1.14.14.14: aromatase

This is an abbreviated version!
For detailed information about aromatase, go to the full flat file.

Word Map on EC 1.14.14.14

1.14.14.14

estrogen

women

androgen

steroid

postmenopausal

ovarian

tamoxifen

ovary

progesterone

letrozole

granulosa

follicle

gonad

anastrozole

receptor-positive

fsh

steroidogenic

exemestane

androstenedione

gonadotropin

steroidogenesis

endometrial

lutein

follicular

testicular

antiestrogens

fulvestrant

er-positive

nonsteroidal

endometriosis

neoadjuvant

preoptic

third-generation

hormone-dependent

follicle-stimulating

gnrh

estrogen-dependent

oestradiol

dihydrotestosterone

premenopausal

mastectomy

arthralgia

17beta-hydroxysteroid

everolimus

5alpha-reductase

cyp17a1

raloxifene

medicine

virilization

progestin

her2-negative

Reaction

+ 2 H2O +

Synonyms

AROM, Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

1.14.14.14 aromatase

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Results	in table
33	AA Sequence
7	Application
3	Cloned(Commentary)
3	Cofactor
5	Crystallization (Commentary)
25448	Disease/ Diagnostics
9	Expression
6	General Information
41	IC50 Value
77	Inhibitors
6	Ki Value [mM]
5	KM Value [mM]
8	Localization
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
50	Organism
4	Pathway
5	PDB ID
1	pH Range
1	Posttranslational Modification
6	Protein Variants
3	Purification (Commentary)
8	Reaction
50	Reference
53	Source Tissue
1	Specific Activity [micromol/min/mg]
25	Substrates and Products (Substrate)
4	Subunits
22	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.14.14 - aromatase

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testosterone monooxygenase (17beta-estradiol-forming)

A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.