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1.14.14.17: squalene monooxygenase

This is an abbreviated version!
For detailed information about squalene monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.17

Reaction

squalene
+
[reduced NADPH-hemoprotein reductase]
 +
O2
=
(3S)-2,3-epoxy-2,3-dihydrosqualene
 +
[oxidized NADPH-hemoprotein reductase]
 +
H2O

Synonyms

CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, EC 1.14.13.132, EC 1.14.99.7, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, PgSQE1, PgSQE2, SE, SE1, SE3, SQE, SQE-I, SQE-II, sqe1, SQE3, SQLE, squalen expoxidase, squalene 2,3-epoxidase, squalene 2,3-oxidocyclase, squalene epoxidase, squalene epoxidase 1, squalene epoxidase 3, squalene hydroxylase, squalene mono-oxygenase, squalene oxydocyclase, squalene-2,3-epoxidase, squalene-2,3-epoxide cyclase, TkSQE1, TkSQE2, TkSQE3, TkSQE4

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.14.17 squalene monooxygenase

Expression

Expression on EC 1.14.14.17 - squalene monooxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enhanced expression following stimulation with ethephon and methyl jasmonate
enzyme expression is upregulated in hepatocellular carcinoma tissues
-
expression analysis reveals the coregulation of squalene synthase TkSQS1 and squalene epoxidase TkSQE1, along with a downstream gene in the triterpene biosynthesis pathway encoding the oxidosqualene cyclase TkOSC1
expression is weakly induced by methyl jasmonate
in presence of methyl jasmonate, expression of SE3 is increased at 3h, and decreases at 6h, then increases reaching a high expression level at 24h
methyl jasmonate treatment suppresses expression of PgSQE2
B7TWW5, Q75W20
methyl jasmonate treatment upregulates SE1 expression in both the young and mature leaves. Maximum upregulation in response to 50 microM methyljasmonate but not to 100 microM
-
no induction in presence of abscisic acid
overexpression of the squalene synthase 1 gene in the sense orientation increases the mRNA accumulation of downstream genes such as squalene epoxidase. Methyl jasmonate treatment of wild type roots enhances the expression of the enzyme
-
squalene treatment coordinately upregulates the expression of PgSQE1, and methyl jasmonate treatment enhances the accumulation of PgSQE1 mRNA in roots. Silencing of PgSQE1 in RNAi roots strongly upregulates PgSQE2 and PNX, cycloartenol synthase, and results in enhanced phytosterol accumulation
B7TWW5, Q75W20
squalene treatment coordinately upregulates the expression of PgSQE2. Silencing of PgSQE1 in RNAi roots strongly upregulates PgSQE2 and PNX, cycloartenol synthase, and results in enhanced phytosterol accumulation
B7TWW5, Q75W20
the relative expression level of SQE-I is almost constant throughout the culture period
the relative expression level of SQE-II increases 3.5fold from the early stage to the middle phase of a culture period of 42 days