1.14.14.14: aromatase
This is an abbreviated version!
For detailed information about aromatase, go to the full flat file.
Word Map on EC 1.14.14.14
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1.14.14.14
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estrogen
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women
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androgen
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steroid
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postmenopausal
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ovarian
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tamoxifen
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ovary
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progesterone
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letrozole
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granulosa
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follicle
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gonad
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anastrozole
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receptor-positive
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fsh
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steroidogenic
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exemestane
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androstenedione
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gonadotropin
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steroidogenesis
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endometrial
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lutein
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follicular
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testicular
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antiestrogens
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fulvestrant
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er-positive
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nonsteroidal
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endometriosis
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neoadjuvant
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preoptic
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third-generation
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hormone-dependent
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follicle-stimulating
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gnrh
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estrogen-dependent
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oestradiol
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dihydrotestosterone
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premenopausal
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mastectomy
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arthralgia
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17beta-hydroxysteroid
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everolimus
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5alpha-reductase
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cyp17a1
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raloxifene
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medicine
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virilization
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progestin
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her2-negative
- 1.14.14.14
- estrogen
- women
- androgen
- steroid
-
postmenopausal
- ovarian
- tamoxifen
- ovary
- progesterone
- letrozole
-
granulosa
- follicle
- gonad
- anastrozole
-
receptor-positive
- fsh
-
steroidogenic
- exemestane
- androstenedione
- gonadotropin
- steroidogenesis
- endometrial
- lutein
- follicular
- testicular
-
antiestrogens
-
fulvestrant
-
er-positive
-
nonsteroidal
- endometriosis
-
neoadjuvant
-
preoptic
-
third-generation
-
hormone-dependent
-
follicle-stimulating
- gnrh
-
estrogen-dependent
- oestradiol
- dihydrotestosterone
-
premenopausal
-
mastectomy
- arthralgia
-
17beta-hydroxysteroid
-
everolimus
-
5alpha-reductase
- cyp17a1
- raloxifene
- medicine
-
virilization
- progestin
-
her2-negative
Reaction
Synonyms
AROM, Cyp19a, CYP19A1, Cyp19a1a, Cyp19a1b, Cyp19A3, cytochrome P450 aromatase, P450arom
ECTree
1.14.14.14 aromataseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.14.14.14 - aromatase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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maternal ovaries and adrenals maintain high aromatase activity throughout gestation
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cell line expresses aromatase mRNA and shows a cytoplasmic pattern of aromatase immunoreactivity. In addition, the cell line expresses estrogen receptor alpha
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aromatase activity in the developing brains and gonads of embryos is comparable with measurements in oviparous reptiles. Aromatase activity in the embryonic gonads is low at embryonic stage 29-34, but increases significantly at mid-development and then remains high in late stage embryos
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cell line expresses aromatase mRNA and shows a cytoplasmic pattern of aromatase immunoreactivity. In addition, the cell line expresses estrogen receptor alpha
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cell line expresses aromatase mRNA and shows a cytoplasmic pattern of aromatase immunoreactivity. In addition, the cell line expresses estrogen receptor alpha
additional information
Cyp19a1b is solely detected at putative radial glial cells of the forebrain, close to the brain ventricles
high transcript abundance in the female brain, followed by gonads, liver, gill, kidney and muscle
high transcript abundance in the ovary and female brain, followed by the testis and male brain, and female liver and muscle
higher aromatase expression in female compared with male cerebral vessels
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male brain aromatase activity is signficantly increased by treatments with estradiol or ethynylestradiol while female brain aromatase activity is unaffected
high transcript abundance in the female brain, followed by gonads, liver, gill, kidney and muscle
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in the female, activity is detecable throughout the year
AROM and NOS proteins are coexpressed with NADPH oxidase in the preoptic-anterior hypothalamus
high transcript abundance in the female brain, followed by gonads, liver, gill, kidney and muscle
high transcript abundance in the ovary and female brain, followed by the testis and male brain, and female liver and muscle
high transcript abundance in the female brain, followed by gonads, liver, gill, kidney and muscle
high transcript abundance in the ovary and female brain, followed by the testis and male brain, and female liver and muscle
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maternal ovaries and adrenals maintain high aromatase activity throughout gestation
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activity is found only during vitellogenesis. At the completion of vitellogenesis, ovarian aromatase activity declines sharply resulting in elevation of plasma testosterone levels
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increases in aromatase activities of the ovary and testis precede the onset of the ovarian and testicular development. Aromatase activities reach the highest level at the growing stage in February and the mature stage in March, and show a striking decrease at the spawning stage in April. Contents of ovarian and testicular estradiol-17beta change similarly to the profile of aromatase activities in the ovary and testis, although estrone shows no change
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ovarian aromatase activity is significantly decreased by treatments with estradiol or ethynylestradiol
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during the early phases of embryonic development, placental aromatase activity is comparable to that in maternal ovaries, but declines significantly at progressive stages of gestation
high transcript abundance in the ovary and female brain, followed by the testis and male brain, and female liver and muscle
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immunoreactivities against aromatase and estradiol-17beta are detected in the cells along the inside of the acinar wall of the testis
additional information
brain aromatase expression does not differ between types of males, but pituitary Cyp19a1b expression levels positively correlate with the index of agonistic behavior
additional information
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brain aromatase expression does not differ between types of males, but pituitary Cyp19a1b expression levels positively correlate with the index of agonistic behavior
additional information
Cyp19a1b expression is higher in females than males
additional information
Cyp19a1b expression is higher in females than males
additional information
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Cyp19a1b expression is higher in females than males
