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1.14.14.23: cholesterol 7alpha-monooxygenase

This is an abbreviated version!
For detailed information about cholesterol 7alpha-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.23

Reaction

cholesterol
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
7alpha-hydroxycholesterol
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

7alpha-hydroxylase, bile acid-synthetic enzyme, C7alphaOH, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha hydroxylase, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, cholesterol 7a-hydroxylase, cholesterol 7alpha hydroxylase, cholesterol 7alpha-hydroxylase, cholesterol-NADPH oxidoreductase, 7alpha-hydroxylating, CYP125A4, CYP7A, CYP7A1, Cyp7alpha1, CYPVII, cytochrome P450 125A4, EC 1.14.13.17, hepatic cholesterol 7alpha-hydroxylase, More, oxygenase, cholesterol 7alpha-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.23 cholesterol 7alpha-monooxygenase

Specific Activity

Specific Activity on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000034
wild-type Hep-G2 cell microsomes
0.000022
-
day 1 after hepatectomy
0.000048
-
day 1 after sham operation
0.000058
-
day 3 after sham operation
0.000065
-
day 3 after hepatectomy
0.000069
-
day 7 after hepatectomy
0.000075
-
day 7 after sham operation
0.000092
recombinant enzyme in transformed Hep-G2 cells
0.00015
-
-
0.0006
-
enzyme activity depends on circadian rhythm, minimum activity at 2 p.m.
0.00077
-
after incubation with 1 unit alkaline phosphatase for 30 min
0.00092
-
after incubation with 1 unit alkaline phosphatase for 30 min
0.001
-
enzyme activity depends on circadian rhythm, maximum activity at 10 p.m.
0.00196
-
-
0.00294
-
after incubation with 5 units cAMP-dependent protein kinase for 30 min
0.00315
-
after incubation with 5 units cAMP-dependent protein kinase for 30 min
additional information