1.14.14.17: squalene monooxygenase

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For detailed information about squalene monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.17

1.14.14.17

cholesterol

sterol

terbinafine

ergosterol

trichophyton

mevalonate

lanosterol

allylamine

2,3-oxidosqualene

hmg-coa

itraconazole

mentagrophytes

rubrum

oxidosqualene

terbinafine-resistant

tellurium

tinea

naftifine

interdigitale

antimycotic

bloch

griseofulvin

dammarenediol

dermatophytoses

cycloartenol

beta-amyrin

medicine

corporis

drug development

nutrition

biotechnology

pharmacology

cholesterogenic

synthesis

Reaction

Synonyms

CYP17, cytochrome P450 17alpha hydroxylase/17,20 lyase, EC 1.14.13.132, EC 1.14.99.7, Erg1, Erg1 protein, Erg1p, hydroxylase, squalene, oxygenase, squalene mono-, PgSQE1, PgSQE2, SE, SE1, SE3, SQE, SQE-I, SQE-II, sqe1, SQE3, SQLE, squalen expoxidase, squalene 2,3-epoxidase, squalene 2,3-oxidocyclase, squalene epoxidase, squalene epoxidase 1, squalene epoxidase 3, squalene hydroxylase, squalene mono-oxygenase, squalene oxydocyclase, squalene-2,3-epoxidase, squalene-2,3-epoxide cyclase, TkSQE1, TkSQE2, TkSQE3, TkSQE4

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.17 squalene monooxygenase

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Results	in table
15	Activating Compound
4611	AA Sequence
9	Application
1	CAS Registry Number
32	Cloned(Commentary)
41	Cofactor
2	Crystallization (Commentary)
167	Disease/ Diagnostics
14	Expression
22	General Information
2	General Stability
4	IC50 Value
154	Inhibitors
15	Ki Value [mM]
21	KM Value [mM]
27	Localization
1	Metals/Ions
16	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
154	Organism
7	Pathway
6	PDB ID
8	pH Optimum
7	pI Value
71	Protein Variants
15	Purification (Commentary)
5	Reaction
4	Reaction Type
81	Reference
2	Renatured (Commentary)
69	Source Tissue
8	Specific Activity [micromol/min/mg]
5	Storage Stability
71	Substrates and Products (Substrate)
18	Subunits
83	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
6	Turnover Number [1/s]

Application

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Application on EC 1.14.14.17 - squalene monooxygenase

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biotechnology

2 entries

drug development

Canis lupus familiaris

possible enzyme to inhibit for treatment of hypercholesterolemia, but strong side effects (e.g. dermatitis-like toxicity)

medicine

nutrition

expression of myogenic marker genes (Myog, Myod, and Myh4) and adipogenic marker genes (Pparg, Cebpa, and Adipoq) is substantially downregulated in cells transfected with squalene epoxidase siRNA. mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, are significantly downregulated by squalene epoxidase knockdown

746469

pharmacology

Saccharomyces cerevisiae

squalene epoxidase is an attractive potential target for drugs used to inhibit the growth of pathogenic fungi or to lower cholesterol level in humans

715725

synthesis

Ganoderma lucidum

A0A1Y0JYI5

simultaneous overexpression of squalene epoxidase and 3-hydroxy-3-methylglutaryl coenzyme A enhances individual ganoderic acid production. The overexpressing strain produces maximum ganoderic acid-T, ganoderic acid-S, ganoderic acid-Mk, and ganoderic acid-Me contents of 90.4, 35.9, 6.2, and 61.8 microg/100 mg dry weight, respectively

745145