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1.14.13.84: 4-hydroxyacetophenone monooxygenase

This is an abbreviated version!
For detailed information about 4-hydroxyacetophenone monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.84

Reaction

(4-hydroxyphenyl)ethan-1-one
+
NADPH
+
H+
+
O2
=
4-hydroxyphenyl acetate
+
NADP+
+
H2O

Synonyms

4-hydroxyacetophenone monooxygenase, arylketone monooxygenase, Baeyer-Villiger monooxygenase, hAPA, HAPMO, More, oxygenase, 4-hydroxyacetophenone mono-

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.84 4-hydroxyacetophenone monooxygenase

Inhibitors

Inhibitors on EC 1.14.13.84 - 4-hydroxyacetophenone monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-Aminopyridine adenine dinucleotide phosphate
-
cofactor analogue, tight binding to the wild-type enzyme and mutant R440A
acetyl-NADP+
-
0.5 mM, 35% inhibition
amino-NADP+
-
very effective inhibitor, 0.005 mM, 80% inhibition
hexane
-
enzyme activity is markedly reduced at concentrations of hexane below 5% and over 30%
additional information
-
not inhibited by NADP+
-