1.14.15.16: vitamin D3 24-hydroxylase
This is an abbreviated version!
For detailed information about vitamin D3 24-hydroxylase, go to the full flat file.
Word Map on EC 1.14.15.16
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1.14.15.16
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cyp24a1
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parathyroid
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1alpha-hydroxylase
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rickets
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24,25-dihydroxyvitamin
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hypercalcemia
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24-hydroxylation
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retinoids
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d-dependent
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1alpha,25oh2d3
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osteocalcin
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vdres
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d-deficient
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1-hydroxylase
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d-responsive
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1,25-dihydroxycholecalciferol
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hyperparathyroidism
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ketoconazole
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nephrocalcinosis
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alopecia
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vdr-mediated
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hypophosphatemic
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d-binding
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1,25oh2d3-induced
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extrarenal
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hypercalciuria
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cholecalciferol
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25-hydroxycholecalciferol
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calcemic
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1alpha-ohase
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alpha-hydroxyvitamin
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calcidiol
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d-resistant
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d3-1alpha-hydroxylase
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osteomalacia
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d-replete
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secosteroid
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hvdrr
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sodium-phosphate
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medicine
- 1.14.15.16
- cyp24a1
- parathyroid
-
1alpha-hydroxylase
- rickets
-
24,25-dihydroxyvitamin
- hypercalcemia
-
24-hydroxylation
-
retinoids
-
d-dependent
-
1alpha,25oh2d3
- osteocalcin
-
vdres
-
d-deficient
- 1-hydroxylase
-
d-responsive
- 1,25-dihydroxycholecalciferol
- hyperparathyroidism
- ketoconazole
- nephrocalcinosis
- alopecia
-
vdr-mediated
-
hypophosphatemic
-
d-binding
-
1,25oh2d3-induced
-
extrarenal
-
hypercalciuria
- cholecalciferol
- 25-hydroxycholecalciferol
-
calcemic
- 1alpha-ohase
-
alpha-hydroxyvitamin
- calcidiol
-
d-resistant
-
d3-1alpha-hydroxylase
-
osteomalacia
-
d-replete
-
secosteroid
-
hvdrr
-
sodium-phosphate
- medicine
Reaction
Synonyms
1,25-(OH)2D3-24-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase, 1alpha,25-dihydroxyvitamin D3 24-hydroxylase, 24-hydroxylase, 24-OHase, 24OHase, 25-hydroxyvitamin D-24-hydroxylase, 25-hydroxyvitamin D3-24-hydroxylase, 25-OH-D3-24-hydroxylase, CYP24A1, cytochrome P450 24A1, EC 1.14.13.126, P450cc24, vitamin D 24-hydroxylase, vitamin D-24-hydroxylase
ECTree
1.14.15.16 vitamin D3 24-hydroxylaseAdvanced search results
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results (General Information
General Information on EC 1.14.15.16 - vitamin D3 24-hydroxylase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
malfunction
metabolism
physiological function
additional information
evaluation of the 3,5-dimethoxy and 3,4,5-trimethoxy derivatives of imidazole styrylbenzamide in chronic lymphocytic leukemia cells reveals that co-treatment of 1alpha,25-dihydroxyvitamin D3 plus inhibitor coordinately upregulates GADD45alpha and CDKN1A
malfunction
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the Cyp24a1 knockout mouse is consistent with a catabolic role for CYP24A1, because it shows poor viability, 50% of homozygous mice die before weaning, showing hypercalcemia and signs of renal calcification. Isolated cultured keratinocytes from Cyp24a1-deficient mice fail to synthesize calcitroic acid
malfunction
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natural inactivating mutations of CYP24A1 cause the genetic disease idiopathic infantile hypercalcemia
malfunction
mutations of the CYP24A1 gene encoding the 24-hydroxylase that inactivates metabolites of vitamin D can cause hypercalcemia in infants and adults, phenotypes, overview. A young adult with a CYP24A1 mutation L409S shows bilateral nephrolithiasis and hypercalcemia in the setting of excessive vitamin D intake
metabolism
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P450cc24 is a multicatalytic enzyme catalyzing most, if not all, of the reactions in the C-24/C-23 pathway of 25-hydroxyvitamin D3 (calcidiol) metabolism
metabolism
CYP24A1 proceeds mainly through the C-24 oxidation pathway, resulting in its conversion into a side-chain cleaved inactive water-soluble metabolite, calcitroic acid. Isolation and identification of 3-epi-calcitroic acid as the final inactive metabolite of 3-epi-1alpha,25(OH)2D3 produced by rat CYP24A1. The amount of 3-epi-calcitroic acid produced from 3-epi-1alpha,25(OH)2D3 is threefold less than that of calcitroic acid, the analogous final inactive metabolite produced from 1alpha,25(OH)2D3, due to a slower oxidation reaction with the epimer. Molecular docking analysis using the crystal structure of rat CYP24A1 reveals that 3-epi-1alpha,25(OH)2D3, unlike 1alpha,25(OH)2D3, binds to CYP24A1 in an alternate configuration that destabilizes the formation of the enzyme-substrate complex sufficiently to slow the rate at which 3-epi-1alpha,25(OH)2D3 is inactivated by CYP24A1 through its metabolism into 3-epi-calcitroic acid. Metabolism of 1alpha,25(OH)2D3 into 3-epi-1alpha,25(OH)2D3 through the C-3 epimerization pathway, overview
physiological function
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CYP24A1 can activate and inactivate vitamin D prodrugs in skin and other target cells in vitro
physiological function
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CYP24A1 can activate and inactivate vitamin D prodrugs in skin and other target cells in vitro
physiological function
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CYP24A1 has a crucial role in vitamin D inactivation in vivo
physiological function
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CYP24A1 has a crucial role in vitamin D inactivation in vivo
physiological function
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upregulated gene expression of CYP24A1 leads to a misbalance of vitamin D metabolites in clear cell renal cell carcinomas and thus contributing to its pathogenesis
physiological function
CYP24A1 is a multicatalytic enzyme that sequentially oxidizes the side chain of 1alpha,25-dihydroxyvitamin D3, leading to loss of its hormonal activity. 3-Epi-1alpha,25-dihydroxyvitamin D3 (3-epi-1alpha,25(OH)2D3), a natural metabolite of 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), exhibits potent vitamin D receptor-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion
physiological function
CYP24A1 is the multicatalytic cytochrome P450 responsible for the catabolism of vitamin D via the C23- and C24-oxidation pathways. CYP24A1 is a membrane-bound hemoprotein which utilizes the electrons from NADPH via a transport chain comprising adrenodoxin and adrenodoxin reductase. Inactivation of 1,25(OH)2D3 by CYP24A1 via the C24-oxidation pathway
physiological function
CYP24A1 is the multicatalytic cytochrome P450 responsible for the catabolism of vitamin D via the C23- and C24-oxidation pathways. CYP24A1 is a membrane-bound hemoprotein which utilizes the electrons from NADPH via a transport chain comprising adrenodoxin and adrenodoxin reductase. Inactivation of 1,25(OH)2D3 by CYP24A1 via the C24-oxidation pathway, overview
