1.14.15.11: pentalenic acid synthase

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For detailed information about pentalenic acid synthase, go to the full flat file.

Word Map on EC 1.14.15.11

1.14.15.11

avermitilis

daidzein

ferredoxins

diclofenac

monooxygenases

phenobarbital

hydroxylase

compactin

putidaredoxin

naringenin

3\'-hydroxylase

3'-position

host-plant

isoquinoline

substrate-promiscuous

isoflavone

regiospecific

insecticides

Reaction

Synonyms

CYP105D7, CYP28, pentalenic acid synthase, sav7469, SAV_7469

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.15.11 pentalenic acid synthase

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Results	in table
127	AA Sequence
3	Cloned(Commentary)
1	Cofactor
2	Crystallization (Commentary)
1	General Information
2	kcat/KM [mM/s]
4	KM Value [mM]
9	Organism
3	Pathway
1	PDB ID
1	pH Optimum
1	Reaction
7	Reference
14	Substrates and Products (Substrate)
4	Subunits
14	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

General Information

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General Information on EC 1.14.15.11 - pentalenic acid synthase

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physiological function

Streptomyces avermitilis

Q825I8

disruption of the sav7469 gene encoding pentalenic acid synthase abolishes production of pentalenic acid. The deletion mutant accumulates 1-deoxypentalenic acid. Recombinant enzyme prepared from Escherichia coli catalyzes the oxidative conversion of 1-deoxypentalenic acid to pentalenic acid in the presence of the electron-transport partners, ferredoxin and ferredoxin reductase, both in vivo and in vitro

719674