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1.14.13.50: pentachlorophenol monooxygenase

This is an abbreviated version!
For detailed information about pentachlorophenol monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.50

Reaction

2,3,5,6-Tetrachlorophenol
+
NADPH
+
H+
+
O2
=
2,3,5,6-tetrachlorohydroquinone
+
NADP+
+
H2O

Synonyms

CpsB, dechlorinase, pentachlorophenol, GM610_18120, oxygenase, pentachlorophenol 4-mono-, PCB hydroxylase, PCP 4-monooxygenase, PCP hydroxylase, PCP-4-monooxygenase, PCP-monooxygenase, PCP4MO, PcpB, PcpD, pentachlorophenol 4-mono-oxygenase, pentachlorophenol 4-monooxygenase, pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol hydroxylase, pentachlorophenol monooxygenase, pentachlorophenol-4-monooxygenase, Phe4MO, tetrachlorobenzoquinone reductase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.50 pentachlorophenol monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.50 - pentachlorophenol monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)
A flavoprotein (FAD). The enzyme displaces a diverse range of substituents from the 4-position of polyhalogenated phenols but requires that a halogen substituent be present at the 2-position [2]. If C-4 carries a halogen substituent, reaction 1 is catalysed; if C-4 is unsubstituted, reaction 2 is catalysed.