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1.14.14.23: cholesterol 7alpha-monooxygenase

This is an abbreviated version!
For detailed information about cholesterol 7alpha-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.23

Reaction

cholesterol
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
7alpha-hydroxycholesterol
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

7alpha-hydroxylase, bile acid-synthetic enzyme, C7alphaOH, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha hydroxylase, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, cholesterol 7a-hydroxylase, cholesterol 7alpha hydroxylase, cholesterol 7alpha-hydroxylase, cholesterol-NADPH oxidoreductase, 7alpha-hydroxylating, CYP125A4, CYP7A, CYP7A1, Cyp7alpha1, CYPVII, cytochrome P450 125A4, EC 1.14.13.17, hepatic cholesterol 7alpha-hydroxylase, More, oxygenase, cholesterol 7alpha-mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.23 cholesterol 7alpha-monooxygenase

Reference

topprint

Reference on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mitton, J.R.; Scholan, N.A.; Boyd, G.S.
The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7-alpha-hydroxylase enzyme system
Eur. J. Biochem.
20
569-579
1971
Rattus norvegicus
Manually annotated by BRENDA team
Boyd, G.S.; Grimwade, A.M.; Lawson, M.E.
Studies on rat-liver microsomal cholesterol 7alpha-hydroxylase
Eur. J. Biochem.
37
334-340
1973
Rattus norvegicus
Manually annotated by BRENDA team
Rush, W.R.; Gibson, G.G.; Parke, D.V.
The purification and reconstitution of cytochrome P-450-dependent cholesterol 7alpha-hydroxylase activity from rat liver microsomal fractions
Biochem. Soc. Trans.
8
102-103
1980
Rattus norvegicus
Manually annotated by BRENDA team
Van Cantfort, J.; Gielen, J.
Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro
Eur. J. Biochem.
55
33-40
1975
Rattus norvegicus
Manually annotated by BRENDA team
Andersson, S.; Boström, H.; Danielsson, H.; Wikvall, K.
Purification from rabbit and rat liver of cytochromes P-450 involved in bile acid biosynthesis
Methods Enzymol.
111
364-377
1985
Rattus norvegicus
Manually annotated by BRENDA team
Erickson, S.K.; Bösterling, B.
Cholesterol 7alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles
J. Lipid Res.
22
872-876
1981
Homo sapiens
Manually annotated by BRENDA team
Nguyen, L.B.; Shefer, S.; Salen, G.; Ness, G.; Tanaka, R.D.; Packin, V.; Thomas, P.; Shore, V.; Batta, A.
Purification of cholesterol 7alpha-hydroxylase from human and rat liver and production of inhibiting polyclonal antibodies
J. Biol. Chem.
265
4541-4546
1990
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kalles, I.; Wikvall, K.
Role of sulfhydryl groups in catalytic activity of purified cholesterol 7alpha-hydroxylase system from rabbit and rat liver microsomes
Biochem. Biophys. Res. Commun.
100
1361-1369
1981
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Waxman, D.J.
Rat hepatic cholesterol 7alpha-hydroxylase: biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes
Arch. Biochem. Biophys.
247
335-345
1986
Rattus norvegicus
Manually annotated by BRENDA team
Chiang, J.Y.L.; Miller, W.F.; Lin, G.M.
Regulation of cholesterol 7alpha-hydroxylase in the liver. Purification of cholesterol 7alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7alpha-hydroxylase by cholestyramine and circadian rhythm
J. Biol. Chem.
265
3889-3897
1990
Rattus norvegicus
Manually annotated by BRENDA team
Suckling, K.E.; Jackson, B.; Suffolk, R.A.; Houghton, J.D.; Suckling, C.J.
Effects of 6,6-difluorocholestanol and 7,7-difluorocholestanol on hepatic enzymes of cholesterol metabolism
Biochim. Biophys. Acta
1002
401-404
1989
Rattus norvegicus
Manually annotated by BRENDA team
Ogishima, T.; Deguchi, S.; Okuda, K.
Purification and characterization of cholesterol 7alpha-hydroxylase from rat liver microsomes
J. Biol. Chem.
262
7646-7650
1987
Rattus norvegicus
Manually annotated by BRENDA team
Danielsson, H.; Kalles, I.; Wikvall, K.
Regulation of hydroxylations in biosynthesis of bile acids. Isolation of a protein from rat liver cytosol stimulating reconstituted cholesterol 7alpha-hydroxylase activity
J. Biol. Chem.
259
4258-4262
1984
Rattus norvegicus
Manually annotated by BRENDA team
Ozasa, S.; Boyd, G.S.
Cholesterol 7alpha-hydroxylase of rat liver. Studies on the solubilisation, resolution and reconstitution of the enzyme complex
Eur. J. Biochem.
119
263-272
1981
Rattus norvegicus
Manually annotated by BRENDA team
Hansson, R.; Wikvall, K.
Properties of reconstituted cholesterol 7alpha-hydroxylase system from rat and rabbit liver microsomes
Eur. J. Biochem.
93
419-426
1979
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Miki, N.; Miura, R.; Miyake, Y.
Purification and characterization of cholesterol 7alpha-hydroxylase cytochrome P-450 of untreated rabbit liver microsomes
J. Biochem.
101
1087-1094
1987
Oryctolagus cuniculus
Manually annotated by BRENDA team
Nguyen, L.B.; Shefer, S.; Salen, G.; Chiang, J.Y.L.; Patel, M.
Cholesterol 7alpha-hydroxylase activities from human and rat liver are modulated in vitro posttranslationally by phosphorylation/dephosphorylation
Hepatology
24
1468-1474
1996
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Souidi, M.; Parquet, M.; Ferezou, J.; Lutton, C.
Modulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase activities by steroids and physiological conditions in hamster
Life Sci.
17
1585-1593
1999
Mesocricetus auratus
Manually annotated by BRENDA team
Yamada, M.; Nagatomo, J.; Setoguchi, Y.; Kuroki, N.; Higashi, s.; Setoguchi, T.
Circadian Rhytms of sterol 12alpha-hydroxylase, cholesterol 7alpha-hydroxylase and DBP involved in rat cholesterol catabolism
Biol. Chem.
381
1149-1153
2000
Rattus norvegicus
Manually annotated by BRENDA team
Galman, C.; Arvidsson, I.; Angelin, B.; Rudling, M.
Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood
J. Lipid Res.
44
859-866
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kinowaki, M.; Tanaka, S.; Maeda, Y.; Higashi, S.; Okuda, K.; Setoguchi, T.
Half-life of cholesterol 7alpha-hydroxylase activity and enzyme mass differ in animals and humans when determined by a monoclonal antibody against human cholesterol 7alpha-hydroxylase
J. Steroid Biochem. Mol. Biol.
81
377-380
2002
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Tanaka, S.; Kinowaki, M.; Eto, T.A.; Ota, Y.; Maeda, Y.; Okuda, K.; Setoguchi, T.; Chijiiwa, K.
Sulfhydryl groups responsible for extreme lability of human cholesterol 7alpha-hydroxylase identified by site-directed mutagenesis
J. Steroid Biochem. Mol. Biol.
86
35-40
2003
Cricetulus griseus, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Tiemann, M.; Han, Z.; Soccio, R.; Bollineni, J.; Shefer, S.; Sehayek, E.; Breslow, J.L.
Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity
Proc. Natl. Acad. Sci. USA
101
1846-1851
2004
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Shin, Y.; Vaziri, N.D.; Willekes, N.; Kim, C.H.; Joles, J.A.
Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia
Am. J. Physiol. Endocrinol. Metab.
289
E993-E998
2005
Rattus norvegicus
Manually annotated by BRENDA team
Maeda, Y.; Nagatomo, H.; Kuroki, N.; Nagatomo, J.; Uchiyama, F.; Shimozono, K.; Kohno, Y.; Chijiiwa, K.
Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats
Ann. Clin. Lab. Sci.
35
323-328
2005
Rattus norvegicus
Manually annotated by BRENDA team
Handschin, C.; Gnerre, C.; Fraser, D.J.; Martinez-Jimenez, C.; Jover, R.; Meyer, U.A.
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids
Arch. Biochem. Biophys.
434
75-85
2005
Gallus gallus (Q5ILH2), Gallus gallus
Manually annotated by BRENDA team
Abrahamsson, A.; Krapivner, S.; Gustafsson, U.; Muhrbeck, O.; Eggertsen, G.; Johansson, I.; Persson, I.; Angelin, B.; Ingelman-Sundberg, M.; Bjoerkhem, I.; Einarsson, C.; vant Hooft, F.M.
Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration
Atherosclerosis
182
37-45
2005
Homo sapiens
Manually annotated by BRENDA team
Stroup, D.; Ramsaran, J.R.
Cholesterol 7alpha-hydroxylase is phosphorylated at multiple amino acids
Biochem. Biophys. Res. Commun.
329
957-965
2005
Homo sapiens (P22680), Homo sapiens
Manually annotated by BRENDA team
Charoenteeraboon, J.; Nithipatikom, K.; Campbell, W.B.; Piyachaturawat, P.; Wilairat, P.; Rongnoparut, P.
Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone
Eur. J. Pharmacol.
515
43-46
2005
Homo sapiens
Manually annotated by BRENDA team
Wang, J.; Olin, M.; Rozell, B.; Bjoerkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse
Histochem. Cell Biol.
127
253-261
2007
Mus musculus
Manually annotated by BRENDA team
Li, T.; Kong, X.; Owsley, E.; Ellis, E.; Strom, S.; Chiang, J.Y.
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c
J. Biol. Chem.
281
28745-28754
2006
Homo sapiens (P22680), Homo sapiens
Manually annotated by BRENDA team
Hubacek, J.A.; Bobkova, D.
Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering
Mol. Diagn. Ther.
10
93-100
2006
Homo sapiens (P22680)
Manually annotated by BRENDA team
Shibata, S.; Hayakawa, K.; Egashira, Y.; Sanada, H.
Hypocholesterolemic mechanism of Chlorella: Chlorella and its indigestible fraction enhance hepatic cholesterol catabolism through up-regulation of cholesterol 7alpha-hydroxylase in rats
Biosci. Biotechnol. Biochem.
71
916-925
2007
Rattus norvegicus
Manually annotated by BRENDA team
Lee, M.S.; Park, J.Y.; Freake, H.; Kwun, I.S.; Kim, Y.
Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells
Br. J. Nutr.
99
1182-1185
2008
Homo sapiens
Manually annotated by BRENDA team
Hubacek, J.A.; Bobkova, D.; Bohuslavova, R.; Poledne, R.
Differences in expression of cholesterol 7alpha-hydroxylase between PHHC and Wistar rats
Folia Biol. (Praha)
54
18-23
2008
Rattus norvegicus
Manually annotated by BRENDA team
Mitro, N.; Godio, C.; De Fabiani, E.; Scotti, E.; Galmozzi, A.; Gilardi, F.; Caruso, D.; Chacon, A.B.; Crestani, M.
Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis
Hepatology
46
885-897
2007
Homo sapiens (P22680)
Manually annotated by BRENDA team
Cheng, Z.; Zhou, H.; Luther, M.; Yin, J.J.; Yu, L.L.
Effects of wheat antioxidants on oxygen diffusion-concentration products in liposomes and mRNA levels of HMG-CoA reductase and cholesterol 7alpha-hydroxylase in primary rat hepatocytes
J. Agric. Food Chem.
56
5033-5042
2008
Rattus norvegicus
Manually annotated by BRENDA team
Noshiro, M.; Usui, E.; Kawamoto, T.; Kubo, H.; Fujimoto, K.; Furukawa, M.; Honma, S.; Makishima, M.; Honma, K.; Kato, Y.
Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis
J. Biol. Rhythms
22
299-311
2007
Mus musculus (Q64505)
Manually annotated by BRENDA team
Li, T.; Ma, H.; Chiang, J.Y.
TGF{beta}1, TNF{alpha}, and insulin signaling crosstalk in regulation of the rat cholesterol 7{alpha}-hydroxylase gene expression
J. Lipid Res.
49
1981-1989
2008
Rattus norvegicus
Manually annotated by BRENDA team
Srivastava, A.; Pandey, S.N.; Choudhuri, G.; Mittal, B.
Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer
Mol. Genet. Metab.
94
83-89
2008
Homo sapiens
Manually annotated by BRENDA team
Gilardi, F.; Mitro, N.; Godio, C.; Scotti, E.; Caruso, D.; Crestani, M.; De Fabiani, E.
The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol
Pharmacol. Ther.
116
449-472
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wooton-Kee, C.; Cohen, D.; Vore, M.
Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat
Am. J. Physiol. Gastrointest. Liver Physiol.
294
G1009-G1016
2008
Rattus norvegicus
Manually annotated by BRENDA team
Burke, K.T.; Horn, P.S.; Tso, P.; Heubi, J.E.; Woollett, L.A.
Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G144-G151
2009
Mesocricetus auratus
Manually annotated by BRENDA team
Kojima, M.; Ashino, T.; Yoshida, T.; Iwakura, Y.; Sekimoto, M.; Degawa, M.
IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice
Biochem. Biophys. Res. Commun.
379
239-242
2009
Mus musculus
Manually annotated by BRENDA team
Li, T.; Ma, H.; Park, Y.J.; Lee, Y.K.; Strom, S.; Moore, D.D.; Chiang, J.Y.
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice
Biochim. Biophys. Acta
1791
991-996
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Han, S.; Chiang, J.Y.
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes
Drug Metab. Dispos.
37
469-478
2009
Homo sapiens
Manually annotated by BRENDA team
Song, K.H.; Li, T.; Owsley, E.; Strom, S.; Chiang, J.Y.
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
Hepatology
49
297-305
2009
Homo sapiens
Manually annotated by BRENDA team
Nass, N.; Schoeps, R.; Ulbrich-Hofmann, R.; Simm, A.; Hohndorf, L.; Schmelzer, C.; Raith, K.; Neubert, R.H.; Eder, K.
Screening for nutritive peptides that modify cholesterol 7alpha-hydroxylase expression
J. Agric. Food Chem.
56
4987-4994
2008
Homo sapiens
Manually annotated by BRENDA team
Xie, Y.; Blanc, V.; Kerr, T.A.; Kennedy, S.; Luo, J.; Newberry, E.P.; Davidson, N.O.
Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility
J. Biol. Chem.
284
16860-16871
2009
Mus musculus (Q64505), Mus musculus
Manually annotated by BRENDA team
Taniguchi, M.; Nagao, K.; Inoue, K.; Imaizumi, K.
Cholesterol lowering effect of sulfur-containing amino acids added to a soybean protein diet in rats
J. Nutr. Sci. Vitaminol.
54
448-453
2008
Rattus norvegicus
Manually annotated by BRENDA team
Pond, W.G.; Mersmann, H.J.; Su, D.; McGlone, J.J.; Wheeler, M.B.; Smith, E.O.
Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behavior
J. Nutr.
138
282-286
2008
Sus scrofa
Manually annotated by BRENDA team
Zhang, L.; Huang, X.; Meng, Z.; Dong, B.; Shiah, S.; Moore, D.D.; Huang, W.
Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration
Mol. Endocrinol.
23
137-145
2009
Mus musculus
Manually annotated by BRENDA team
Zhou, X.; Han, Y.; Liu, J.; Gao, L.; Zhao, J.
Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats
Pathol. Int.
59
729-734
2009
Rattus norvegicus
Manually annotated by BRENDA team
Kovar, J.; Lenicek, V.; Zimolova, M.; Vitek, L.; Jirsa, M.; Pitha, P.
Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects
Physiol. Res.
59
233-238
2010
Homo sapiens
Manually annotated by BRENDA team
De Castro-Oros, I.; Pampin, S.; Cofan, M.; Mozas, P.; Pinto, X.; Salas-Salvado, J.; Rodriguez-Rey, J.C.; Ros, E.; Civeira, F.; Pocovi, M.
Promoter variant -204A>C of the cholesterol 7alpha-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells
Clin. Nutr.
30
239-246
2010
Homo sapiens
Manually annotated by BRENDA team
Wooton-Kee, C.; Coy, D.; Athippozhy, A.; Zhao, T.; Jones, B.; Vore, M.
Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats
Hepatology
51
277-285
2010
Rattus norvegicus
Manually annotated by BRENDA team
Li, T.; Owsley, E.; Matozel, M.; Hsu, P.; Novak, C.M.; Chiang, J.Y.
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice
Hepatology
52
678-690
2010
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Song, K.H.; Li, T.; Owsley, E.; Chiang, J.Y.
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes
J. Lipid Res.
51
2223-2233
2010
Homo sapiens
Manually annotated by BRENDA team
Li, T.; Chanda, D.; Zhang, Y.; -SikChoi, H.; Chiang, J.
Glucose stimulates cholesterol 7 alpha-hydroxylase gene transcription in human hepatocytes
J. Lipid Res.
51
832-842
2010
Homo sapiens
Manually annotated by BRENDA team
Michelini, E.; Donati, M.; Aldini, R.; Cevenini, L.; Mezzanotte, L.; Nardini, P.; Foschi, C.; Zvi, I.B.; Cevenini, M.; Montagnani, M.; Marangoni, A.; Roda, A.; Cevenini, R.
Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription
Anal. Biochem.
430
92-96
2012
Homo sapiens
Manually annotated by BRENDA team
Li, T.; Matozel, M.; Boehme, S.; Kong, B.; Nilsson, L.M.; Guo, G.; Ellis, E.; Chiang, J.Y.
Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis
Hepatology
53
996-1006
2011
Rattus norvegicus (P18125)
Manually annotated by BRENDA team
Li, T.; Francl, J.M.; Boehme, S.; Chiang, J.Y.
Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice
Hepatology
58
1111-1121
2013
Homo sapiens, Rattus norvegicus (P18125)
Manually annotated by BRENDA team
Shinkyo, R.; Xu, L.; Tallman, K.A.; Cheng, Q.; Porter, N.A.; Guengerich, F.P.
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate
J. Biol. Chem.
286
33021-33028
2011
Homo sapiens
Manually annotated by BRENDA team
Kawase, A.; Yamada, A.; Gamou, Y.; Tahara, C.; Takeshita, F.; Murata, K.; Matsuda, H.; Samukawa, K.; Iwaki, M.
Increased effects of ginsenosides on the expression of cholesterol 7alpha-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism
J. Nat. Med.
67
545-553
2013
Rattus norvegicus
Manually annotated by BRENDA team
Frank, D.J.; Waddling, C.A.; La, M.; Ortiz de Montellano, P.R.
Cytochrome P450 125A4, the third cholesterol C-26 hydroxylase from Mycobacterium smegmatis
Biochemistry
54
6909-6916
2015
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Krishnamurthy, K.; Glaser, S.; Alpini, G.; Cardounel, A.J.; Liu, Z.; Ilangovan, G.
Heat shock factor-1 knockout enhances cholesterol 7alpha hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis
Cardiovasc. Res.
111
74-83
2016
Mus musculus (Q64505)
Manually annotated by BRENDA team
Chow, E.C.; Magomedova, L.; Quach, H.P.; Patel, R.; Durk, M.R.; Fan, J.; Maeng, H.J.; Irondi, K.; Anakk, S.; Moore, D.D.; Cummins, C.L.; Pang, K.S.
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol
Gastroenterology
146
1048-1059
2014
Homo sapiens (P22680), Homo sapiens, Mus musculus (Q64505), Mus musculus, Mus musculus C57BL/6 (Q64505)
Manually annotated by BRENDA team
Tempel, W.; Grabovec, I.; MacKenzie, F.; Dichenko, Y.V.; Usanov, S.A.; Gilep, A.A.; Park, H.W.; Strushkevich, N.
Structural characterization of human cholesterol 7alpha-hydroxylase
J. Lipid Res.
55
1925-1932
2014
Homo sapiens (P22680), Homo sapiens
Manually annotated by BRENDA team
Fu, Z.D.; Cui, J.Y.; Klaassen, C.D.
Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice
J. Lipid Res.
55
2576-2586
2014
Mus musculus (Q64505), Mus musculus C57BL/6 (Q64505)
Manually annotated by BRENDA team
Lammel Lindemann, J.A.; Angajala, A.; Engler, D.A.; Webb, P.; Ayers, S.D.
Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro
Mol. Cell. Endocrinol.
388
32-40
2014
Homo sapiens (P22680), Homo sapiens
Manually annotated by BRENDA team