1.14.14.18: heme oxygenase (biliverdin-producing)

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For detailed information about heme oxygenase (biliverdin-producing), go to the full flat file.

Word Map on EC 1.14.14.18

1.14.14.18

monoxide

cytoprotective

endothelial

necrosis

dismutase

protoporphyrin

erythroid

2-related

tnf

bilirubin

artery

malondialdehyde

lipopolysaccharide

catalase

hemin

neuroprotective

ischemia

gsh

lps

sod

anti-oxidant

mapks

sirna

caspase-3

quinone

pulmonary

reperfusion

lps-induced

hypoxia

cyclooxygenase-2

cox-2

ferritin

erk

nf-e2-related

anti-apoptotic

cobalt

myeloperoxidase

ischemia-reperfusion

nrf2-mediated

pro-oxidant

kelch-like

nadph:quinone

factor-2

lps-stimulated

2-like

erythroid-derived

oxygenases

delta-aminolevulinic

sulforaphane

hyperbilirubinemia

medicine

drug development

analysis

Reaction

+ 3 [reduced NADPH-hemoprotein reductase] + 3 O2 =

+ 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O

Synonyms

biliverdin-producing heme oxygenase, ChuS, ChuZ, EC 1.14.99.3, haem oxygenase, heme oxygenase, heme oxygenase 1, heme oxygenase 2, heme oxygenase-1, heme oxygenase-2, HemO, Hmox1, Hmox1a, Hmox1b, Hmox2, Hmox2a, Hmox2b, HmuO, Hmx1, HO, HO-1, HO-2, Ho1, Ho2, Ho3, HO4, HSP32, HugZ, HY1, inducible heme oxygenase-1, More, MsHO1, ORP33 proteins, oxygenase, heme (decyclizing), pbsA1, PigA, proteins, specific or class, ORP33 (oxygen-regulated protein 33,000-mol.-wt.), Syn HO-1, Syn HO-2

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.18 heme oxygenase (biliverdin-producing)

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Results	in table
68	Activating Compound
4904	AA Sequence
17	Application
1	CAS Registry Number
54	Cloned(Commentary)
31	Cofactor
38	Crystallization (Commentary)
8860	Disease/ Diagnostics
31	Expression
77	General Information
2	General Stability
214	IC50 Value
432	Inhibitors
5	Ki Value [mM]
37	KM Value [mM]
65	Localization
20	Metals/Ions
36	Molecular Weight [Da]
127	Natural Substrates/ Products (Substrates)
587	Organism
6	Pathway
27	PDB ID
32	pH Optimum
2	pH Range
2	pH Stability
1	Posttranslational Modification
111	Protein Variants
37	Purification (Commentary)
18	Reaction
3	Reaction Type
240	Reference
317	Source Tissue
43	Specific Activity [micromol/min/mg]
6	Storage Stability
304	Substrates and Products (Substrate)
37	Subunits
317	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
2	Temperature Range [°C]
14	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.18 - heme oxygenase (biliverdin-producing)

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protoheme,NADPH-hemoprotein reductase:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)

This mammalian enzyme participates in the degradation of heme. The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules [4]. The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. The enzyme requires NAD(P)H and EC 1.6.2.4, NADPH---hemoprotein reductase. cf. EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin).