1.14.15.15: cholestanetriol 26-monooxygenase

This is an abbreviated version!
For detailed information about cholestanetriol 26-monooxygenase, go to the full flat file.

Word Map on EC 1.14.15.15

1.14.15.15

bile

xanthomatosis

cerebrotendinous

27-hydroxycholesterol

chenodeoxycholic

cholestanol

tendon

xanthomas

oxysterols

cataract

cyp7a1

27-hydroxylation

cholic

12alpha-hydroxylase

cholecalciferol

lipid-storage

lxralpha

7alpha-hydroxylated

cholestyramine

7-ketocholesterol

7alpha-hydroxy-4-cholesten-3-one

alpha-hydroxyvitamin

medicine

lithogenic

Reaction

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al

+ 2 reduced adrenodoxin + 2 H+ +

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate

+ 2 oxidized adrenodoxin +

Synonyms

5beta-cholestane-3 alpha,7alpha,12alpha,26-tetrol dehydrogenase, 5beta-cholestane-3 alpha,7alpha,12alpha-triol-26-al oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase, 5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase, cholestanetriol 26-hydroxylase, cholestanetriol 27-hydroxylase, cholesterol C-26 hydroxylase, cholesterol hydroxylase, CYP125A4, CYP27, CYP27A, CYP27A1, cytochrome P-450 sterol 26-hydroxylase, cytochrome P-450A, cytochrome P450 125A4, cytochrome P450 27A, cytochrome P450c27, dehydrogenase, cholestanetetrol 26-, EC 1.1.1.161, EC 1.14.13.15, EC 1.2.1.40, hydroxylase, 5beta-cholestane-3alpha,7alpha,12alpha-triol, More, oxygenase, cholestanetriol 26-mono-, P450 27A1, sterol 27-hydroxylase, TEHC-NAD oxidoreductase, vitamin D3 25-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.15 cholestanetriol 26-monooxygenase

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Results	in table
3	Activating Compound
146	AA Sequence
3	Application
2	CAS Registry Number
13	Cloned(Commentary)
31	Cofactor
384	Disease/ Diagnostics
4	Expression
22	General Information
23	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
9	KM Value [mM]
30	Localization
1	Metals/Ions
5	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
40	Organism
4	Pathway
5	PDB ID
9	pH Optimum
2	pH Range
2	Posttranslational Modification
20	Protein Variants
12	Purification (Commentary)
5	Reaction
3	Reaction Type
40	Reference
69	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
73	Substrates and Products (Substrate)
4	Subunits
54	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
10	Turnover Number [1/s]

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Cloned on EC 1.14.15.15 - cholestanetriol 26-monooxygenase

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Rattus norvegicus

439035, 439036

CYP27 expression analysis in the brain

Rattus norvegicus

705935

DNA and amino acid sequence determinationa nd analysis, functional expression in COS-M6 cells, overview

Oryctolagus cuniculus

674400

expression analysis

Homo sapiens

703582

expression of wild-type and mutant enzymes in Escherichia coli

Homo sapiens

671957

gene CYP27A1, cloned from liver cDNA, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis

Macaca fascicularis

B8K1T2

736710

gene CYP27A1, DNA and amino acid sequence determination and analysis, genotyping, overview

2 entries

gene CYP27A1, DNA and amino acid sequence determination and genomic analysis, genotyping

Homo sapiens

713175

gene CYP27A1, quantitative real-time PCR enzyme expression analysis

2 entries

gene CYP27A1, recombinant expression of His-tagged enzyme in Bacillus megaterium

Homo sapiens

Q02318

735739