1.14.14.19: steroid 17alpha-monooxygenase

This is an abbreviated version!
For detailed information about steroid 17alpha-monooxygenase, go to the full flat file.

Reaction

Synonyms

17 alpha-hydroxylase/C17,20-lyase, 17,20-lyase, 17-alpha-hydroxylase/C17-20 lyase, 17-hydroxylase/17,20-lyase, 17-hydroxylase/C17,20-lyase, 17alpha
hydroxylase, 17alpha-hydroxylase, 17alpha-hydroxylase 17,20 lyase, 17alpha-hydroxylase-17,20-lyase, 17alpha-hydroxylase-C17,20 lyase, 17alpha-hydroxylase-C17,20-lyase, 17alpha-hydroxylase/17,20 lyase, 17alpha-hydroxylase/17,20-lyase, 17alpha-hydroxylase/C(17,20)-lyase, 17alpha-OHase, 17OHD, CYP 17, CYP17, CYP17A1, CYPXVII, cytochrome P-450 (P45017alpha,lyase), cytochrome P-45017alpha, cytochrome P450 17, cytochrome P450 17A1, cytochrome P450 17A2, cytochrome P450 17alpha-hydroxylase, cytochrome P450 17alpha-hydroxylase-17,20-lyase, cytochrome P450 17alpha-hydroxylase/17,20 lyase, cytochrome P450 17alpha-hydroxylase/17,20-lyase, cytochrome p450 17alpha-hydroxylase/C(17,20)-lyase, cytochrome P450 17alpha-hydroxylase/C17,20-lyase, cytochrome P450 17alpha-hydroxylase/c17-20 lyase, cytochrome P45017alpha, cytochrome P450c17, cytochrome P450c17alpha, cytochromeP450 17alpha-hydroxylase/C17-20 lyase, EC 1.14.1.7, EC 1.14.99.9, EC 1.99.1.9, P450 17, P450 17A1, P450(17alpha), P450-17alpha, P450-C17, P45017alpha, P450c17, P450c17-I, Steroid 17-alpha-hydroxylase/17,20 lyase, steroid 17alpha-hydroxylase, steroidogenic cytochrome P450 17A1

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.19 steroid 17alpha-monooxygenase

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Results	in table
12	Activating Compound
840	AA Sequence
12	Application
1	CAS Registry Number
45	Cloned(Commentary)
42	Cofactor
4	Crystallization (Commentary)
698	Disease/ Diagnostics
5	Expression
91	General Information
246	IC50 Value
500	Inhibitors
10	kcat/KM [mM/s]
55	Ki Value [mM]
47	KM Value [mM]
48	Localization
11	Metals/Ions
8	Molecular Weight [Da]
140	Natural Substrates/ Products (Substrates)
294	Organism
8	Pathway
34	PDB ID
26	pH Optimum
5	Posttranslational Modification
52	Protein Variants
20	Purification (Commentary)
2	Reaction
10	Reaction Type
124	Reference
149	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
181	Substrates and Products (Substrate)
6	Subunits
156	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Range [°C]
18	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.14.14.19 - steroid 17alpha-monooxygenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2 progesterone + 2 AH2 + 2 O2

17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + 2 A + 2 H2O

Homo sapiens

-

-

680978

-

-

?

7-dehydropregnenolone + [reduced NADPH-hemoprotein reductase] + O2

7-dehydro-17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

726923

-

-

?

a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2

a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O

3 entries

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

23 entries

pregnenolone + ferrocytochrome b5 + O2

?

Homo sapiens

-

-

703551

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

6 entries

progesterone + 2 AH2 + 2 O2

androstenedione + acetate + 2 A + 2 H2O

Glandirana rugosa

A6P663

via 17alpha-hydroxyprogesterone

705396

-

-

?

progesterone + 2 NADPH + 2 H+ + 2 O2

androstenedione + acetate + 2 NADP+ + 2 H2O

Homo sapiens

-

reaction via 17alpha-hydroxyprogesterone

702581

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

6 entries

progesterone + ferrocytochrome b5 + O2

?

Homo sapiens

-

-

703551

-

-

?

progesterone + reduced acceptor + O2

17alpha-hydroxyprogesterone + acceptor + H2O

Homo sapiens

-

-

715857

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

2 entries

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

37 entries

additional information

?

-

23 entries

a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2

a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

733413, 734260

-

-

?

a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2

a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

734260

-

-

?

a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2

a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734283

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Bos taurus

-

-

390123, 390138, 686364

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Cavia porcellus

-

-

686364

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

-

390119

-

390119

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

-

390123, 390131, 390137, 390145, 680978, 685308, 686511, 688979, 691232, 704824, 716053

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

-

390121

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390121

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

-

390132

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390132

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

-

390133

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390133

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

-

390136

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390136

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

P05093

-

390120

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390120

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

-

390122

cytochrome b5 also as cofactor

390122

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Homo sapiens

-

17,20-lyase activity

691670, 692540

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Mesocricetus auratus

-

-

390127

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390127

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Oryctolagus cuniculus

-

-

390144

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Pelophylax lessonae

-

-

675512

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Rattus norvegicus

-

-

390119

-

390119

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Rattus norvegicus

-

-

390122

-

390122

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Rattus norvegicus

-

-

390137, 688979

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Rattus norvegicus

-

-

5129

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

5129

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Rattus norvegicus

-

-

390121

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390121

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Rattus norvegicus

-

-

390126

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390126

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Sus scrofa

-

-

390119

-

390119

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Sus scrofa

-

-

686364

-

-

?

pregnenolone + AH2 + O2

17alpha-hydroxypregnenolone + A + H2O

Sus scrofa

-

-

390140

product eliminates at C20,21 acetate to yield dehydroepiandrosterone

390140

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

735281

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

726886, 726923, 726997, 727947, 728213, 734260

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

734260

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734283, 734289, 735204

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Ovis aries

Q29497

-

727701

-

-

?

pregnenolone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

732996

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Bos taurus

-

-

686364

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Cavia porcellus

-

-

686364

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Homo sapiens

-

-

685308, 686511, 688979, 705509, 716053

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Pelophylax lessonae

-

-

675512

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Rattus norvegicus

-

-

688687, 688979, 714413

-

-

?

progesterone + AH2 + O2

17alpha-hydroxyprogesterone + A + H2O

Sus scrofa

-

-

686364

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

726997

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

728213

product ratio is 3:1

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Bos taurus

-

-

390123

product eliminates at C20,21 acetate to yield androstenedione

390123

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Bos taurus

-

-

390135

product eliminates at C20,21 acetate to yield androstenedione

390135

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Bos taurus

-

-

390138

product eliminates at C20,21 acetate to yield androstenedione

390138

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Cavia porcellus

-

-

287096

product eliminates at C20,21 acetate to yield androstenedione

287096

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Cavia porcellus

-

-

390124

product eliminates at C20,21 acetate to yield androstenedione

390124

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390137, 390145, 691232, 735281

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

726886, 726923, 734260

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

734260

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

P05093

-

734283, 734289, 735204

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390116

product eliminates at C20,21 acetate to yield androstenedione

390116

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390117

product eliminates at C20,21 acetate to yield androstenedione

390117

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390118

product eliminates at C20,21 acetate to yield androstenedione

390118

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390119

product eliminates at C20,21 acetate to yield androstenedione

390119

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390121

product eliminates at C20,21 acetate to yield androstenedione

390121

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390123

product eliminates at C20,21 acetate to yield androstenedione

390123

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390124

product eliminates at C20,21 acetate to yield androstenedione

390124

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390125

product eliminates at C20,21 acetate to yield androstenedione

390125

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390128

product eliminates at C20,21 acetate to yield androstenedione

390128

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390131

product eliminates at C20,21 acetate to yield androstenedione

390131

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

-

390132

product eliminates at C20,21 acetate to yield androstenedione

390132

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Homo sapiens

-

17,20-lyase activity

691670, 692540

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Mesocricetus auratus

-

-

390127

product eliminates at C20,21 acetate to yield androstenedione

390127

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Oryctolagus cuniculus

-

-

390144

-

390144

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Ovis aries

Q29497

-

727701

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

390137, 705395, 732996

-

-

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

5129

product eliminates at C20,21 acetate to yield androstenedione

5129

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

287096

product eliminates at C20,21 acetate to yield androstenedione

287096

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

390116

product eliminates at C20,21 acetate to yield androstenedione

390116

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

390118

product eliminates at C20,21 acetate to yield androstenedione

390118

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

390119

product eliminates at C20,21 acetate to yield androstenedione

390119

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

390121

product eliminates at C20,21 acetate to yield androstenedione

390121

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Rattus norvegicus

-

-

390130

product eliminates at C20,21 acetate to yield androstenedione

390130

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Sus scrofa

-

-

390119

product eliminates at C20,21 acetate to yield androstenedione

390119

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Sus scrofa

-

-

390134

product eliminates at C20,21 acetate to yield androstenedione

390134

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Sus scrofa

-

-

390140

product eliminates at C20,21 acetate to yield androstenedione

390140

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Sus scrofa

-

-

390141

product eliminates at C20,21 acetate to yield androstenedione

390141

?

progesterone + [reduced NADPH-hemoprotein reductase] + O2

17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O

Sus scrofa

-

-

390142

product eliminates at C20,21 acetate to yield androstenedione

390142

?

additional information

?

-

Bos taurus

-

the enzyme catalyzes the key branch point in the metabolic conversion of cholesterol either to androgens and estrogens, or to glucocorticoids

686364

-

-

?

additional information

?

-

Cavia porcellus

-

the enzyme catalyzes the key branch point in the metabolic conversion of cholesterol either to androgens and estrogens, or to glucocorticoids

686364

-

-

?

additional information

?

-

Homo sapiens

-

it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol

390121

-

-

?

additional information

?

-

Homo sapiens

-

it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol

390122

-

-

?

additional information

?

-

Homo sapiens

P05093

it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol

390120

-

-

?

additional information

?

-

Homo sapiens

-

it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol

390120

-

-

?

additional information

?

-

Homo sapiens

-

catalyzes the last step of androgen biosynthesis in both testes and adrenals

390115

-

-

?

additional information

?

-

Homo sapiens

-

CYP17 is a key enzyme in steroid hormone biosynthesis

685308

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is is essential for the maintenance of normal male and female sexual characteristics, as well as the stress response and mineral balance in all mammals

680978

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is required for androgen production, genetic regulation, overview

687964

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additional information

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Homo sapiens

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CYP17 is the cytochrome b5 modulated key enzyme for the biosynthesis of androgens, catalyzing the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent cleavage of the C 20,21-acetyl group to yield the corresponding androgens dehydroepiandrosterone and androstendione

703551

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additional information

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Homo sapiens

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cytochrome P-450 17alpha-hydroxylase-17,20-lyase, CYP17, is a multifunctional enzyme. CYP17 catalyzes at the same active site not only the hydroxylation process but also an acyl-carbon bond cleavage reaction which involves the nucleophilic attack of the ferric-peroxyanion, Fe(III)-O-O-, on the acyl-carbon to furnish a tetrahedral intermediate which fragments, leading to acyl-carbon cleavage

716053

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additional information

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Homo sapiens

P05093

CYP17 is unique due to its ability to catalyze two independent reactions in the same active center, the 17alpha-hydroxylase and 17,20-lyase reactions

726923

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additional information

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Homo sapiens

P05093

the multifunctional enzyme catalyzes the 17alpha-hydroxylation of DELTA4- and DELTA5-steroids progesterone and pregnenolone to form the corresponding 17alpha-hydroxy products through its hydroxylase activity, and a subsequent 17,20-carbon-carbon scission of pregnene-side chain produce the androgens androstenedione and dehydroepiandrosterone

726886

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additional information

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Homo sapiens

P05093

a minor conformation may yield the minor 16alpha-hydroxyprogesterone metabolite from progesterone

734283

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additional information

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Homo sapiens

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a minor conformation may yield the minor 16alpha-hydroxyprogesterone metabolite from progesterone

734283

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additional information

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Homo sapiens

P05093

the enzyme also shows 17,20-lyase activity which is stimulated by cytochrome b5

734289

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additional information

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Ovis aries

Q29497

the bifunctional enzyme catalyzes two types of reactions, namely, a 17alpha-hydroxylation reaction and a 17,20-lyase reaction

727701

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additional information

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Rattus norvegicus

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it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol

390121

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additional information

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Rattus norvegicus

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it catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities in the biosynthesis of androgens, estrogens and cortisol

390122

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additional information

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Rattus norvegicus

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CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin

705395

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additional information

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Rattus norvegicus

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the enzyme is involved in androstenedione production

706689

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additional information

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Sus scrofa

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the enzyme catalyzes the key branch point in the metabolic conversion of cholesterol either to androgens and estrogens, or to glucocorticoids

686364

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