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1.14.14.17: squalene monooxygenase

This is an abbreviated version!
For detailed information about squalene monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.17

Reaction

squalene
+
[reduced NADPH-hemoprotein reductase]
+
O2
=
(3S)-2,3-epoxy-2,3-dihydrosqualene
+
[oxidized NADPH-hemoprotein reductase]
+
H2O

Synonyms

CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, EC 1.14.13.132, EC 1.14.99.7, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, PgSQE1, PgSQE2, SE, SE1, SE3, SQE, SQE-I, SQE-II, sqe1, SQE3, SQLE, squalen expoxidase, squalene 2,3-epoxidase, squalene 2,3-oxidocyclase, squalene epoxidase, squalene epoxidase 1, squalene epoxidase 3, squalene hydroxylase, squalene mono-oxygenase, squalene oxydocyclase, squalene-2,3-epoxidase, squalene-2,3-epoxide cyclase, TkSQE1, TkSQE2, TkSQE3, TkSQE4

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.17 squalene monooxygenase

Substrates Products

Substrates Products on EC 1.14.14.17 - squalene monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene + 1-carba-1-deaza-FAD + H2O
squalene + 1-carba-1-deaza-FADH2 + O2
show the reaction diagram
-
-
-
-
r
(3S)-2,3-epoxy-2,3-dihydrosqualene + FAD + H2O
squalene + FADH2 + O2
show the reaction diagram
(3S)-squalene-2,3-epoxide + AH2 + O2
(3S,22S)-2,3-22,23-dioxidosqualene + A + H2O
show the reaction diagram
-
the wild-type enzyme also catalyzes conversion of (3S)2,3-oxidosqualene to (3S,22S)-2,3-22,23-dioxidosqualene
-
-
?
1,1-bisnorsqualene + NADPH + O2
1,1-bisnor-squalene-2,3-epoxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
1-methylsqualene + NADPH + O2
1-methyl-squalene-2,3-epoxide + NADP+ + H2O
show the reaction diagram
-
-
-
?
1-norsqualene + NADPH + O2
1-norsqualene-2,3-epoxide + NADP+ + H2O
show the reaction diagram
-
-
-
?
10,11,14,15-tetrahydrosqualene + NADPH + O2
10,11,14,15-tetrahydro-squalene-2,3-epoxide + NADP+ + H2O
show the reaction diagram
-
-
-
?
10,11-dihydrosqualene + NADPH + O2
10,11-dihydro-squalene-2,3-epoxide + NADP+ + H2O
show the reaction diagram
-
-
-
?
2,3-dihydrosqualene + NADPH + O2
?
show the reaction diagram
-
-
-
-
?
2,3-oxidosqualene + NADPH + O2
2,3,22,23-dioxidosqualene + NADP+ + H2O
show the reaction diagram
-
N-terminal truncated recombinant enzyme
-
?
6,7,18,19-tetrahydrosqualene + NADPH + O2
6,7,18,19-tetrahydro-(S)-squalene-2,3-epoxide
show the reaction diagram
-
-
-
?
squalene + AH2 + O2
(3S)-squalene-2,3-epoxide + A + H2O
show the reaction diagram
squalene + AH2 + O2
(S)-squalene-2,3-epoxide + A + H2O
show the reaction diagram
squalene + electron donor + O2
(S)-squalene-2,3-epoxide + oxidized electron donor + H2O
show the reaction diagram
squalene + NAD(P)H + O2
(S)-squalene-2,3-epoxide + NADP+ + H2O
show the reaction diagram
squalene + O2 + AH2
2,3 oxidosqualene + A + H2O
show the reaction diagram
squalene + reduced acceptor + O2
(S)-squalene-2,3-epoxide + acceptor + H2O
show the reaction diagram
squalene + reduced cytochrome P450 + H+ + O2
(3S)-squalene-2,3-epoxide + cytochrome P450 + H2O
show the reaction diagram
absolutely stereo- and regiospecific reaction, co-reaction with NADPH-cytochrome P450 reductase
-
-
?
squalene + reduced cytochrome P450 + O2
(S)-squalene-2,3-epoxide + cytochrome P450 + H2O
show the reaction diagram
first step in the cyclic chloesterol biosynthesis
-
-
?
squalene + reduced NADPH-cytochrome P450 reductase + O2
(3S)-2,3-epoxy-2,3-dihydrosqualene + oxidized NADPH-cytochrome P450 reductase + H2O
show the reaction diagram
-
-
-
-
r
squalene + [reduced NADPH-hemoprotein reductase] + O2
(3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
additional information
?
-