1.14.14.16: steroid 21-monooxygenase

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For detailed information about steroid 21-monooxygenase, go to the full flat file.

Word Map on EC 1.14.14.16

1.14.14.16

adrenal

hyperplasia

cortisol

virilize

androgen

17-hydroxyprogesterone

glucocorticoid

children

acth

steroidogenic

testosterone

adrenocortical

salt-wasting

aldosterone

hirsutism

nonclassical

prenatal

girl

androstenedione

genitalia

steroidogenesis

mineralocorticoid

hyperandrogenism

hydrocortisone

addison

puberty

11-deoxycortisol

dehydroepiandrosterone

beta-hydroxysteroid

11beta-hydroxylase

adrenarche

p450scc

c4a

endocrinologist

acth-stimulated

pseudohermaphroditism

debrisoquine

biotechnology

1'-hydroxylation

hsd3b2

incidentalomas

cyp11b1

masculinization

bufuralol

medicine

deoxycorticosterone

adrenocorticotropic

11-deoxycorticosterone

17alpha-hydroxylase

dextromethorphan

fludrocortisone

hyperandrogenemia

Reaction

Synonyms

17alpha-hydroxyprogesterone 21-hydrolase, 21-hydroxylase, 21-hydroxylase cytochrome P-450, 21OH, C3B21RA protein, CYP21, CYP21A2, CYP2D, Cytochrome P-450 specific for steroid C-21 hydroxylation, cytochrome P-450-linked mixed function oxidase system, cytochrome P-450C-21, cytochrome p450 21A2, cytochrome P450 steroid 21-hydroxylase, cytochrome P450c21, EC 1.14.1.8, EC 1.14.99.10, EC 1.99.1.11, P-450(C21), P450 oxidoreductase-21-hydroxylase, P450-C21, P450-C21B, P450c21, Progesterone 21-hydroxylase, Steroid 21-hydroxylase, steroid 21-hydroxylase system, steroid 21-hydroxylation system, steroid cytochrome P450 21-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.16 steroid 21-monooxygenase

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Results	in table
15	Activating Compound
46	AA Sequence
5	Application
1	CAS Registry Number
19	Cloned(Commentary)
20	Cofactor
4	Crystallization (Commentary)
11190	Disease/ Diagnostics
15	General Information
28	Inhibitors
36	kcat/KM [mM/s]
75	KM Value [mM]
13	Localization
4	Metals/Ions
12	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
52	Organism
6	Pathway
8	pH Optimum
2	pH Range
1	Posttranslational Modification
135	Protein Variants
12	Purification (Commentary)
1	Reaction
4	Reaction Type
51	Reference
18	Source Tissue
13	Specific Activity [micromol/min/mg]
3	Storage Stability
85	Substrates and Products (Substrate)
7	Subunits
72	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
39	Turnover Number [1/s]

Purification

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Purification on EC 1.14.14.16 - steroid 21-monooxygenase

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3 entries

enzyme system consisting of cytochrome P-450S21 and NADPH-cytochrome P-450 reductase

Bos taurus

285440

HisTrap HP column chromatography (using Ni2+ ions immobilized onto a metal-chelating column)

Homo sapiens

P08686

698536

Ni-NTA agarose column chromatography, and SP Fast-Flow Sepharose column chromatography

Homo sapiens

P08686

734302

recombinant His-tagged enzyme from Escherichia coli strain JM109 by nickel affinity chromatography

Homo sapiens

726923

recombinant His-tagged wild-type enzyme and mutants from Escherichia coli by nickel affinity and anion exchange chromatography, followed by gel filtration

Bos taurus

P00191

727898

recombinant wild-type and mutant enzymes from yeast microsomes

Homo sapiens

726997