1.14.15.18: calcidiol 1-monooxygenase
This is an abbreviated version!
For detailed information about calcidiol 1-monooxygenase, go to the full flat file.
Word Map on EC 1.14.15.18
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1.14.15.18
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1,25-dihydroxyvitamin
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cyp24a1
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parathyroid
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calcitriol
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rickets
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24-hydroxylase
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phosphorus
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hypercalcemia
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osteoblast
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d-dependent
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extrarenal
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autocrine
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hyperparathyroidism
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1alpha,25oh2d3
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hypophosphatemic
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osteomalacia
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klotho
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d-deficient
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24-ohase
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d-related
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hydroxylases
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vdr-mediated
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phosphaturic
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1,25-dihydroxycholecalciferol
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hyperphosphatemia
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secosteroids
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factor-23
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25-hydroxylation
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cathelicidin
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hypocalcemic
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calcemic
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intracrine
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prodifferentiating
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d3-24-hydroxylase
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sodium-phosphate
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7-dehydrocholesterol
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medicine
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d-binding
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casrs
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hypercalciuria
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hypovitaminosis
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calbindin-d9k
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vdres
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non-renal
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megalin
- 1.14.15.18
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1,25-dihydroxyvitamin
- cyp24a1
- parathyroid
- calcitriol
- rickets
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24-hydroxylase
- phosphorus
- hypercalcemia
- osteoblast
-
d-dependent
-
extrarenal
-
autocrine
- hyperparathyroidism
-
1alpha,25oh2d3
-
hypophosphatemic
- osteomalacia
- klotho
-
d-deficient
- 24-ohase
-
d-related
- hydroxylases
-
vdr-mediated
-
phosphaturic
- 1,25-dihydroxycholecalciferol
- hyperphosphatemia
-
secosteroids
-
factor-23
-
25-hydroxylation
- cathelicidin
-
hypocalcemic
-
calcemic
-
intracrine
-
prodifferentiating
-
d3-24-hydroxylase
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sodium-phosphate
- 7-dehydrocholesterol
- medicine
-
d-binding
-
casrs
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hypercalciuria
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hypovitaminosis
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calbindin-d9k
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vdres
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non-renal
-
megalin
Reaction
Synonyms
1-hydroxylase-25-hydroxyvitamin D3, 1-OHase, 1alpha,25-dihydroxyvitamin D hydroxylase, 1alpha-hydroxylase, 1alpha-OHase, 1alphaOHase, 25 hydroxy-vitamin D3-1alpha hydroxylase, 25(OH)VD3 1alpha-hydroxylase, 25-hydroxy D3-1alpha-hydroxylase, 25-hydroxycholecalciferol 1-hydroxylase, 25-hydroxycholecalciferol 1-monooxygenase, 25-hydroxycholecalciferol 1alpha-hydroxylase, 25-hydroxycholecalciferol-1-hydroxylase, 25-hydroxyvitamin D 1alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha-hydroxylase, 25-hydroxyvitamin D-1-alpha-hydroxylase, 25-hydroxyvitamin D-1alpha-hydroxylase, 25-hydroxyvitamin D3 1alpha-hydroxylase, 25-hydroxyvitamin D3-1alpha-hydroxylase, 25-hydroxyvitamin-D3-1alpha-hydroxylase, CYB27B1, CYP1alpha, CYP27A, CYP27B1, cytochrome P450 25-hydroxyvitamin D3-1alpha-hydroxylase, EC 1.14.13.13, extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase, extra-renal 25-hydroxyvitamin D3 1alpha-hydroxylase, hydroxylase, 25-hydroxcholecalciferol 1-, More, oxygenase, 25-hydroxycholecalciferol 1-mono-, P450 cytochrome 25-hydroxyvitamin D3 1alpha-hydroxylase, VD3 25-hydroxylase, VDH, vitamin D 1alpha-hydroxylase, vitamin D hydroxylase, vitamin D3 25- and 1alpha-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase, [25(OH)D3]-1alpha-hydroxylase
ECTree
1.14.15.18 calcidiol 1-monooxygenaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 1.14.15.18 - calcidiol 1-monooxygenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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renal distal tubular epithelial cell line. CYP27B1 gene expression is unchanged after treatement with parathyroid hormone or after high Ca2+ exposure
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expression of 1alpha-OHase is 1.25fold higher in MCF-7 compared to MCF-10A cells. In MCF-10A cells, at least 6 splice variants are detected. Alternative splicing of 1alpha-OHase can regulate the level of active enzyme
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renal proximal tubular epithelial cell line. CYP27B1 gene expression is elevated in response to parathyroid hormone. High Ca2+ exposure represses CYP27B1 gene expression in both dose and time-dependent fashion
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1-OHase mRNA expression is highest in pre-menopausal women and is increased by all hormones tested. In post-menopausal osteoblasts all hormones except biochainin A and genistein increase 1-OHase mRNA expressions to less extent. In male-derived osteoblasts only dihydrotestosterone and carboxybiochainin A increase 1-OHase mRNA expression
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high enzyme and vitamin D receptor expression level, especially in regions of lymphocyte infiltration
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prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription
additional information
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parathyroid hormone increases CYP1alpha mRNA and protein in a time-dependent manner. H2O2 inhibits parathyroid hormone-stimulated CYP1alpha protein levels and 1,25(OH)2D production in a dose dependent manner. The catalytic activity of the CYP1alpha protein may be reduced by free radical damage in CYP27B1 cells
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enzyme expression analysis in different samples of women with and without breast cancer, no correlation with breast cancer development
the enzyme expression is reduced in breast cancer cell specimen compared to healthy breast tissue
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intestinal cell line, both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation
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healthy and malignant, high expression level, 1alpha-hydroxylase is present at equal high levels in normal colonic epithelium as in ACFs, polyps, and colorectal cancer irrespective of tumor cell differentiation
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prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription
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RT-PCR expression and immunohistochemic analysis, low CYP27B1 expression in the atrophic kidney, predominantly expressed in proximal tubules
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prostate cancer cell line, greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase due to decreased RNA transcription
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epidermal growth factor does not upregulate 1alpha-OHase promoter activity in the carcinogenic prostate cells. Dysregulation of 1alpha-OHase in cancer cells may lead to the aberrant growth of prostate cancer cells
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expression of 1alpha-hydroxylase is intimately associated with toll-like receptor, TLR, recognition of pathogens in macrophages
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expression of 1alpha-OHase is 1.25fold higher in MCF-7 compared to MCF-10A cells. MCF-7 cells show no or marginal expression levels of splice variants
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tissue obtained from normal prostate, benign prostatic hyperplastia or cancer, primary and cultured prostate cancer cells have greatly decreased activity of 25-hydroxyvitamin D-1alpha-hydroxylase and are therefore resistant to the tumor suppressing activity of circulating 25-hydroxyvitamin D3
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epidermal growth factor upregulates 1alpha-OHase promoter activity in the noncarcinogenic prostate cells
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the enzyme is up-regulated by suberoylanilide hydroxamic acid, a histone deacetylase inhibitor
additional information
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altered expression of 1alpha-hydroxylase in different types of neoplasm including breast, prostate and colon cancers, autocrine/paracrine synthesis of 1,25(OH)2D3 is decreased in tumor cells and cell lines
additional information
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both 1alpha-hydroxylase and vitaminD receptor levels are negligible in tumor cells metastasizing to regional lymph nodes
additional information
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tissue-specific expression analysis, colonic and renal vitamin D hydroxylases are regulated independently, while low dietary calcium does not affect colonic expression of vitamin D receptor, VDR, or 25-hydroxyvitamin D3 1alpha-hydroxylase, it influences their renal expression by elevating CYP27B1 expression and reducing VDR and 25-hydroxyvitamin D3 24-hydroxylase expression, overview
additional information
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25OHD action involves localized extrarenal conversion to 1,25-dihydroxyvitamin D via tissue-specific expression of the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase
additional information
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no truncated enzyme form in lung, testis, heart, or brain mitochondria
