1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase
This is an abbreviated version!
For detailed information about 4-hydroxyphenylacetate 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.14.9
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1.14.14.9
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flavin
-
3,4-dihydroxyphenylacetate
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baumannii
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flavin-dependent
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tyrosol
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hydroxytyrosol
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fmnh
-
two-protein
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piceatannol
-
synthesis
- 1.14.14.9
- flavin
- 3,4-dihydroxyphenylacetate
- baumannii
-
flavin-dependent
- tyrosol
- hydroxytyrosol
- fmnh
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two-protein
- piceatannol
- synthesis
Reaction
Synonyms
4 HPA 3-hydroxyylase, 4-HPA hydroxylase, 4-hydroxyphenylacetate 3-hydroxylase, 4-hydroxyphenylacetic acid 3-hydroxylase, 4HPA 3-monooxygenase, 4HPA3H, C2-hpah, EC 1.14.13.3, HPA 3-hydroxylase, HpaB, hpaBC, HpaC, HPAH, More, p-hydroxyphenylacetate 3-hydroxylase, p-hydroxyphenylacetate hydroxylase, p-hydroxyphenylacetic 3-hydroxylase, TPY_2462, two-component p-hydroxyphenylacetate hydroxylase
ECTree
1.14.14.9 4-hydroxyphenylacetate 3-monooxygenaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.14.14.9 - 4-hydroxyphenylacetate 3-monooxygenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxyphenylacetate + FMNH2 + O2
3,4-dihydroxyphenylacetate + FMN + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FADH2 + O2
3,4-dihydroxyphenylacetate + FAD + H2O
-
4.3 mM 4-hydroxyphenylacetate is converted within 1 h
-
-
?
4-hydroxyphenylacetate + FMNH + O2
3,4-dihydroxyphenylacetate + FMN + H2O
-
-
-
-
?
4-hydroxyphenylacetate + FMNH + O2
3,4-dihydroxyphenylacetate + FMN + H2O
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
?
4-hydroxyphenylacetate + NAD(P)H + H+ + O2
3,4-dihydroxyphenylacetate + NAD(P)+ + H2O
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
via C2-FMNH-, and C4a-hydroperoxy-FMN and C4a-hydroxy-FMN
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + H+ + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
high substrate specificity
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
biodegradation of aromatic compounds
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of tyrosine with 3,4-dihydroxyphenylacetate as key intermediate
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of tyrosine with 3,4-dihydroxyphenylacetate as key intermediate
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
initial reaction in the degradation of 4-hydroxyphenylacetate
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
inducible chromosomally encoded meta-cleavage pathway of aromatic degradation
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
4-hydroxyphenylacetic acid degradative pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
first enzyme in 4-hydroxyphenylacetate metabolism
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
Escherichia coli B / ATCC 11303
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradative pathway involved in the assimilation of different aromatic compounds
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
key enzyme in pathway of degradation of phenylalanine, tyrosine and other aromatic amines
-
?
4-hydroxyphenylacetate + NADH + O2
3,4-dihydroxyphenylacetate + NAD+ + H2O
-
degradation of 4-hydroxyphenylacetate by inducible meta-cleavage pathway
-
?
4-hydroxyphenylacetate + NADPH + H+ + O2
3,4-dihydroxyphenylacetate + NADP+ + H2O
-
-
-
?
4-hydroxyphenylacetate + NADPH + H+ + O2
3,4-dihydroxyphenylacetate + NADP+ + H2O
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
?
additional information
?
-
-
the enzyme is a flavin-dependent two-component monooxygenase that consists of a reductase component and an oxygenase component C2. C2 catalyzes the hydroxylation of HPA using oxygen and reduced FMN as co-substrates. All flavin-dependent monooxygenases perform oxygenation through the participation of a reactive intermediate, C4a-hydroperoxy-flavin
-
-
?
additional information
?
-
the enzyme is a flavin-dependent two-component monooxygenase that consists of a reductase component and an oxygenase component C2. C2 catalyzes the hydroxylation of HPA using oxygen and reduced FMN as co-substrates. All flavin-dependent monooxygenases perform oxygenation through the participation of a reactive intermediate, C4a-hydroperoxy-flavin
-
-
?
additional information
?
-
-
the enzyme utilizes the C-terminal domain of the reductase component as an autoinhibitory domain to suppress both the rate of reduction of FMN and the rate of release of FMNH2 from the reductase component
-
-
?
additional information
?
-
-
the enzyme does not form stable complexes or channel substrates with the NAD(P)H-flavin oxidoredctase HpaC, but NAD(P)H-flavin oxidoreductase HpaC is required for delivering of sufficient amounts of FADH2
-
-
?
additional information
?
-
the oxygenase HpaB is a component of the 4-hydroxyphenylacetate 3-monooxygenase enzyme that is responsible for the hydroxylation of 4-hydroxyphenylacetate. It utilizes molecular oxygen and a reduced flavin, which is provided by HpaC, the second component of the enzyme
-
-
?
additional information
?
-
-
the oxygenase HpaB is a component of the 4-hydroxyphenylacetate 3-monooxygenase enzyme that is responsible for the hydroxylation of 4-hydroxyphenylacetate. It utilizes molecular oxygen and a reduced flavin, which is provided by HpaC, the second component of the enzyme
-
-
?
additional information
?
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
the oxygenase HpaB is a component of the 4-hydroxyphenylacetate 3-monooxygenase enzyme that is responsible for the hydroxylation of 4-hydroxyphenylacetate. It utilizes molecular oxygen and a reduced flavin, which is provided by HpaC, the second component of the enzyme
-
-
?
