1.14.14.24: vitamin D 25-hydroxylase

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For detailed information about vitamin D 25-hydroxylase, go to the full flat file.

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Synonyms

CYP2R1, CYP24A1, CYP2C11, CYP2D25, CYP2J3, CYP2R1, CYPIIJ3, Cytochrome P450 2C11, cytochrome P450 2J2, Cytochrome P450 2J3, cytochrome P450 2R1, EC 1.14.13.159, VDH, vitamin D 25-hydroxylase, vitamin D-25-hydroxylase, vitamin D2 25-hydroxylase, vitamin D3 25-hydroxylase, vitamin D3 hydroxylase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.24 vitamin D 25-hydroxylase

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Results	in table
5	Activating Compound
8	AA Sequence
5	Application
13	Cloned(Commentary)
14	Cofactor
2	Crystallization (Commentary)
606	Disease/ Diagnostics
5	Expression
12	General Information
4	Inhibitors
22	KM Value [mM]
16	Localization
1	Metals/Ions
5	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
26	Organism
6	Pathway
3	pH Optimum
18	Protein Variants
2	Purification (Commentary)
1	Reaction
26	Reference
26	Source Tissue
1	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
6	Subunits
36	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
13	Turnover Number [1/s]

Expression

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Expression on EC 1.14.14.24 - vitamin D 25-hydroxylase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

1alpha,25-dihydroxyvitamin D3 increases CYP2R1 gene and and vitamin D receptor mRNA expression in human oral squamous cell carcinoma tumor cells. JNK inhibitor suppresses 1,25 (OH)2D3 stimulation of hCYP2R1 gene promoter activity compared to unstimulated cells

Homo sapiens

Q6VVX0

736222

CYP2J3 mRNA is is expressed at a level similar to that of CYP27A1 without marked sexual dimorphism

Rattus norvegicus

P51590

717769

genes CYP2R1 encoding vitamin D 25-hydroxylase, CYP27B1 encoding 25-hydroxyvitamin D-1 alpha hydroxylase and CYP24A1 encoding 1,25-dihydroxyvitamin D(3) 24-hydroxylase are upregulated in clear cell renal cell carcinomas compared with normal tissue. CYP24A1 displays a significantly higher expression in tumours than CYP27B1 and CYP2R1, whereas no differences in the expression of these genes are found in healthy renal tissue

Homo sapiens

Q6VVX0

724907

in male rats, hepatic microsomal CYP2C11 mRNA is decreased by 73% upon hypophysectomy

Rattus norvegicus

P08683

717071

the luteinizing hormone induces the enzyme. MA-10 cell stimulation with either human chorionic gonadotropin or uncarboxylated-osteocalcin increases CYP2R1 protein expression in a dose-dependent manner and, in turn, increases the release of 25-hydroxy-vitamin D in culture medium. Osteocalcin, in particular uncarboxylated osteocalcin, stimulates 25-hydroxylation of vitamin D in Leydig cells through a direct effect on the expression of the main actor in the 25-hydroxylase activity of vitamin D, the CYP2R1 protein

Mus musculus

Q6VVW9

736019