1.14.14.26: 24-hydroxycholesterol 7alpha-hydroxylase

This is an abbreviated version!
For detailed information about 24-hydroxycholesterol 7alpha-hydroxylase, go to the full flat file.

Reaction

Synonyms

24-hydroxycholesterol 7alpha-monooxygenase, Cyp39a1, CYP39A1 oxysterol 7alpha-hydroxylase, EC 1.14.13.99, oxysterol 7alpha-hydroxylase CYP39A1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.26 24-hydroxycholesterol 7alpha-hydroxylase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
18	AA Sequence
2	CAS Registry Number
2	Cloned(Commentary)
1	Cofactor
36	Disease/ Diagnostics
1	Molecular Weight [Da]
3	Organism
1	Pathway
1	Reaction
3	Reaction Type
3	Reference
4	Source Tissue
3	Substrates and Products (Substrate)
1	Subunits
9	Synonyms
1	Systematic Name

Systematic Name

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Systematic Name on EC 1.14.14.26 - 24-hydroxycholesterol 7alpha-hydroxylase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Systematic Name Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SYSTEMATIC NAME

IUBMB Comments

(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)

A P-450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium [2]. The enzyme is specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.