega, P452, Prm1ABCD, Prm2ABCD, propane monooxygenase, Rieske-type alkane monooxygenase, sex-specific enzyme 1, SXE1, UAM-Ps1, very long chain fatty acid hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.15.3 alkane 1-monooxygenase

Inhibitors

Inhibitors on EC 1.14.15.3 - alkane 1-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-N'-(4-butyl-2-methylphenyl)-N-hydroxyformimidamide
1,1-dichloroethene
-
50% of BMO activity is irreversibly lost after oxidation of approximately 25 nmol/mg protein
1,2-cis-dichloroethene
-
50% of BMO activity is lost after oxidation of 120 nmol/mg protein
1,2-trans-dichloroethene
-
50% of BMO activity is lost after oxidation of 20 nmol/mg protein
1,7-octadiyne
-
inhibits oxidation of methyl tert-butyl ether; putative mechanism-based inactivator, strongly inhibitory at 0.1% (v/v)
1-octyne
11-dodecynoic acid
17-octadecynoic acid
8-hydroxyquinoline
diethyldithiocarbamate
-
reduces activity to 88%
Fe2+
-
in 0.5 mM concentration, 100% inhibition
Hg2+
-
0.1 mM concentration, 100% inhibition
menadione
-
-
n-alkanes
-
C5-C10 inhibits oxidation of methyl tert-butyl ether, weaker inhibition at longer chain length
n-butane
-
inhibits oxidation of methyl tert-butyl ether
n-decane
-
0.1% (v/v)
n-decyl-beta-D-maltopyranoside
-
-
n-dodecane
-
0.1% (v/v)
n-dodecyl-beta-D-maltopyranoside
-
-
n-dodecyl-N,N-dimethylamine-n-oxide
-
-
n-heptane
-
0.1% (v/v)
n-hexane
-
0.1% (v/v)
N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine
-
HET0016, a potent and selective inhibitor of CYP omega-hydroxylase, significantly inhibits myocardial apoptosis. Pretreatment with PD98059, the inhibitor of ERK1/2, but not SB203580 or SP600125, almost completely blocks the effect exerted by HET0016. Exogenous 20-hydroxyeicosatetraenoic acid administration exerts opposite effects
N-methylsulfonyl-12, 12-dibromododec-11-enamide
-
a selective CYP omega-hydroxylase inhibitor, significantly inhibits myocardial apoptosis
N-methylsulfonyl-12,12-dibromododec-11-enamide
n-nonane
-
0.1% (v/v)
n-octane
-
0.1% (v/v)
n-pentane
-
0.1% (v/v)
octyl glucose neopentyl glycol
-
-
p-chloromercuribenzoate
-
0.1 mM concentration, 51% inhibition
propane
-
inhibits oxidation of methyl tert-butyl ether
propionate
-
0.01 mM, strong inhibition
retinoic acid
-
0.005 mM, 56% reduction of activity
additional information
-