1.14.14.29: 25/26-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 25/26-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Reaction

Synonyms

25-hydroxycholesterol 7alpha-hydroxylase, 25-hydroxycholesterol 7alpha-monooxygenase, 25-hydroxycholesterol-7alpha-hydroxylase, cholesterol 25-hydroxylase, Cyp39a1, CYP7B, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase, CYPB1, cytochome P450 7B1, cytochrome P-450 oxysterol 7-alpha-hydroxylase, EC 1.14.13.100, EC 1.14.13.60, oxysterol 7 alpha-hydroxylase, oxysterol 7alpha-hydroxylase, oxysterol-7alpha-hydroxylase, Steroid hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.29 25/26-hydroxycholesterol 7alpha-hydroxylase

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Results	in table
1	Activating Compound
4	AA Sequence
1	Application
2	CAS Registry Number
6	Cloned(Commentary)
19	Cofactor
391	Disease/ Diagnostics
3	Expression
8	General Information
13	Inhibitors
2	Ki Value [mM]
7	KM Value [mM]
8	Localization
2	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
31	Organism
2	Pathway
8	Protein Variants
4	Reaction
3	Reaction Type
30	Reference
38	Source Tissue
46	Substrates and Products (Substrate)
2	Subunits
45	Synonyms
1	Systematic Name
2	Turnover Number [1/s]

Engineering

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Engineering on EC 1.14.14.29 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

A316AA

Homo sapiens

-

the mutation is associated with the SPG5A subtype of hereditary spastic paraplegia

726643

G147D

Homo sapiens

-

the mutation is associated with the SPG5A subtype of hereditary spastic paraplegia

726643

G443A

Homo sapiens

O75881

c.1328G-C, naturally occuring mutation of CYP7B1 involved in spastic paraplegia type 5

711775

G87V

Homo sapiens

O75881

c.260G-T, naturally occuring mutation of CYP7B1 involved in spastic paraplegia type 5

711775

H285L

Homo sapiens

O75881

c.854A-T, naturally occuring mutation of CYP7B1 involved in spastic paraplegia type 5

711775

R112X

Homo sapiens

-

the mutation is associated with the SPG5A subtype of hereditary spastic paraplegia

726643

R324H

Homo sapiens

O75881

c.971G-A, naturally occuring mutation of CYP7B1 involved in spastic paraplegia type 5

711775

R486C

Homo sapiens

-

the mutation is associated with the SPG5A subtype of hereditary spastic paraplegia

726643